Results 91 to 100 of about 4,689,501 (274)

CXC chemokine ligand 13 and galectin-9 plasma levels collaboratively provide prediction of disease activity and progression-free survival in chronic lymphocytic leukemia

Annals of Hematology, 2023
The clinical outcome of lymphocytic leukemia (CLL) is quite heterogeneous. The purpose of this observational study was to investigate the clinical merit of measuring plasma galectin-9 and CXCL-13 concentrations as predictors of CLL activity, prognosis ...
Heba A Ahmed, A. Nafady, E. H. Ahmed, Emad Eldin Nabil Hassan, W. Soliman, Mahmoud I Elbadry, A. A. Allam   +6 more
semanticscholar   +1 more source

Correlation between serum galectin‐9 levels and liver fibrosis [PDF]

Journal of Gastroenterology and Hepatology, 2018
AbstractBackground and AimChronic liver diseases progress from chronic inflammation to fibrosis to tumorigenesis. Galectin‐9, a β‐galactoside‐specific animal lectin, is indicated to contribute to all three steps of progression. The aim of this study was to determine which of the three steps was most dominant in elevating the serum galectin‐9 ...
Koji, Fujita, Toshiro, Niki, Takako, Nomura, Kyoko, Oura, Tomoko, Tadokoro, Teppei, Sakamoto, Joji, Tani, Hirohito, Yoneyama, Asahiro, Morishita, Noriyuki, Kuroda, Takeshi, Arai, Naoki, Nishimoto, Takashi, Himoto, Mitsuomi, Hirashima, Tsutomu, Masaki   +14 more
openaire   +2 more sources

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

Lactate secreted by PKM2 upregulation promotes Galectin-9-mediated immunosuppression via inhibiting NF-κB pathway in HNSCC

Cell Death and Disease, 2021
Pyruvate kinase M2 as a key rate-limiting enzyme in glycolysis, it plays a critical role in metabolic reprogramming and carcinogenesis. However, whether PKM2 can promote immunosuppressive microenvironment formation remains unknown in head and neck ...
Hanyue Chang, Qiaoshi Xu, Jiayi Li, Mingyu Li, Zhiyuan Zhang, Hailong Ma, Xi Yang   +6 more
doaj   +1 more source

A Testis‐Specific Aralkylamine N‐Acetyltransferase Regulates Dimorphic Sperm Function and Male Fertility in Moths

Advanced Science, EarlyView.
We identify a Lepidoptera‐conserved testis‐specific arylalkylamine N‐acetyltransferase (LTNAT) that governs male moth fertility via a novel mechanism. LTNAT loss disrupts eupyrene sperm mitochondrial derivatives and impairs apyrene sperm motility, offering a safe molecular target for innovative pesticides and genetic pest control.
Hao Sun, Peng‐Yi Huang, Zhi‐Ruo Zhang, Cong‐Fen Gao, Subba Reddy Palli, Shun‐Fan Wu   +5 more
wiley   +1 more source

Towards a Better Understanding of the Relationships between Galectin-7, p53 and MMP-9 during Cancer Progression

Biomolecules, 2021
It has been almost 25 years since the discovery of galectin-7. This member of the galectin family has attracted interest from many working in the cancer field given its highly restricted expression profile in epithelial cells and the fact that cancers of
Yves St-Pierre
doaj   +1 more source

Galectin-3 not Galectin-9 as a candidate prognosis marker for hepatocellular carcinoma [PDF]

PeerJ, 2020
Background Galectins (Gal) are a family of protein that bind to the β-galactoside of glycoproteins. It modulates a variety of biological functions, such as tumor growth, angiogenesis and tumor metastasis.
Fei Kong, Meishan Jin, Donghui Cao, Zhifang Jia, Yawen Liu, Jing Jiang   +5 more
doaj   +2 more sources

PAX4 preserves endoplasmic reticulum integrity preventing beta cell degeneration in a mouse model of type 1 diabetes mellitus [PDF]

, 2016
[Aims/hypothesis]: A strategy to enhance pancreatic islet functional beta cell mass (BCM) while restraining inflammation, through the manipulation of molecular and cellular targets, would provide a means to counteract the deteriorating glycaemic control ...
Cobo Vuilleumier, Nadia, Fuente Martín, Esther, Gauthier, Benoit R., Gracia Herrera Gómez, Irene de, Jiménez Moreno, Carmen María, Lorenzo, Petra I., López Noriega, Livia, Martín Montalvo, Alejandro, Mellado Gil, José Manuel, Quesada, Iván, Álvarez Mercado, Anabel   +10 more
core   +1 more source

Obesity-induced galectin-9 is a therapeutic target in B-cell acute lymphoblastic leukemia

Nature Communications, 2022
The incidence of obesity is rising with greater than 40% of the world’s population expected to be overweight or suffering from obesity by 2030. This is alarming because obesity increases mortality rates in patients with various cancer subtypes including ...
Miyoung Lee, Jamie A. G. Hamilton, G. Talekar, Anthony J. Ross, L. Michael, Manali Rupji, Bhakti Dwivedi, Sunil S. Raikar, J. Boss, Christopher D. Scharer, D. Graham, D. DeRyckere, C. Porter, C. Henry   +13 more
semanticscholar   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source