Results 101 to 110 of about 4,689,501 (274)

Periodontal diseases and adverse pregnancy outcomes. Present and future

Periodontology 2000, EarlyView., 2023
Abstract For more than two decades the possible association between periodontal diseases and adverse pregnancy outcomes has been extensively evaluated. Numerous observational, intervention, and mechanistic studies have offered valuable information on this topic.
Yiorgos A. Bobetsis, Mark Ide, Mervi Gürsoy, Phoebus N. Madianos   +3 more
wiley   +1 more source

Targeting the Immune Checkpoint in Cancer: Is This a Viable Treatment Option for AML? [PDF]

, 2018
The immune suppressive mechanisms displayed by malignant cells are considered a central process in the pathogenesis of cancer. Research in this area has gained significant momentum over the past 20 years, with several immune checkpoints identified ...
Coles, Steven
core   +1 more source

Expression of TIM3/VISTA checkpoints and the CD68 macrophage-associated marker correlates with anti-PD1/PDL1 resistance: implications of immunogram heterogeneity. [PDF]

, 2020
Although immunotherapies have achieved remarkable salutary effects among subgroups of advanced cancers, most patients do not respond. We comprehensively evaluated biomarkers associated with the "cancer-immunity cycle" in the pan-cancer setting in order ...
Dressman, Devin, Eskander, Ramez, Glenn, Sean T, Goodman, Aaron, Ikeda, Sadakatsu, Kato, Shumei, Kumaki, Yuichi, Kurzrock, Razelle, Lee, Suzanna, Lenzo, Felicia L, Morrison, Carl, Nikanjam, Mina, Okamura, Ryosuke, Papanicolau-Sengos, Antonios   +13 more
core   +1 more source

Activated Galectin‐9/Tim3 promotes Treg and suppresses Th1 effector function in chronic lymphocytic leukemia

The FASEB Journal, 2021
Tim‐3 is a negative immunoregulator in anti‐tumor response, but its mechanism in chronic lymphocytic leukemia (CLL) is not yet clear. The aim of this study was to understand the role of Galectin‐9/Tim‐3 signaling pathway in the regulation of CD4+ T cell ...
N. Pang, Xierenguli Alimu, Rong Chen, Maliya Muhashi, Jiajia Ma, Gang Chen, Fang Zhao, Lei Wang, Jian-hua Qu, Jianbang Ding   +9 more
semanticscholar   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Glycobiology of cell death: when glycans and lectins govern cell fate [PDF]

, 2013
Although one typically thinks of carbohydrates as associated with cell growth and viability, glycosylation also has an integral role in many processes leading to cell death.
A Büssing, A Shiratsuchi, A Sturm, AF Carlin, AF Swindall, B Brandt, BE Britigan, BN Stillman, C Lazar, C Villeneuve, C Zhu, CA Gabel, CF Brewer, D Paclik, E Cao, E Charlier, E Duvall, E Rapoport, EM Rapoport, F Bernerd, F Dall’Olio, F Gu, F Yu, FA Barr, FT Liu, G A Rabinovich, G Ion, G Majai, G Yogalingam, GA Rabinovich, GA Rabinovich, GA Rabinovich, GA Rabinovich, GA Rabinovich, GA Rabinovich, GC Fernández, GD Griffiths, GR Vasta, H Ise, H Sano, H Sano, HM Meesmann, HP Hahn, I Bournazou, I Kuwabara, JA Fulcher, JD Hernandez, JD Marth, JF Kerr, JH Lin, JT Nguyen, K Kollmann, K Lauber, K Moriwaki, K Moriwaki, K Suzuki, KE Pace, KW Wagner, L Eshkar Sebban, LA Earl, LC Paessens, LH Lu, LL Fu, M Cohen, M Dias-Baruffi, M Molinari, M Pang, M Rangachari, MA Toscano, MC Maiuri, ME Peter, ML Litvack, MM Fuster, MM Weck, MU Hutchins, N Maugeri, N Mazurek, N Mazurek, N Mazurek, N Oka, N Sharon, NB Caberoy, OM Shatnyeva, OT Keppler, P Desharnais, P Matarrese, P Schneider, P Smits, R G Lichtenstein, R Hanayama, R Hanayama, RA Lockshin, RG Morris, RS Maag, RY Yang, S Arur, S Eda, S Gupta, S Li, S Mukherjee, S Toda, S Wesselborg, SC Starossom, SJ Van Dyken, SJ Van Vliet, SR Stowell, SR Stowell, T Fukumori, T Fukumori, TL Schagat, TL Thurston, V Wells, VA Fadok, VM Abrahams, X Li, Y Kashio, Y Oda, Y Wang, Y Watanabe, Y Watanabe, Y Zhuo, YJ Lee, Z Liu, ZN Oltvai   +123 more
core   +2 more sources

Galectin-9 recognizes and exhibits antimicrobial activity toward microbes expressing blood group–like antigens

Journal of Biological Chemistry, 2022
While adaptive immunity recognizes a nearly infinite range of antigenic determinants, immune tolerance renders adaptive immunity vulnerable to microbes decorated in self-like antigens.
Anna V. Blenda, N. Kamili, Shang-Chuen Wu, William F. Abel, Diyoly Ayona, Christian Gerner-Smidt, A. Ho, G. Benian, R. Cummings, C. Arthur, S. Stowell   +10 more
semanticscholar   +1 more source

Galectin-9: An anticancer molecule for gallbladder carcinoma

International Journal of Oncology, 2016
Gallbladder cancer (GBC) is the most common and aggressive type of biliary tract cancer. There are various histological types of GBC, and the vast majority of GBC cases are adenocarcinomas. Squamous and adenosquamous carcinomas are rare GBC subtypes that are traditionally considered to be more aggressive and to be associated with a poorer prognosis ...
Tomoko, Tadokoro, Asahiro, Morishita, Shintaro, Fujihara, Hisakazu, Iwama, Toshiro, Niki, Koji, Fujita, Emiko, Akashi, Shima, Mimura, Kyoko, Oura, Teppei, Sakamoto, Takako, Nomura, Joji, Tani, Hisaaki, Miyoshi, Hirohito, Yoneyama, Takashi, Himoto, Mitsuomi, Hirashima, Tsutomu, Masaki   +16 more
openaire   +3 more sources

Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion

Advanced Science, EarlyView.
The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li, Yuanxin Li, Asif Rashid, Hong Kee Tan, Shing Chan, Man Yan Hui, Wilson Yau Ki Chan, Kee See Lam, Yinping Liu, Wenwei Tu, Wing Leung   +10 more
wiley   +1 more source

The Tim-3-Galectin-9 Pathway and Its Regulatory Mechanisms in Human Breast Cancer

Frontiers in Immunology, 2019
Human cancer cells operate a variety of effective molecular and signaling mechanisms which allow them to escape host immune surveillance and thus progress the disease.
Inna M. Yasinska, Svetlana S. Sakhnevych, Ludmila Pavlova, Anette Teo Hansen Selnø, Ana Maria Teuscher Abeleira, Ana Maria Teuscher Abeleira, Ouafa Benlaouer, Isabel Gonçalves Silva, Marianne Mosimann, Marianne Mosimann, Luca Varani, Marco Bardelli, Rohanah Hussain, Giuliano Siligardi, Dietmar Cholewa, Steffen M. Berger, Bernhard F. Gibbs, Bernhard F. Gibbs, Yuri A. Ushkaryov, Elizaveta Fasler-Kan, Elizaveta Fasler-Kan, Elena Klenova, Vadim V. Sumbayev   +22 more
doaj   +1 more source