Results 1 to 10 of about 36,080 (146)

Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation. [PDF]

PLoS Pathogens, 2016
Identifying host immune determinants governing HIV transcription, latency and infectivity in vivo is critical to developing an HIV cure. Based on our recent finding that the host factor p21 regulates HIV transcription during antiretroviral therapy (ART),
Mohamed Abdel-Mohsen, Leonard Chavez, Ravi Tandon, Glen M Chew, Xutao Deng, Ali Danesh, Sheila Keating, Marion Lanteri, Michael L Samuels, Rebecca Hoh, Jonah B Sacha, Philip J Norris, Toshiro Niki, Cecilia M Shikuma, Mitsuomi Hirashima, Steven G Deeks, Lishomwa C Ndhlovu, Satish K Pillai   +17 more
doaj   +5 more sources

Peripheral blood TIM-3 positive NK and CD8+ T cells throughout pregnancy: TIM-3/galectin-9 interaction and its possible role during pregnancy. [PDF]

PLoS ONE, 2014
The T-cell immunoglobulin and mucin domain (TIM) family is a relatively newly described group of molecules with a conserved structure and important immunological functions. Identification of Galectin-9 as a ligand for TIM-3 has established the Galectin-9/
Matyas Meggyes, Eva Miko, Beata Polgar, Barbara Bogar, Balint Farkas, Zsolt Illes, Laszlo Szereday   +6 more
doaj   +3 more sources

Autophagy-independent role of ATG9A vesicles as carriers for galectin-9 secretion [PDF]

Nature Communications
Galectins play vital roles in cellular processes such as adhesion, communication, and survival, yet the mechanisms underlying their unconventional secretion remain poorly understood.
Wenting Zhang, Cuicui Ji, Xianghua Li, Tianlong He, Wei Jiang, Yukun Liu, Meiling Wu, Yunpeng Zhao, Xuechai Chen, Xiaoli Wang, Jian Li, Haolin Zhang, Juan Wang   +12 more
doaj   +2 more sources

Galectin-9 binds IgM-BCR to regulate B cell signaling [PDF]

Nature Communications, 2018
The galectin family of secreted lectins are important regulators of immune cell function; however, their role in B cell responses is poorly understood. Here, the authors identify IgM-BCR as a ligand for galectin-9.
Anh Cao, Nouf Alluqmani, Fatima Hifza Mohammed Buhari, Laabiah Wasim, Logan K. Smith, Andrew T. Quaile, Michael Shannon, Zaki Hakim, Hossai Furmli, Dylan M. Owen, Alexei Savchenko, Bebhinn Treanor   +11 more
doaj   +5 more sources

Tim-3/galectin-9 regulates Th1/Th2 cell balance in lipopolysaccharide-induced human lymphocytes [PDF]

Jichu yixue yu linchuang, 2023
Objective To investigate the mechanism of Tim-3/galectin-9 in T helper type 1/2 (Th1/Th2) cell imbalance in lipopolysaccharide(LPS)-induced human lymphocytes.
SUN Xiaoli, ZHANG Jinjin, SONG Fengying, HUANG Yongli, CHEN Lili, XING Yanchao
doaj   +1 more source

The role of salivary galectin-3 and galectin-9 levels in plaque-induced gingivitis and periodontitis

Heliyon, 2023
Background: This study aimed to compare the salivary galectin-3 and galectin-9 levels in periodontitis, gingivitis, and periodontally healthy patients. Methods: This study included 75 non-smokers who were systemically healthy.
Zerrin Barut, Ahmet Mert Nalbantoğlu, Hilal Korkmaz, Zeynep Demir, Mükerrem Hatipoğlu, Aysun Özkan, Şule Bulut   +6 more
doaj   +1 more source

Galectin-9 expression clinically associated with mature dendritic cells infiltration and T cell immune response in colorectal cancer

BMC Cancer, 2022
Background Galectin-9 is a member of the galectin family and has been reported to have a tumor-promoting or antitumor effect in response to the immune microenvironment. However, the immunomodulatory effect of galectin-9 in colorectal cancer (CRC) remains
Yang Wang, Ruizhi Zheng, Yanhui Zhang, Yuhong Guo, Zhenzhen Hui, Peijing Wang, Yan Sun   +6 more
doaj   +1 more source

Reduced Expression of Galectin-9 Contributes to a Poor Outcome in Colon Cancer by Inhibiting NK Cell Chemotaxis Partially through the Rho/ROCK1 Signaling Pathway. [PDF]

PLoS ONE, 2016
Galectin-9 is a widely expressed protein that is involved in immune regulation and tumorpathogenesis and serves as a marker of a poor prognosis in various types of cancers.
Yang Wang, Jintang Sun, Chao Ma, Wenjuan Gao, Bingfeng Song, Hao Xue, Weiliang Chen, Xi Chen, Yun Zhang, Qianqian Shao, Qingjie Wang, Lei Zhao, Jia Liu, Xiuwen Wang, Huayang Wang, Yun Zhang, Meixiang Yang, Xun Qu   +17 more
doaj   +1 more source

Galectin Family Members: Emerging Novel Targets for Lymphoma Therapy?

Frontiers in Oncology, 2022
The galectin family of proteins has high affinity with β-galactoside-containing glycans. These proteins participate in cell growth and differentiation, cell adhesion, cell signal transduction, cell apoptosis, and other cellular activities.
Yuanwei Shi, Yuanwei Shi, Danting Tang, Danting Tang, Xiaoqi Li, Xiaoqi Li, Xiaoli Xie, Yufu Ye, Yufu Ye, Lijuan Wang, Lijuan Wang   +10 more
doaj   +1 more source

Galectin-9 ameliorates clinical severity of MRL/lpr lupus-prone mice by inducing plasma cell apoptosis independently of Tim-3. [PDF]

PLoS ONE, 2013
Galectin-9 ameliorates various murine autoimmune disease models by regulating T cells and macrophages, although it is not known what role it may have in B cells.
Masahiro Moritoki, Takeshi Kadowaki, Toshiro Niki, Daisuke Nakano, Genichiro Soma, Hirohito Mori, Hideki Kobara, Tsutomu Masaki, Masakazu Kohno, Mitsuomi Hirashima   +9 more
doaj   +1 more source