Results 91 to 100 of about 79,768 (305)

Uncovering the Complexity of Synucleinopathies: An Ongoing Tale Between Proteins and Lipids

Movement Disorders, EarlyView.
Abstract Neurodegenerative diseases are pathological states characterized by progressive alterations in brain homeostasis during aging. Synucleinopathies, including Parkinson's disease and dementia with Lewy bodies, are defined neuropathologically by the accumulation of inclusions known as Lewy bodies and Lewy neurites.
Manuel Flores‐León, Tiago F. Outeiro
wiley   +1 more source

Ablation of Neuronal Ceramide Synthase 1 in Mice Decreases Ganglioside Levels and Expression of Myelin-associated Glycoprotein in Oligodendrocytes*

Journal of Biological Chemistry, 2012
Background: Ceramide synthase 1 catalyzes the synthesis of C18 ceramide and is mainly expressed in neurons of the brain. Results: Ablation of ceramide synthase 1 decreases ganglioside levels and expression of oligodendrocytic myelin-associated ...
Christina Ginkel, D. Hartmann, Katharina vom Dorp, A. Zlomuzica, Hany Farwanah, M. Eckhardt, R. Sandhoff, Joachim Degen, M. Rabionet, E. Dere, P. Dörmann, K. Sandhoff, K. Willecke   +12 more
semanticscholar   +1 more source

Exosomes promote pre-metastatic niche formation in ovarian cancer. [PDF]

, 2019
Ovarian cancer is one of the most common gynecological malignancies. Upon initial diagnosis, the majority of patients present with widespread metastatic growth within the peritoneal cavity. This metastatic growth occurs in stages, with the formation of a
Dean, Dylan C, Duan, Zhenfeng, Feng, Wenlong, Hornicek, Francis J, Shi, Huirong   +4 more
core   +2 more sources

Human medulloblastoma gangliosides [PDF]

Glycobiology, 1997
To establish a model system for the study of ganglioside metabolism of the human brain tumor, medulloblastoma, we have chemically characterized the gangliosides of the Daoy cell line. These cells contain a high concentration of gangliosides (143 +/- 13 nmol LBSA/10(8) cells). The major species have been structurally confirmed to be GM2 (65.9%), GM3 (13.
F, Chang, R, Li, K, Noon, D, Gage, S, Ladisch   +4 more
openaire   +2 more sources

Enhancing Selective Brain Cancer Therapy: Integrating Nanomedicine and Molecular Dynamics to Target the Cancerous Lipid Composition

Nano Select, EarlyView.
Improving selectivity within therapeutic design is critical to ensure targeted delivery to brain tumors. Targeting the cellular membrane composition distinctive of the blood–brain barrier and brain cancer cells is explored in this review. Nanomedicine can be utilized for precise tumor recognition, and detailed mechanistic interactions of therapeutics ...
Mahnoor Kadri, Dominique de Jong‐Hoogland, Martin B. Ulmschneider   +2 more
wiley   +1 more source

Botulinum Neurotoxin Serotype C Associates with Dual Ganglioside Receptors to Facilitate Cell Entry*

Journal of Biological Chemistry, 2012
Background: How botulinum neurotoxin serotype C (BoNT/C) enters neurons is unclear. Results: BoNT/C utilizes dual gangliosides as host cell receptors. Conclusion: BoNT/C accesses gangliosides on the plasma membrane.
A. Karalewitz, Z. Fu, M. R. Baldwin, Jung‐Ja P. Kim, J. Barbieri   +4 more
semanticscholar   +1 more source

The binding of botulinum neurotoxins to different peripheral neurons [PDF]

, 2017
Botulinum neurotoxins are the most potent toxins known. The double receptor binding modality represents one of the most significant properties of botulinum neurotoxins and largely accounts for their incredible potency and lethality.
Rossetto, O.
core   +1 more source

Enhancing Lipidomics With High‐Resolution Ion Mobility‐Mass Spectrometry

PROTEOMICS, EarlyView.
ABSTRACT Lipids, indispensable yet structurally intricate biomolecules, serve as critical regulators of cellular function and disease progression. Conventional lipidomics, constrained by limited resolution for isomeric and low‐abundance species, has been transformed by ion mobility‐mass spectrometry (IM‐MS).
Gaoyuan Lu, Shuling Xu, Penghsuan Huang, Lingjun Li   +3 more
wiley   +1 more source

Characterization of GM1 ganglioside by direct inlet chemical ionization mass spectrometry.

Journal of Lipid Research, 1982
Intact permethylated and permethylated-reduced (LiAlH4) derivatives of GM1 ganglioside were analyzed by direct inlet ammonia chemical ionization (CI) mass spectrometry. In addition, the trimethylsilylated derivative of the permethylated-reduced sample of
T Ariga, R K Yu, M Suzuki, S Ando, T Miyatake   +4 more
doaj   +1 more source

Malignant phyllodes tumors display mesenchymal stem cell features and aldehyde dehydrogenase/disialoganglioside identify their tumor stem cells. [PDF]

, 2014
IntroductionAlthough breast phyllodes tumors are rare, there is no effective therapy other than surgery. Little is known about their tumor biology.
Chou, Fen-Pi, Huang, Chiun-Sheng, Hung, Jung-Tung, Liao, Guo-Shiou, Lien, Huang-Chun, Lin, Jin-Jin, Lin, Ruey-Jen, Yeh, Kun-Tu, Yu, Alice L, Yu, John   +9 more
core   +3 more sources