Results 71 to 80 of about 13,292,771 (297)
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Alert Hockey: An Endogenous Learning Game [PDF]
, 2007 We describe a video game designed with a subtle and implicit learning mechanism that tracks aggressive and negligent play then uses this data to reduce players abilities and their chance of winning against the computer.
Dobson, Mike +2 more
core +1 more source
How are Games Interpreted? Hermeneutics for Game Studies
Game Studies: the international journal of computer game research, 2022 peerReviewed
openaire +4 more sources
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
The Sacred and the Digital. Critical Depictions of Religions in Digital Games
Religions, 2019 In this editorial, guest editor Frank Bosman introduces the theme of the special issue on critical depictions of religion in video games. He does so by giving a tentative oversight of the academic field of religion and video game research up until ...
Frank G. Bosman
doaj +1 more source
FEBS Open Bio, EarlyView.We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli +3 more
wiley +1 more source
Press Start, 2016 The Editorial Board reflects on the theme of 'conflict', as observed in the work published in this issue, and in the wider world.
Matthew Barr +8 more
doaj
ReS Futurae, 2018 Science-fiction and the imaginary of cosmos bring a fertile framework to video games. Apart the depth of the fictional worlds that it allows to develop, Space void as a narrative and iconographic trope opens a wide variety of issues linked to the ...
Guillaume Baychelier
doaj +1 more source