Results 21 to 30 of about 8,778 (220)

Surfing on the waves of the human γδ T cell ontogenic sea

Immunological Reviews, Volume 315, Issue 1, Page 89-107, May 2023., 2023
Summary While γδ T cells are present virtually in all vertebrates, there is a remarkable lack of conservation of the TRG and TRD loci underlying the generation of the γδ T cell receptor (TCR), which is associated with the generation of species‐specific γδ T cells.
Guillem Sanchez Sanchez, Yohannes Tafesse, Maria Papadopoulou, David Vermijlen   +3 more
wiley   +1 more source

T cell receptor specificity is critical for the development of epidermal gammadelta T cells. [PDF]

, 2001
A particular feature of gammadelta T cell biology is that cells expressing T cell receptor (TCR) using specific Vgamma/Vdelta segments are localized in distinct epithelial sites, e.g., in mouse epidermis nearly all gammadelta T cells express Vgamma3 ...
Beermann, F., Ferrero, I., Held, W., MacDonald, H.R., Wilson, A.   +4 more
core   +1 more source

γδ T cells affect IL-4 production and B-cell tolerance [PDF]

, 2014
γδ T cells can influence specific antibody responses. Here, we report that mice deficient in individual γδ T-cell subsets have altered levels of serum antibodies, including all major subclasses, sometimes regardless of the presence of αβ T cells.
Andrew Getahun, Cohen, Finkelman, Gerber, Greg A. Kirchenbaum, Hidaka, Hirose, Hua Huang, Izui, John C. Cambier, Koichi Ikuta, Kubo, Lawrence J. Wysocki, M. Kemal Aydintug, Rebecca L. O’Brien, Ryan A. Heiser, Simon R. Carding, Sperling, Sunaga, Tamara L. Casper, Thiago O. Detanico, Willi K. Born, Yafei Huang   +22 more
core   +1 more source

Increased cholesterol content in gammadelta (γδ) T lymphocytes differentially regulates their activation. [PDF]

PLoS ONE, 2013
Gammadelta (γδ) T lymphocytes respond quickly upon antigen encounter to produce a cytokine response. In this study, we sought to understand how functions of γδ T cells are differentially regulated compared to αβ T cells.
Hsin-Yuan Cheng, Runpei Wu, Abraham K Gebre, Richard N Hanna, Dan J Smith, John S Parks, Klaus Ley, Catherine C Hedrick   +7 more
doaj   +1 more source

HAUS Augmin‐Like Complex Subunit 1 Influences Tumour Microenvironment and Prognostic Outcomes in Glioma

Journal of Oncology, Volume 2022, Issue 1, 2022., 2022
Background. The expression of HAUS Augmin‐like complex subunit 1 (HAUS1), a protein‐coding gene, is low in normal samples among various cancers with pan‐cancer analysis. The depletion of HAUS1 in cells decreases the G2/M cell compartment and induces apoptosis.
Qi Yao, Xinqi Ge, Zhichao Lu, Jinlong Shi, Jianhong Shen, Jian Chen, Qingbin Cui   +6 more
wiley   +1 more source

Metabolic signaling directs the reciprocal lineage decisions of αβ and γδ T cells [PDF]

, 2018
Wiring metabolic signaling circuits in thymocytes Cell differentiation is often accompanied by metabolic changes. Yang et al. report that generation of double-positive (DP) thymocytes from double-negative (DN) cells coincides with dynamic regulation of ...
Awad, Walid, Blanco, Daniel Bastardo, Chen, Wenan, Chen, Xiang, Cheng, Changde, Chi, Hongbo, Dash, Pradyot, Dhungana, Yogesh, Easton, John, Guo, Xi-Zhi J., Kc, Anil, Neale, Geoffrey, Rosencrance, Celeste, Thomas, Paul G., Yang, Kai   +14 more
core   +1 more source

Highly active microbial phosphoantigen induces rapid yet sustained MEK/Erk- and PI-3K/Akt-mediated signal transduction in anti-tumor human gammadelta T-cells.

PLoS ONE, 2009
BackgroundThe unique responsiveness of Vgamma9Vdelta2 T-cells, the major gammadelta subset of human peripheral blood, to non-peptidic prenyl pyrophosphate antigens constitutes the basis of current gammadelta T-cell-based cancer immunotherapy strategies ...
Daniel V Correia, Francisco d'Orey, Bruno A Cardoso, Telma Lança, Ana R Grosso, Ana deBarros, Leila R Martins, João T Barata, Bruno Silva-Santos   +8 more
doaj   +1 more source

Immune Profile of the Normal Maternal-Fetal Interface in Rhesus Macaques and Its Alteration Following Zika Virus Infection

Frontiers in Immunology, 2021
The maternal decidua is an immunologically complex environment that balances maintenance of immune tolerance to fetal paternal antigens with protection of the fetus against vertical transmission of maternal pathogens.
Matilda J. Moström, Matilda J. Moström, Elizabeth A. Scheef, Lesli M. Sprehe, Dawn Szeltner, Dollnovan Tran, Jon D. Hennebold, Victoria H. J. Roberts, Nicholas J. Maness, Nicholas J. Maness, Marissa Fahlberg, Amitinder Kaur, Amitinder Kaur   +12 more
doaj   +1 more source

[Retracted] CDC20 May Serve as a Potential Biomarker‐Based Risk Score System in Predicting the Prognosis of Patients with Hepatocellular Carcinoma

Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022
Background. The specificity and sensitivity of hepatocellular carcinoma (HCC) diagnostic markers are limited, hindering the early diagnosis and treatment of HCC patients. Therefore, improving prognostic biomarkers for patients with HCC is urgently needed. Methods. HCC‐related datasets were downloaded from the public databases.
Qiliu Peng, Hai Huang, Chunling Zhu, Qingqing Hou, Shangmou Wei, Yi Xiao, Zhi Zhang, Xing Sun, Md Sayed Ali Sheikh   +8 more
wiley   +1 more source

The parasitic worm product ES-62 up-regulates IL-22 production by γδ T cells in the murine model of Collagen-Induced Arthritis [PDF]

, 2014
S-62 is a phosphorylcholine (PC)-containing glycoprotein secreted by the filarial nematode Acanthocheilonema viteae that acts to modulate the host immune response to promote the establishment of chronic helminth infection.
Harnett, Margaret, Harnett, William, Pineda, Miguel Angel   +2 more
core   +1 more source