Results 91 to 100 of about 10,381 (200)

Immune modulation by virus-encoded secreted chemokine binding proteins [PDF]

, 2015
Chemokines are chemoattractant cytokines that mediate the migration of immune cells to sites of infection which play an important role in innate and adaptive immunity. As an immune evasion strategy, large DNA viruses (herpesviruses and poxviruses) encode
Alcamí, Antonio, Heidarieh, Haleh, Hernáez, Bruno   +2 more
core   +1 more source

Humanized Mouse Models of Epstein Barr Virus Infection

Current Protocols, Volume 5, Issue 11, November 2025.
Abstract The oncogenic Epstein Barr virus (EBV) is an exclusively human pathogen with related lymphocryptoviruses (γ1‐herpesviruses) only present in monkeys. Therefore, experimentation with EBV infection in a small animal model requires reconstitution or adoptive transfer of human lymphocyte populations, primarily EBV's main host cell, the human B cell.
Saskia Gertrud von Boxberg, Kristin Gehrmann, Svenja Luisa Nopper, Lucas Romann, Svenja Kösegi, Christian Münz   +5 more
wiley   +1 more source

Animal Models for Gammaherpesvirus Infections: Recent Development in the Analysis of Virus-Induced Pathogenesis

Pathogens, 2020
Epstein−Barr virus (EBV) is involved in the pathogenesis of various lymphomas and carcinomas, whereas Kaposi’s sarcoma-associated herpesvirus (KSHV) participates in the pathogenesis of endothelial sarcoma and lymphomas.
Shigeyoshi Fujiwara, Hiroyuki Nakamura
doaj   +1 more source

Pixelated pathologies: Camera trapping as a tool for monitoring wildlife health

Journal of Applied Ecology, Volume 62, Issue 11, Page 2894-2913, November 2025.
Given the increasing emergence of diseases, some with conservation and public health implications, improving and expanding wildlife health surveillance strategies is imperative. Camera trapping is particularly relevant for detecting new outbreaks, monitoring high‐risk zones and evaluating risk mitigation measures. Abstract Camera trapping has become an
Patricia Barroso, Pablo Palencia
wiley   +1 more source

Gamma Interferon Blocks Gammaherpesvirus Reactivation from Latency [PDF]

Journal of Virology, 2006
ABSTRACTEstablishment of latent infection and reactivation from latency are critical aspects of herpesvirus infection and pathogenesis. Interfering with either of these steps in the herpesvirus life cycle may offer a novel strategy for controlling herpesvirus infection and associated disease pathogenesis. Prior studies show that mice deficient in gamma
Ashley L, Steed, Erik S, Barton, Scott A, Tibbetts, Daniel L, Popkin, Mary L, Lutzke, Rosemary, Rochford, Herbert W, Virgin   +6 more
openaire   +2 more sources

Exacerbated metastatic disease in a mouse mammary tumor model following latent gammaherpesvirus infection [PDF]

, 2012
BACKGROUND: Controversy exists as to the ability of human gammaherpesviruses to cause or exacerbate breast cancer disease in patients. The difficulty in conducting definitive human studies can be overcome by investigating developing breast cancer in a ...
Daniel A Nelson, Kenneth L Bost, Lopamudra Das Roy, Pinku Mukherjee, Vinita S Chauhan   +4 more
core   +1 more source

Vaccination with a Replication-Dead Murine Gammaherpesvirus Lacking Viral Pathogenesis Genes Inhibits WT Virus Infection

Viruses
Gammaherpesviruses are oncogenic pathogens that establish lifelong infections. There are no FDA-approved vaccines against Epstein–Barr virus or Kaposi sarcoma herpesvirus.
Dipanwita Mitra, Darby G. Oldenburg, J. Craig Forrest, Laurie T. Krug   +3 more
doaj   +1 more source

Tertiary Lymphoid Organs at the Center Stage of Skin's Humoral Immunity

Immunological Reviews, Volume 334, Issue 1, September 2025.
ABSTRACT The skin is the outermost organ that serves as the host's live, microbiota‐inhabited physical border, evolved to cope with continuous confrontation by a wide variety of environmental elements. This dynamic borderline is prone to injury and damage.
Inta Gribonika
wiley   +1 more source

A replication-deficient gammaherpesvirus vaccine protects mice from lytic disease and reduces latency establishment

npj Vaccines
Gammaherpesviruses are oncogenic viruses that establish lifelong infections and are significant causes of morbidity and mortality. Vaccine strategies to limit gammaherpesvirus infection and disease are in development, but there are no FDA-approved ...
Wesley A. Bland, Dipanwita Mitra, Shana Owens, Kyle McEvoy, Chad H. Hogan, Luciarita Boccuzzi, Varvara Kirillov, Thomas J. Meyer, Camille Khairallah, Brian S. Sheridan, J. Craig Forrest, Laurie T. Krug   +11 more
doaj   +1 more source

Novel Cereblon‐Binding Immunomodulators Have Increased Potency Against Gammaherpesvirus‐ Associated Lymphomas In Vitro

Journal of Medical Virology, Volume 97, Issue 8, August 2025.
ABSTRACT Primary effusion lymphoma (PEL), which is caused by Kaposi sarcoma herpesvirus (KSHV), and Burkitt lymphoma (BL), a subset of which are associated with Epstein‐Barr virus (EBV), are aggressive non‐Hodgkin's lymphomas. Both have relatively poor survival compared to other lymphomas. Cereblon‐binding immunomodulators (CBIs), such as pomalidomide (
Prabha Shrestha, Emma N. Treco, David A. Davis, Robert Yarchoan   +3 more
wiley   +1 more source