Results 151 to 160 of about 4,689,501 (274)

Modulators of the Balance between M1 and M2 Macrophages during Pregnancy [PDF]

, 2017
Macrophages are a subset of mononuclear phagocytes of the innate immune system with high plasticity and heterogeneity. At the maternal–fetal interface, macrophages are present in all stages of pregnancy and involved in a variety of activities, including ...
Ai-Hua Liao, Ming He, Yan Wang, Yong-Hong Zhang   +3 more
core   +1 more source

Quantifying Protein–Glycan Interactions Using Native Mass Spectrometry

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Interactions between glycan‐binding proteins (GBPs) and carbohydrates (glycans) are essential to many biological processes relevant to human health and disease. For most GBPs, however, their glycan interactome—the repertoire of glycans recognized and their specificities—is poorly defined.
Duong T. Bui, Elena N. Kitova, Ling Han, Lara K. Mahal, John S. Klassen   +4 more
wiley   +1 more source

Comprehensive Insights into Natural Bioactive Compounds: From Chemical Diversity and Mechanisms to Biotechnological Innovations and Applications

ChemistryOpen, EarlyView.
Natural products derived from plants, animals, fungi, bacteria, and minerals contain diverse bioactive classes such as alkaloids, flavonoids, terpenoids, saponins, tannins, and phenolics. These natural products work through different mechanisms, including ROS inhibition, NF‐κB suppression, and cytokine regulation, and exhibit wide applications across ...
Sajid Ali, Atif Ali Khan Khalil, Muhammad Saeed Akhtar, Adnan Amin, Wajid Zaman   +4 more
wiley   +1 more source

Interrogation of glioma immune microenvironment identifies a non-canonical role for microglial Galectin-9 in tumor cell adhesion and phagocytosis

Frontiers in Immunology
Glioma-associated microglia/macrophages (GAMs) have traditionally been described as immunosuppressive. However, within their highly heterogeneous repertoire, pro-phagocytic and cytotoxic subsets with anti-tumoral properties exist.
Pravesh Gupta, Silvana Valdebenito-Silva, Gayatri Kumar, Prashanth Chakrapani, Shivangi Oberai, Shivangi Oberai, Minghao Dang, Hiroshi Katayama, Linghua Wang, Linghua Wang, Linghua Wang, Linghua Wang, Eliseo A. Eugenin, Krishna P. Bhat   +13 more
doaj   +1 more source

SPROUTS_DB: An Implemented Database of Contaminants for Extracellular Vesicle Proteomics Studies

PROTEOMICS, EarlyView.
ABSTRACT Current proteomics techniques allow rapid identification and quantification of proteins within any given biological source. However, LC–MS/MS proteomics is vulnerable to laboratory and sample‐associated contaminants. Therefore, accurate identification and annotation of such contaminants is crucial for development of reliable databases ...
Maria Gaetana Giovanna Pittalà, Loredana Leggio, Greta Paternò, Elena Giusto, Laura Civiero, Vincenzo Cunsolo, Silvia Vivarelli, Antonella Di Francesco, Emanuele Alpi, Nunzio Iraci, Rosaria Saletti   +10 more
wiley   +1 more source

Targeting the C-terminus of galectin-9 induces mesothelioma apoptosis and M2 macrophage depletion

OncoImmunology, 2019
Galectin-9 has emerged as a promising biological target for cancer immunotherapy due to its role as a regulator of macrophage and T-cell differentiation. In addition, its expression in tumor cells modulates tumor cell adhesion, metastasis, and apoptosis.
Pietro Bertino, Thomas A. Premeaux, Tsuyoshi Fujita, Brien K. Haun, Michael P. Marciel, Fukun W. Hoffmann, Alan Garcia, Haining Yiang, Sandra Pastorino, Michele Carbone, Toshiro Niki, John Berestecky, Peter R. Hoffmann, Lishomwa C. Ndhlovu   +13 more
doaj   +1 more source

Az anya immunológiai tolerancia mechanizmusai a terhesség során és azok zavarai pathológiás terhességekben: pre-eclampsiás és habituálisan vetélő betegek vizsgálata = The mechanisms of immunological tolerance during pregnancy: impaired maternal tolerance during pre-eclampsia and habitual abortion [PDF]

, 2011
Sikeres és sikertelen mesterséges megtermékenyítésen (IVF) átesett nők perifériás NK és NKT sejtjeinek fenotípusát és funkcióját vizsgáltuk. Követéses vizsgálat során a beavatkozás előtt és után nyert adatokat hasonlítottuk össze.
Barakonyi, Aliz, Halász, Melinda, Mikó, Éva, Szereday, László   +3 more
core  

Interferon-stimulated gene (ISG)-expression screening reveals the specific antibunyaviral activity of ISG20 [PDF]

, 2018
Bunyaviruses pose a significant threat to human health, prosperity and food security. In response to viral infections, interferons (IFNs) upregulate the expression of hundreds of interferon stimulated genes (ISGs) whose cumulative action can potently ...
Bieniasz, Paul D., Brennan, Benjamin, Elliott, Richard M., Feng, Junjie, Koudriakova, Elina, Kreher, Felix, Rezelj, Veronica V., Rice, Charles M., Rihn, Suzannah J., Shaw, Andrew E., Shi, Xiaohong, Slack, Gillian S., Tilston-Lunel, Natasha L., Turnbull, Matthew L., Wickenhagen, Arthur, Wilson, Sam J.   +15 more
core   +1 more source

Enhancement of immune checkpoint inhibitor efficacy by DHX58+ SELL+ T cells in advanced gastric cancer

VIEW, EarlyView.
We created a coculture system using patient‐derived organoids (PDOs) and tumor‐infiltrating lymphocytes (TILs) that mimics important interactions between PDOs and TILs in the presence of various ICIs. Our findings reveal that CD62L+ T cells, activated by CD44+ cancer stem cells (CSCs), facilitate tumor regression in samples sensitive to ICIs, which is ...
Jie Chen, Youdong Liu, Hongda Pan, Tianyi Cai, Mingde Zang, Xiaowen Liu, Ziwen Long, Xin Fan, Jun Lu, Fenglin Liu   +9 more
wiley   +1 more source

Liver eosinophilic infiltrate is a significant finding in patients with chronic hepatitis C. [PDF]

, 2008
Eosinophilic infiltrate of liver tissue is described in primary cholestatic diseases, hepatic allograft rejection and drug-induced liver injury, but its significance and its implications in chronic hepatitis C are unknown.
ALESSI, N, CABIBI, Daniela, CAMMA', Calogero, CRAXI, Antonio, DI MARCO, Vito, DONATELLI, Maria, PETTA, Salvatore, TARANTINO, Giuseppe   +7 more
core   +1 more source