Results 61 to 70 of about 35,521 (207)

Increased Blood Flow and Tendon Swelling Precedes Vascular Expansion and Tissue Matrix Changes In Early Human Tendinopathy: A Potential Window for Superior Treatment Response

Advanced Science, EarlyView.
Human participants with early‐ or chronic‐stage tendinopathy and healthy controls are investigated using ultrasound Doppler, 3T and 7T MRI, and tendon biopsies. Tendon swelling and hyperperfusion are evident early, while vascular growth and extracellular matrix changes are most pronounced in chronic tendinopathy. Early intervention may provide superior
Max F. R. Merkel, Nikolaj M. Malmgaard‐Clausen, Marius Lendal, Hartwig R. Siebner, René B. Svensson, Stephanie G. Dakin, Marcus Krüger, Luisa Schmidt, Jakob Agergaard, Ching‐Yan Chloé Yeung, S. Peter Magnusson, Michael Kjaer   +11 more
wiley   +1 more source

Surface Avidity of Anionic Polypeptide Coatings on Layer‐by‐Layer Nanoparticles Target Cancer‐Associated Amino Acid Transporters

Angewandte Chemie International Edition, EarlyView.
Electrostatically layered nanoparticles (NPs) coated with anionic polypeptides selectively target cancer cells by engaging amino acid transporters. Poly(L‐glutamate) (PLE) coatings cluster the glutamine transporter SLC1A5, prolonging NP surface retention, while poly(L‐aspartate) (PLD) coatings also bind SLC1A3, potentially promoting faster ...
Ivan S. Pires, Margaret M. Billingsley, Ezra Gordon, Andrew J. Pickering, Eva Cai, Gonzalo J. Esparza, Mae L. Pryor, Alexander D. Stoneman, Aidan Kindopp, Darrell J. Irvine, Paula T. Hammond   +10 more
wiley   +2 more sources

Glycobiology of cell death: when glycans and lectins govern cell fate [PDF]

, 2013
Although one typically thinks of carbohydrates as associated with cell growth and viability, glycosylation also has an integral role in many processes leading to cell death.
A Büssing, A Shiratsuchi, A Sturm, AF Carlin, AF Swindall, B Brandt, BE Britigan, BN Stillman, C Lazar, C Villeneuve, C Zhu, CA Gabel, CF Brewer, D Paclik, E Cao, E Charlier, E Duvall, E Rapoport, EM Rapoport, F Bernerd, F Dall’Olio, F Gu, F Yu, FA Barr, FT Liu, G A Rabinovich, G Ion, G Majai, G Yogalingam, GA Rabinovich, GA Rabinovich, GA Rabinovich, GA Rabinovich, GA Rabinovich, GA Rabinovich, GC Fernández, GD Griffiths, GR Vasta, H Ise, H Sano, H Sano, HM Meesmann, HP Hahn, I Bournazou, I Kuwabara, JA Fulcher, JD Hernandez, JD Marth, JF Kerr, JH Lin, JT Nguyen, K Kollmann, K Lauber, K Moriwaki, K Moriwaki, K Suzuki, KE Pace, KW Wagner, L Eshkar Sebban, LA Earl, LC Paessens, LH Lu, LL Fu, M Cohen, M Dias-Baruffi, M Molinari, M Pang, M Rangachari, MA Toscano, MC Maiuri, ME Peter, ML Litvack, MM Fuster, MM Weck, MU Hutchins, N Maugeri, N Mazurek, N Mazurek, N Mazurek, N Oka, N Sharon, NB Caberoy, OM Shatnyeva, OT Keppler, P Desharnais, P Matarrese, P Schneider, P Smits, R G Lichtenstein, R Hanayama, R Hanayama, RA Lockshin, RG Morris, RS Maag, RY Yang, S Arur, S Eda, S Gupta, S Li, S Mukherjee, S Toda, S Wesselborg, SC Starossom, SJ Van Dyken, SJ Van Vliet, SR Stowell, SR Stowell, T Fukumori, T Fukumori, TL Schagat, TL Thurston, V Wells, VA Fadok, VM Abrahams, X Li, Y Kashio, Y Oda, Y Wang, Y Watanabe, Y Watanabe, Y Zhuo, YJ Lee, Z Liu, ZN Oltvai   +123 more
core   +2 more sources

GALNT10 Affects O‐Glycosylation of IGFBP7 to Promote Tumor Vascular Remodeling and Metastasis of Ovarian Cancer

