Results 91 to 100 of about 35,521 (207)

Circulating T Cells Exhibit Different TIM3/Galectin-9 Expression in Patients with Obesity and Obesity-Related Diabetes

Journal of Diabetes Research, 2020
Aims. Obesity is highly associated with type 2 diabetes mellitus (T2DM). The TIM3/galectin-9 pathway plays an important role in immune tolerance. Herein, we aimed to investigate the expression of TIM3 and galectin-9 in peripheral blood and to evaluate ...
Lili Sun, Shengyi Zou, Sisi Ding, Xuan Du, Yu Shen, Cuiping Liu, Bimin Shi, Xueguang Zhang   +7 more
doaj   +1 more source

Galectin-9-like from Angiostrongylus cantonensis young adult worms modulates eosinophil chemotaxis in vitro

Journal of Microbiology, Immunology and Infection, 2020
Background/purpose: Eosinophils are recruited to the brain of mice after infection with Angiostrongylus canonensis. Several factors produced by infected mice are well known playing the role to chemoattract eosinophils from the blood into the brain.
Jiun-Jye Wang, Zong-Sheng Wu, Li-Yu Chung, Chi-Yu Lu, Chuan-Min Yen   +4 more
doaj   +1 more source

Advanced extracellular vesicle immunotherapy

FlexMat, EarlyView.
A diagrammatic depiction of the therapeutic applicability of extracellular vesicles (EVs) in immunotherapy. This review explores the dual roles of tumor‐derived and immune cell‐derived EVs in cancer immunotherapy, discusses recent progress in EV engineering that improve their clinical utility, and evaluates their potential to augment existing ...
Jingjing Zhang, Yunfei Mu, Xianyue Ji, Xiaoting Jiang, Ruiheng Wang, Xianguang Ding, Lianhui Wang   +6 more
wiley   +1 more source

Association of TIM-1 5383-5397ins/del and TIM-3-1541C > T polymorphisms with multiple sclerosis in Isfahan population [PDF]

, 2016
Multiple sclerosis (MS) is an organ-specific autoimmune disease in central nervous system, affecting about 2.5 million people around the world. Probable involvement of two newly identified immunoregulator molecules, TIM-1 and TIM-3, has been reported in ...
Alesahebfosoul, Fereshteh., Etemadifar, Masoud., Ganjalikhani-Hakemi, Mazdak., Mazrouei, Fariba., Meshkat, Rezvan., Nekoueian, Sh., Pouladian, Majid., Salehi, Rasoul., Zarkesh Esfahani, Hamid., Ziyaee-Ghahnaviyeh, M.   +9 more
core   +1 more source

Exploring Immune Development in Infants With Moderate to Severe Atopic Dermatitis [PDF]

, 2018
Background: Atopic dermatitis (AD) is the most common chronic inflammatory skin disease in infancy with a complex pathology. In adults, the clinical severity of AD has been associated with increases in T helper cell type (Th) 2, Th22, and Th17 serum ...
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core   +1 more source

Strategies for Monitoring Serum Protein Degradation With an Antibody Array‐Based Technology

Journal of Clinical Laboratory Analysis, EarlyView.
This study analyzed the stability of 480 proteins in human serum samples collected from 10 healthy donors and incubated at room temperature for 0–48 h. Antibody array profiling revealed significant time‐dependent degradation of 201 proteins. Subsequent physicochemical and functional enrichment analyses demonstrated that the degraded proteins were ...
Yanlin Wang, Min Lang, Wei Huang, Siwei Zhu, Yingqing Mao, Shuhong Luo, Hua Dong, Ruo‐Pan Huang   +7 more
wiley   +1 more source

The therapeutic potential of the filarial nematode-derived immunodulator, ES-62 in inflammatory disease [PDF]

, 2010
The dramatic recent rise in the incidence of allergic or autoimmune inflammatory diseases in the West has been proposed to reflect the lack of appropriate priming of the immune response by infectious agents such as parasitic worms during childhood ...
Al-Riyami, Al-Riyammi, Aoyama, Baev, Bashir, Bogoyevitch, Borghouts, Bowdish, Bowdish, Bradley, Brattig, Burke, Burke, Burke, Busse, Calpe, Choubey, Clutter, Cooper, Couper, Croese, Dagia, Deehan, Diaz, Dittrich, Divangahi, Elliott, Elliott, Elliott, Everts, Fabriek, Falcone, Fulkerson, Goodridge, Goodridge, Goodridge, Goodridge, Goodridge, Gu, Hamerman, Harnett, Harnett, Harnett, Harnett, Harnett, Harnett, Harnett, Harnett, Harnett, He, Houston, Hunter, Ishibashi, Jayapal, Johnson, Kakinuma, Katschke, Kean, Khan, Kim, King, Kitagaki, Kuroki, Lai, Lai, Lamb, Lubberts, Maizels, Mansoor, Marshall, Maurer, McInnes, McInnes, Melendez, Mendoza, Mi, Mori, Moriyama, Moriyama, Moriyama, Nagel-Wolfrum, Node, Page, Polfliet, Pushparaj, Pushparaj, Rajan, Reddy, Rioja, Rogers, Satoh, Saunders, Schnoeller, Schramm, Schramm, Steinfelder, Strickland, Subramanian, Suciu-Foca, Thalhamer, Thomas, Tilstra, van Riet, Wang, Wang, WHO, Wills-Karp, Wilson, Wohlleben, Wong, Wray, Zaccone   +111 more
core   +2 more sources

Quantifying Protein–Glycan Interactions Using Native Mass Spectrometry

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Interactions between glycan‐binding proteins (GBPs) and carbohydrates (glycans) are essential to many biological processes relevant to human health and disease. For most GBPs, however, their glycan interactome—the repertoire of glycans recognized and their specificities—is poorly defined.
Duong T. Bui, Elena N. Kitova, Ling Han, Lara K. Mahal, John S. Klassen   +4 more
wiley   +1 more source

Alarmin function of galectin-9 in murine respiratory tularemia.

PLoS ONE, 2015
Sepsis is a complex immune disorder that is characterized by systemic hyperinflammation. Alarmins, which are multifunctional endogenous factors, have been implicated in exacerbation of inflammation in many immune disorders including sepsis.
Anthony L Steichen, Tanner J Simonson, Sharon L Salmon, Dennis W Metzger, Bibhuti B Mishra, Jyotika Sharma   +5 more
doaj   +1 more source

T Helper Cells Fate Mapping by Co-stimulatory Molecules and its Functions in Allograft Rejection and Tolerance [PDF]

, 2014
T cell differentiation is dictated by a combination of T cell receptor (TCR) interaction with an antigen-bound major histocompatibility complex (MHC), and co-stimulatory molecules signal.
Abdoli, R., Najafian, N.
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