Results 81 to 90 of about 13,292,771 (297)

Independent Game Development as Craft [PDF]

open access: yes, 2012
This paper celebrates the rise of indie game making as craft in order to explicate the ways in which this activity is both empowering for those involved as well as at risk of reproducing less desirable aspects of the contemporary cultural landscape.
Westecott, Emma
core  

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

open access: yesFEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia   +9 more
wiley   +1 more source

The Relationship Between Perceptions of Video Game Flow and Structure [PDF]

open access: yes, 2008
This inquiry asks whether or not there are preferred structural characteristics of games that are more or less likely to be associated with the experience of psychological flow during gaming.
Gackenbach, Jayne Isabel
core   +1 more source

Monstrous Textuality: Game Fiction between Postmodernism and Structuralism [PDF]

open access: yes, 2011
It has been argued that computer game narratives demonstrate features of what has been called ‘textual monstrosity’--a feature common in the characterization of postmodern narratives (Gib- son, 1996). Is this a mere illusion?
Thabet, Tamer
core   +1 more source

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

open access: yesFEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao   +10 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

open access: yesAging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

The Game FAVR: A Framework for the Analysis of Visual Representation in Video Games [PDF]

open access: yes, 2015
This paper lays out a unified framework of the ergodic animage, the rule-based and interactiondriven part of visual representation in video games. It is the end product of a three-year research project conducted by the INTEGRAE team, and is divided into ...
Arsenault, Dominic   +2 more
core   +1 more source

Regulations relating to game land fur animals, and birds in Alaska /

open access: yes, 1933
Title from cover.Vol. for 1933/34-1939/40 issued as Circular no. 11-17; vols. for 1940/41-1942/43 as Circular AGC-18-20.Separately paged supplements accompany some numbers.Mode of access: Internet.Continued by: Regulations relating to game and fur ...
United States. Alaska Game Commission.
core  

Dimethyl Fumarate, But Not Rituximab, Reduces Serum GFAP Levels and PIRMA in Relapsing–Remitting MS

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) levels are believed to reflect mainly acute and chronic disease processes in multiple sclerosis (MS), respectively. In this study, we investigated whether dimethyl fumarate (DMF) and rituximab (RTX) differentially affect these biomarkers.
F. Shawket   +14 more
wiley   +1 more source

Laws and regulations relating to game land fur-bearing animals and birds in Alaska /

open access: yes, 1926
Title from cover.Also numbered as Circular no. 2-9.Mode of access: Internet.Continued by: Regulations relating to game land fur animals, and birds in Alaska.Continues: Alaska game law and regulations and federal laws relating to game and birds in the ...
United States. Alaska Game Commission.
core  

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