Results 31 to 40 of about 148,804 (264)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Media and CommunicationResearch on women and hostile behaviour in video games has largely focused on women as victims rather than perpetuators of hostile behaviour. In this study, by utilizing discourse analysis, we examine how women’s hostile behaviour is discussed in the ...
Maria Ruotsalainen, Mikko Meriläinen
doaj +1 more source
Sciences du Jeu, 2023 On its website, Sciences du jeu describes itself as an “international and interdisciplinary journal whose mission is to develop and promote French-speaking researc[h] on play”, “to foster dialogue between social sciences and set off debates on this ...
Fanny Barnabé +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Scenarios for Revolution in Sid Meier’s Civilization (1991) and Sid Meier’s Colonization (1994)
Locus, 2023 This article examines the function and representation of the historical concept of ‘revolution’ in Sid Meier’s Civilization and its offshoot Colonization. Revolution is a central concept in both games, although it has a different character and purpose in
Martijn van der Burg
doaj
Communiquer, 2020 Game studies have recently been developed by researchers from different disciplines, each with their own concepts, approaches and methodologies. This article describes how researchers in game studies from the Faculty of Communication of the Université du
Maude Bonenfant +2 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Het spel en de regels. Game studies voor politiek theoretici en cultuurwetenschappers
Locus, 2023 Game studies offers numerous starting points for research by political theorists and cultural scholars. Politics is largely a regulated game, with discussion of the rules of the game always part of the political struggle.
Wim de Jong
doaj
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
, 2022 'Game Studies' is generally used to signify a humanities-based orientation to the study of games, play and related phenomena. This involves the development of conceptual, theoretical and methodological approaches that address the artistic form and aesthetic experience of games as a form of art and entertainment.
openaire +3 more sources