Results 111 to 120 of about 117,473 (191)

Ligand-induced segregation from large cell-surface phosphatases is a critical step in γδ TCR triggering

Cell Reports
Summary: Gamma/delta (γδ) T cells are unconventional lymphocytes that recognize diverse ligands via somatically recombined T cell antigen receptors (γδ TCRs). The molecular mechanism by which ligand recognition initiates γδ TCR signaling, a process known
Fenglei Li, Sobhan Roy, Jacob Niculcea, Keith Gould, Erin J. Adams, P. Anton van der Merwe, Kaushik Choudhuri   +6 more
doaj   +1 more source

Nonclassical MHC‐I Molecules: Emerging Therapeutic Targets in Next‐Generation Immunotherapy

MedComm, Volume 7, Issue 5, May 2026.
Immunotherapies dependent on classical MHC‐I molecules face significant challenges, including extreme polymorphism and frequent downregulation in pathological conditions. This review discusses how nonclassical MHC‐I molecules (HLA‐E, HLA‐F, HLA‐G, CD1, MR1) may potentially circumvent these limitations through restricted genetic diversity, stable ...
Wanlin He, Andrew J. McMichael
wiley   +1 more source

Bortezomib enhances cytotoxicity of ex vivo-expanded gamma delta T cells against acute myeloid leukemia and T-cell acute lymphoblastic leukemia. [PDF]

Cytotherapy, 2021
Story JY, Zoine JT, Burnham RE, Hamilton JAG, Spencer HT, Doering CB, Raikar SS.   +6 more
europepmc   +1 more source

Respiratory Syncytial Virus (RSV): A Comprehensive Overview From Basic Biology to Clinical Prevention and Control

Medicinal Research Reviews, Volume 46, Issue 3, Page 672-712, May 2026.
ABSTRACT Respiratory syncytial virus (RSV) is a common virus that causes respiratory infections, posing a serious threat, particularly to infants, the elderly, and individuals with compromised immune systems. As the leading cause of lower respiratory tract infections (LRTIs) in infants, RSV is responsible for millions of cases worldwide each year.
Jie Shi, Xiya Huang, Chunjun Ye, Yishan Lu, Yanyan Liu, Yuquan Wei, Xiawei Wei   +6 more
wiley   +1 more source

Mapping of γ/δ T cells reveals Vδ2+ T cells resistance to senescenceResearch in context

EBioMedicine, 2019
Background: Immune adaptation with aging is a major of health outcomes. Studies in humans have mainly focus on αβ T cells while γδ T cells have been neglected despite their role in immunosurveillance.
Weili Xu, Gianni Monaco, Eleanor Huijin Wong, Wilson Lek Wen Tan, Hassen Kared, Yannick Simoni, Shu Wen Tan, Wilson Zhi Yong How, Crystal Tze Ying Tan, Bernett Teck Kwong Lee, Daniel Carbajo, Srinivasan K.G., Ivy Chay Huang Low, Esther Wing Hei Mok, Shihui Foo, Josephine Lum, Hong Liang Tey, Wee Ping Tan, Michael Poidinger, Evan Newell, Tze Pin Ng, Roger Foo, Arne N. Akbar, Tamas Fülöp, Anis Larbi   +24 more
doaj   +1 more source

Explicit‐Implicit Material Point Method for Dense Granular Flows With a Novel Regularized µ(I) Model

International Journal for Numerical and Analytical Methods in Geomechanics, Volume 50, Issue 7, Page 3256-3273, May 2026.
ABSTRACT The material point method (MPM) is widely employed to simulate granular flows. Although explicit time integration is favored in most current MPM implementations for its simplicity, it cannot rigorously incorporate the incompressible µ(I)‐rheology, an efficient model ubiquitously adopted in other particle‐based numerical methods. While operator‐
Hang Feng, Zhen‐Yu Yin
wiley   +1 more source

γδ T cells and the PD-1/PD-L1 axis: a love–hate relationship in the tumor microenvironment

Journal of Translational Medicine
Gamma delta (γδ) T cells demonstrate strong cytotoxicity against diverse cancer cell types in an MHC-independent manner, rendering them promising contenders for cancer therapy.
Jian Liu, Min Wu, Yifan Yang, Zixuan Wang, Shan He, Xun Tian, Hui Wang   +6 more
doaj   +1 more source

Influence of Inherited Rifted Margin Architecture on Continental Collision Dynamics

Geochemistry, Geophysics, Geosystems, Volume 27, Issue 5, May 2026.
Abstract Continental collision is a key process in lithospheric evolution, driving mountain building, crustal thickening, and supercontinent assembly. Within the Wilson cycle, collision marks the final stage following rifting, ocean spreading, and subduction.
J. B. Ruh, P. Granado
wiley   +1 more source

From Development to Aging: Dynamic Roles of the Thymic Medulla in T Cell Biology

Immunological Reviews, Volume 339, Issue 1, May 2026.
ABSTRACT The thymic medulla is essential for establishing central tolerance, orchestrating the development of a diverse yet self‐tolerant T cell repertoire, and preventing autoimmunity. This process is primarily mediated through interactions between developing thymocytes and antigen‐presenting cells, including thymic epithelial cells (TECs) and ...
Christina Michalaki, Minahil Sharjeel, Jennifer E. Cowan   +2 more
wiley   +1 more source

Stronger inflammatory/cytotoxic T cell response in women identified by microarray analysis [PDF]

, 2008
Women develop chronic inflammatory autoimmune diseases like lupus more often than men. The mechanisms causing the increased susceptibility are incompletely understood, although estrogen is believed to contribute.
Anura Hewagama, Bruce C. Richardson, Dipak Patel, Faith M. Strickland, Sushma Yarlagadda   +4 more
core   +1 more source