Advanced Science, EarlyView.
The glycosyltransferase GALNT10 facilitates ovarian cancer metastasis through the induction of tumor cell EMT and tumor vascular dysfunction. GALNT10 enhanced the extracellular secretion of IGFBP7 through O‐GalNAc glycosylation modification at the T188 site, which subsequently interacts with CD93 on endothelial cells, leading to vascular remodeling ...
Yanan Zhang, Ayala Zuha, Zhangxin Wu, Aiping Luo, Bixia Jin, Qinkun Sun, Yuan Li, Qiyu Liu, Hongyan Guo, Chunliang Shang   +9 more
wiley   +1 more source

Galectin‐9 and myeloid‐derived suppressor cell as prognostic indicators for chronic lymphocytic leukemia

Immunity, Inflammation and Disease, 2023
Background Galectin‐9 and myeloid‐derived suppressor cells (MDSCs) have an important role in tumors, but their clinical values in chronic lymphocytic leukemia (CLL) have not been fully elucidated.
Xierenguli Alimu, Juan Zhang, Nannan Pang, Rui Zhang, Rong Chen, Xuejiao Zeng, Shabaaiti Tudahong, Gang Chen, Maliya Muhashi, Fang Zhao, Jianbing Ding, Jianhua Qu   +11 more
doaj   +1 more source

Biomimetic Membrane Interface Technologies for Detection and Isolation of CTCs and EVs: Advances and Opportunities in Liquid Biopsy

Advanced Science, EarlyView.
Biomimetic membrane interface engineering constructs functionalized detection platforms by integrating natural cell membranes, synthetic lipids, or hybrid membranes. This strategy effectively reduces background interference and enables efficient target capture and analysis, showing broad applications in circulating tumor cell separation, extracellular ...
Duo Liu, Jie Yu, Jingxue Li, Yixue Chen, Mengle Peng, Yifan Xu, Yongjun Wu, Lihua Ding, Sitian He   +8 more
wiley   +1 more source

Periodontal diseases and adverse pregnancy outcomes. Present and future

Periodontology 2000, EarlyView., 2023
Abstract For more than two decades the possible association between periodontal diseases and adverse pregnancy outcomes has been extensively evaluated. Numerous observational, intervention, and mechanistic studies have offered valuable information on this topic.
Yiorgos A. Bobetsis, Mark Ide, Mervi Gürsoy, Phoebus N. Madianos   +3 more
wiley   +1 more source

PAX4 preserves endoplasmic reticulum integrity preventing beta cell degeneration in a mouse model of type 1 diabetes mellitus [PDF]

, 2016
[Aims/hypothesis]: A strategy to enhance pancreatic islet functional beta cell mass (BCM) while restraining inflammation, through the manipulation of molecular and cellular targets, would provide a means to counteract the deteriorating glycaemic control ...
Cobo Vuilleumier, Nadia, Fuente Martín, Esther, Gauthier, Benoit R., Gracia Herrera Gómez, Irene de, Jiménez Moreno, Carmen María, Lorenzo, Petra I., López Noriega, Livia, Martín Montalvo, Alejandro, Mellado Gil, José Manuel, Quesada, Iván, Álvarez Mercado, Anabel   +10 more
core   +1 more source

Ligand‐Induced Electronic Response Enables Predictive QM/MM Simulations

Advanced Science, EarlyView.
Quantum mechanics/molecular mechanics (QM/MM) simulations are powerful tools for modeling complex molecular systems; however, their predictability has been constrained by the ambiguous definition of the QM region. An electronically informed protocol is introduced that defines QM regions by quantifying guest‐induced orbital shifts and charge ...
Nichika Ozawa, Nahoko Kuroki, Hirotoshi Mori   +2 more
wiley   +1 more source

The Tim-3-Galectin-9 Pathway and Its Regulatory Mechanisms in Human Breast Cancer

Frontiers in Immunology, 2019
Human cancer cells operate a variety of effective molecular and signaling mechanisms which allow them to escape host immune surveillance and thus progress the disease.
Inna M. Yasinska, Svetlana S. Sakhnevych, Ludmila Pavlova, Anette Teo Hansen Selnø, Ana Maria Teuscher Abeleira, Ana Maria Teuscher Abeleira, Ouafa Benlaouer, Isabel Gonçalves Silva, Marianne Mosimann, Marianne Mosimann, Luca Varani, Marco Bardelli, Rohanah Hussain, Giuliano Siligardi, Dietmar Cholewa, Steffen M. Berger, Bernhard F. Gibbs, Bernhard F. Gibbs, Yuri A. Ushkaryov, Elizaveta Fasler-Kan, Elizaveta Fasler-Kan, Elena Klenova, Vadim V. Sumbayev   +22 more
doaj   +1 more source