Results 191 to 200 of about 4,219,302 (284)

Biological Templates for Gold Nanocluster Assembly: Design and Biomedical Applications

Aggregate, Volume 7, Issue 2, February 2026.
The review discusses the fundamental properties of ultrasmall gold nanoclusters and their surface modification strategies for targeted biomedical use. It examines biologically guided assembly processes and their effects on optical behavior, particularly aggregation‐induced emission.
Zeineb Ayed, Abdallah Alhalabi, Didier Gasparutto, Xavier Le Guével   +3 more
wiley   +1 more source

Targeted blood proteome profiling using NULISAseq identifies a high‐performance biomarker panel for Aβ pathology quantification and staging

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION While current blood‐based biomarkers for Alzheimer's disease (AD) are effective for determining amyloid beta (Aβ) pathology positivity/negativity, they are insufficient for quantifying Aβ plaque deposition. METHODS We profiled 325 plasma proteins in a Hong Kong Chinese cohort using the Nucleic Acid Linked Immuno‑Sandwich Assay ...
Wenyue Zheng, Yuanbing Jiang, Hiu Yi Wong, Wan Wa Wong, Lily K. W. Cheng, Elaine Y. L. Cheng, Bonnie W. Y. Wong, Ronnie M. N. Lo, Siu Ki Leung, Fanny C. Ip, Jacqueline K. Y. Yuen, Yat Fung Shea, Wai Ming Wong, Chun Keung Shum, Hok Man Wai, Vincent C. T. Mok, Timothy C. Y. Kwok, Kin Y. Mok, Amanda Heslegrave, John Hardy, Henrik Zetterberg, Amy K. Y. Fu, Nancy Y. Ip   +22 more
wiley   +1 more source

T‐cell exhaustion from a multiomics perspective: Differentiation mechanisms and regulatory networks in the journey from progenitor‐Exhausted T cells to terminally exhausted T cells

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
(1) Core Process: Persistent antigen, from TDLNs to TME, drives Tpex → Tex‐int → Tex‐term differentiation. (2) Multiomics Regulation: This fate transition is orchestrated by a co‐ordinated, multi‐layered molecular network. (3) Functional Outcome: Dysregulated signalling and surging co‐inhibitory receptors lock in proliferative arrest and functional ...
Tong Zhu, Xiaoyu Teng, Qinlian Jiao, Yidan Ren, Yunshan Wang, Maoxiao Feng   +5 more
wiley   +1 more source

Intranasal Human NSC‐Derived EVs Therapy Can Restrain Inflammatory Microglial Transcriptome, and NLRP3 and cGAS‐STING Signalling, in Aged Hippocampus

Journal of Extracellular Vesicles, Volume 15, Issue 2, February 2026.
ABSTRACT Neuroinflammaging, a moderate, chronic, and sterile inflammation in the hippocampus, contributes to age‐related cognitive decline. Neuroinflammaging comprises the activation of the nucleotide‐binding domain, leucine‐rich repeat family, and pyrin domain‐containing 3 (NLRP3) inflammasomes, and the cyclic GMP‐AMP synthase (cGAS)‐stimulator of ...
Leelavathi N. Madhu, Maheedhar Kodali, Shama Rao, Sahithi Attaluri, Raghavendra Upadhya, Goutham Shankar, Bing Shuai, Yogish Somayaji, Shruthi V. Ganesh, Vignesh S. Kumar, Jeswin E. James, Padmashri A. Shetty, Avery LeMaire, Xiaolan Rao, James J Cai, Ashok K. Shetty   +15 more
wiley   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source

Peripheral Nerves in Cancer: Regulatory Roles and Therapeutic Strategies

MedComm, Volume 7, Issue 2, February 2026.
The interaction between cancer cells and peripheral nerves: (1) tumor cells could induce the growth of new neural axons and constructing a neural fiber network within the tumor tissue through secreting nerve growth factors; (2) nerve‐derived bioactive molecules can induce perineural invasion of tumor and regulate the malignant phenotype of tumor, such ...
Yan Fu, Zhi‐Shan Ge, Qing‐Yue Cao, Zi‐Han Li, An Zhang, Hai‐Dong Zhu, Gao‐Jun Teng   +6 more
wiley   +1 more source

Tumor‐Associated Macrophages as Therapeutic Targets: Deciphering Interaction Networks and Advancing Clinical Translation

MedComm, Volume 7, Issue 2, February 2026.
Tumor‐associated macrophages are the most abundant immune cells in the tumor microenvironment, driving malignant progression and treatment resistance. This review summarizes the protumor mechanisms of TAMs (including phagocytosis modulation, metabolic reprogramming, exosomal communication, and immune interactions), evaluates three major strategies ...
Wurihan Bao, Xiaojie Qu, Yiqi Wang, Dan Huang, Huiling Zhang, Mingyuan Dong, Han Sun, Zhaogang Yang, Xuefeng Li   +8 more
wiley   +1 more source

Galectin-9-An Emerging Glyco-Immune Checkpoint Target for Cancer Therapy. [PDF]

Int J Mol Sci
Karkempetzaki AI, Schatton T, Barthel SR.   +2 more
europepmc   +1 more source

Bone Metastasis: Molecular Mechanisms, Clinical Management, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
This figure emphasizes current understanding of the regulatory networks, approach of diagnose, available preclinical models and clinical management of bone metastasis. to guide future therapeutic development. A deep understanding of these aspects enables the prevention of bone metastasis and the implementation of effective therapeutic strategies ...
Jingyuan Wen, Binghua Li, Shengjia Wang, Yongzhong Yao, Zhao Huang, Decai Yu   +5 more
wiley   +1 more source

Fluorophore Modulates Intracellular Distribution of Enzyme‐Instructed Self‐Assembly of Short Peptides in Osteosarcoma Cells

Small Methods, Volume 10, Issue 3, 9 February 2026.
Fluorophores at the peptide C‐terminus reprogram EISA behavior in osteosarcoma cellsshifting ER vs mitochondrial targeting, altering assembly, and tuning cytotoxicity. Abstract Enzyme‐instructed self‐assembly (EISA) of peptides offers a versatile strategy for developing intracellular nanomedicines, yet the role of C‐terminus fluorophores in modulating ...
Yali Huang, Meihui Yi, Yuchen Qiao, Bing Xu   +3 more
wiley   +1 more source