Anti-ganglioside M1 autoantibodies in Egyptian children with autism: a cross-sectional comparative study [PDF]
Middle East Current Psychiatry, 2022 Background Autism may be one of the pediatric autoimmune neuropsychiatric disorders, and several studies investigated the frequency of serum anti-ganglioside M1 autoantibodies in children with autism, as possible indicators of autoimmunity to the brain ...
Reham Mohammad Raafat Hamed +3 more
doaj +2 more sources
More severe manifestations and poorer short-term prognosis of ganglioside-associated Guillain-Barré syndrome in Northeast China. [PDF]
PLoS ONE, 2014 Ganglioside as a neurotrophic drug has been hitherto widely used in China, although Guillain-Barré syndrome (GBS) following intravenous ganglioside treatment was reported in Europe several decades ago.
Xiujuan Wu +11 more
doaj +5 more sources
Dietary Ganglioside Reduces Proinflammatory Signaling in the Intestine
Journal of Nutrition and Metabolism, 2012 Gangliosides are integral to the structure and function of cell membranes. Ganglioside composition of the intestinal brush border and apical surface of the colon influences numerous cell processes including microbial attachment, cell division ...
John Janez Miklavcic +4 more
doaj +2 more sources
Journal of Neuroinflammation, 2011 Background Autoimmunity to the central nervous system (CNS) may play a pathogenic role in a subgroup of patients with autism. This study aimed to investigate the frequency of serum anti-ganglioside M1 auto-antibodies, as indicators of the presence of ...
AL-ayadhi Laila Y, Mostafa Gehan A
doaj +2 more sources
Predicting GD2 expression across cancer types by the integration of pathway topology and transcriptome data [PDF]
Frontiers in BioinformaticsBackgroundThe disialoganglioside GD2 is a key cancer therapy target due to its overexpression in several cancers and limited presence in normal tissues. However, experimental assessment is technically challenging and not routinely available. We developed
Arsenij Ustjanzew +16 more
doaj +2 more sources
Ganglioside lipidomics of CNS myelination using direct infusion shotgun mass spectrometry
iScience, 2022 Summary: Gangliosides are present and concentrated in axons and implicated in axon-myelin interactions, but how ganglioside composition changes during myelin formation is not known.
Martina Arends +12 more
doaj +1 more source
Sialidase NEU3 action on GM1 ganglioside is neuroprotective in GM1 gangliosidosis
Journal of Lipid Research, 2023 GM1 gangliosidosis is a neurodegenerative disorder caused by mutations in the GLB1 gene, which encodes lysosomal β-galactosidase. The enzyme deficiency blocks GM1 ganglioside catabolism, leading to accumulation of GM1 ganglioside and asialo-GM1 ...
Maria L. Allende +10 more
doaj +1 more source
Host factors determine anti-GM1 response following oral challenge of chickens with Guillain-Barré syndrome derived Campylobacter jejuni strain GB11. [PDF]
PLoS ONE, 2010 BackgroundAnti-ganglioside antibodies with a pathogenic potential are present in C. jejuni-associated Guillain-Barré syndrome (GBS) patients and are probably induced by molecular mimicry.
C Wim Ang +7 more
doaj +1 more source
Simultaneous measurements of auto-immune and infectious disease specific antibodies using a high throughput multiplexing tool. [PDF]
PLoS ONE, 2012 Considering importance of ganglioside antibodies as biomarkers in various immune-mediated neuropathies and neurological disorders, we developed a high throughput multiplexing tool for the assessment of gangliosides-specific antibodies based on Biolpex ...
Atul Asati +2 more
doaj +1 more source
International Journal of Molecular Sciences, 2020 Many species of ganglioside GM1, differing for the sialic acid and ceramide content, have been characterized and their physico-chemical properties have been studied in detail since 1963.
E. Chiricozzi +5 more
semanticscholar +1 more source