Results 51 to 60 of about 148,804 (264)
Journal of Digital Media & InteractionThis article offers a critical reading of the tensions between two contemporary regimes of game design: on the one side, seamless game design, which aims to smooth out the gaming experience by eliminating any form of rupture; on the other, a set of ...
Brice Roy
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A legend of decolonial critique in play: A horror RPG in speculative worlds
Locus, 2023 How can scholars approach The Secret World Legends (2017), an obscure game rooted in colonialism, as a source of critique that inspires decolonial futures in media broadly?
Luke Hernandez
doaj
Game Stud., 2016 In the last few years there has been an increase in game scholarship conducted in and focussed on areas outside of Western Europe and North America. This scholarship has been recognized and supported by the establishment of regional research networks and regular regional conferences, and has been collected in edited books and journal special issues ...
Liboriussen, Bjarke, Martin, Paul
openaire +2 more sources
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Jeux vidéo : entreprises numériques au croisement du ludique et du narratif
Transatlantica, 2013 This article is concerned with the evolution of the narrative tools implemented by different development studios over the past five decades. Its goal is to raise the question of the evolution of the nature of stories, and of the space devoted to these ...
Rémi Cayatte
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GameSound, Quantitative Games Analysis, and the Digital Humanities
Digital Studies, 2020 This article relates to the 2018 CSDH/SCHN conference proceedings. This paper outlines Michael Iantorno’s and Melissa Mony’s experiences with quantitative game analysis by summarizing the first year of development of the prototype ludomusicological ...
Michael Iantorno
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Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani +6 more
wiley +1 more source
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
FEBS Open Bio, EarlyView.We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli +3 more
wiley +1 more source