Results 41 to 50 of about 148,804 (264)

Game Design as STS Research

open access: yesEngaging Science, Technology, and Society, 2017
Game design offers a powerful pedagogical paradigm for engaging students in thinking and researching sociotechnical systems. Using the example of designing a game around fracking, this paper describes how game design grapples with emergent dynamic ...
Joseph Dumit
doaj   +1 more source

Introduction: A Literary Studies/Games Studies Conversation [PDF]

open access: yesGames and Culture, 2019
In this special issue of Games and Culture, we present papers originally delivered at the “Literature and Video Games: Beyond Stereotypes” event co-organized by colleagues from the University of St Andrews, the University of Glasgow, and Abertay University. Instead of gesturing toward a summary and synthesis of the published articles, we invite readers
Margaret-Anne Hutton, Matthew Barr
openaire   +4 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Review: Cooperative Gaming: Diversity in the Games Industry and How to Cultivate Inclusion

open access: yesPress Start, 2022
Review: Alayna Cole and Jessica Zammit’s Cooperative Gaming: Diversity in the Games Industry and How to Cultivate Inclusion. 2020. CRC Press. xv + 95 pp.
Benjamin Hanussek
doaj  

Reconfiguring Daoist Cultivation ina Video Game A Case Study of AMAZING CULTIVATION SIMULATOR

open access: yesJournal for Religion, Film and Media, 2023
With Amazing Cultivation Simulator (GSQ Studio, CN 2019) as a case study, thisarticle analyses how this video game reconfigures the practice of self-cultivation,which has deep roots in religious Daoism, and how it was inspired by online novels ina ...
Yuan, Ye
doaj   +1 more source

Noisy Games: A Study on the Effect of Noise on Game Specifications

open access: yesCoRR, 2023
We consider misinformation games, i.e., multi-agent interactions where the players are misinformed with regards to the game that they play, essentially having an \emph{incorrect} understanding of the game setting, without being aware of their misinformation. In this paper, we introduce and study a new family of misinformation games, called Noisy games,
Constantinos Varsos 0001   +2 more
openaire   +2 more sources

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Urban archetypes applied to the study of cities in historic contemporary fictions. Symbolic urban structures in Age of Empires III and Bioshock Infinite

open access: yesCulture & History Digital Journal, 2020
In “The Idea of a Town: Anthropology of Urban Form” (1976), architecture historian Joseph Rykwert defined six archetypes used in Etruscan rites for the foundation of urban settlements, which continued to be used in Classical Greece and Ancient Rome.
Manuel Sánchez García
doaj   +1 more source

A Behavioral Study of 'Noise' in Coordination Games [PDF]

open access: yesSSRN Electronic Journal, 2014
'Noise' in this study, in the sense of evolutionary game theory, refers to deviations from prevailing behavioral rules. Analyzing data from a laboratory experiment on coordination in networks, we tested 'what kind of noise' is supported by behavioral evidence.
Mäs, Michael, Nax, Heinrich H
openaire   +7 more sources

Translating whole‐genome doubling into precision medicine in cancer

open access: yesMolecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

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