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Expansion of Gammadelta T Cells from Cord Blood: A Therapeutical Possibility [PDF]

Stem Cells International, 2018
Gammadelta (γδ) T cells are found in both blood and tissues and have antiviral and antitumor properties. The frequency of γδ T cells in umbilical cord blood (UCB) is low, and the majority express δ1, in contrast to blood, whereas the main subset is δ2γ9 ...
Sofia Berglund, Ahmed Gaballa, Piamsiri Sawaisorn, Berit Sundberg, Michael Uhlin   +4 more
doaj   +2 more sources

Monitoring circulating gammadelta T cells in cancer patients to optimize gammadelta T cell-based immunotherapy

Frontiers in Immunology, 2014
The success of gammadelta (gd) T cell-based immunotherapy, where the cytotoxic activity of circulating gd T lymphocytes is activated by nitrogen-containing bisphosphonates (n-BP), or possibly by bispecific antibodies or the combination of both, requires ...
Hans-Heinrich eOberg, Christian eKellner, Matthias ePeipp, Susanne eSebens, Sabine eAdam-Klages, Martin eGramatzki, Dieter eKabelitz, Daniela eWesch   +7 more
doaj   +2 more sources

Efficacy of natural killer T and gammadelta T cells in mesothelin-targeted immunotherapy of pancreatic cancer [PDF]

Frontiers in Immunology
Current pancreatic cancer immunotherapy focused on alphabeta (αβ) T cells, either through CD3-engaged bispecific antibodies or CAR-T. Despite their promise, dose-limited toxicity (DLT) remains a challenge in clinical practice. In light of these concerns,
Yuankui Zhu, Yaxi Yang, Linghe Yue, Lei Wan, Xuqian Ma, Qing Yang, Xuan Tian, Yuguan Li, Ke Wang, Shaozhong Wei, Shaozhong Wei, Shaozhong Wei, Dianbao Zuo, Mingqian Feng, Mingqian Feng   +14 more
doaj   +2 more sources

Ageing and latent CMV infection impact on maturation, differentiation and exhaustion profiles of T-cell receptor gammadelta T-cells [PDF]

Scientific Reports, 2017
Ageing is a broad cellular process, largely affecting the immune system, especially T-lymphocytes. Additionally to immunosenescence alone, cytomegalovirus (CMV) infection is thought to have major impacts on T-cell subset composition and exhaustion. These
Martine J. Kallemeijn, Anne Mieke H. Boots, Michèle Y. van der Klift, Elisabeth Brouwer, Wayel H. Abdulahad, Jan A. N. Verhaar, Jacques J. M. van Dongen, Anton W. Langerak   +7 more
doaj   +2 more sources

IL-17-producing gammadelta T cells. [PDF]

Eur J Immunol, 2009
IL-17 is produced not only by CD4(+) alphabeta T cells, but also CD8(+) alphabeta T cells, NKT cells, and gammadelta T cells, plus some non-T cells, including macrophages and neutrophils. The ability of IL-17 to deploy neutrophils to sites of inflammation imparts this cytokine with a key role in diseases of several types.
O'Brien RL, Roark CL, Born WK.
europepmc   +3 more sources

Generation and preclinical characterization of a novel bispecific CD19-TCRgammadelta antibody for the treatment of B cell acute lymphoblastic leukemia [PDF]

Frontiers in Immunology
IntroductionB-cell acute lymphoblastic leukemia (B-ALL) is characterized by the clonal expansion of immature lymphoblastic cells. Treating patients with disease relapse is challenging, especially after allogeneic stem cell transplantation (aSCT ...
Joseph Kauer, Joseph Kauer, Joseph Kauer, Joseph Kauer, Fabian Vogt, Sebastian Hörner, Sebastian Hörner, Sebastian Hörner, Valentin Schmidt, Carsten Müller-Tidow, Simon Raffel, Helmut R. Salih, Helmut R. Salih, Helmut R. Salih, Helmut R. Salih, Gundram Jung, Gundram Jung, Gundram Jung, Gundram Jung, Martin Pflügler, Martin Pflügler, Martin Pflügler, Martin Pflügler   +22 more
doaj   +2 more sources

Photoaffinity antigens for human gammadelta T cells. [PDF]

J Immunol, 2008
Vgamma2Vdelta2 T cells comprise the major subset of peripheral blood gammadelta T cells in humans and expand during infections by recognizing small nonpeptide prenyl pyrophosphates. These molecules include (E)-4-hydroxy-3-methyl-but-2-enyl-pyrophosphate (HMBPP), a microbial isoprenoid intermediate, and isopentenyl pyrophosphate, an endogenous ...
Sarikonda G, Wang H, Puan KJ, Liu XH, Lee HK, Song Y, Distefano MD, Oldfield E, Prestwich GD, Morita CT.   +9 more
europepmc   +3 more sources

gammadelta T cells: the overlooked T-cell subset in demyelinating disease. [PDF]

J Neurosci Res, 2010
gammadelta T cells represent a small subpopulation of T cells expressing a restricted repertoire of T-cell receptors and, unlike alphabeta T cells, function more as cells of the innate immune system. These cells are found in skin and mucosal sites as well as secondary lymphoid tissues and frequently act as first line of defense sentinels.
Wohler JE, Smith SS, Barnum SR.
europepmc   +3 more sources

Regulatory effect of gammadelta T cells on IL-17+ uveitogenic T cells. [PDF]

Invest Ophthalmol Vis Sci, 2010
To characterize the regulatory effect of gammadelta T cells in the activation of IL-17+ uveitogenic T cells.The authors administered the gammadelta TCR-specific antibody GL3 to B6 mice before or after antigen immunization and examined Th1- or Th17-polarized T-cell responses.
Nian H, Shao H, Zhang G, Born WK, O'Brien RL, Kaplan HJ, Sun D.   +6 more
europepmc   +3 more sources

Gammadelta T cells are reduced and rendered unresponsive by hyperglycemia and chronic TNFalpha in mouse models of obesity and metabolic disease. [PDF]

PLoS ONE, 2010
Epithelial cells provide an initial line of defense against damage and pathogens in barrier tissues such as the skin; however this balance is disrupted in obesity and metabolic disease.
Kristen R Taylor, Robyn E Mills, Anne E Costanzo, Julie M Jameson   +3 more
doaj   +1 more source