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Food Frontiers, Volume 6, Issue 6, Page 3108-3121, November 2025.Lipid metabolism disorders (LMDs) can cause many metabolic diseases and seriously threaten human health. It is necessary to develop safe drugs for long‐term use in LMDs patients. Ganoderma lucidum (G.
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[Biosynthesis of ganoderic acid and its derivatives].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medicaGanoderic acid is a class of lanostane-type triterpenoids found in Ganoderma species, and is one of the most important pharmacologically active components in G. lucidum, exhibiting antioxidant, anti-neuropsychiatric, anti-tumor, and immune-enhancing properties. The content of ganoderic acid in G.
Hongyan Song +5 more
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Ganoderic acid B attenuates LPS-induced lung injury
International Immunopharmacology, 2020Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a serious respiratory disease, the mechanism is unclear. This paper revealed the mechanism of ganoderic acid B (BB) on lipopolysaccharide-induced pneumonia in mice. Pneumonia model was induced by LPS in mice and A549 cells. Lung dry/wet weight (W/D) and myeloperoxidase (MPO) activity
Jiang, Shi +7 more
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Ganoderic acid improves 5-fluorouracil-induced cognitive dysfunction in mice
Food & Function, 2021Ganoderic acid, isolated from Ganoderma lucidum, significantly ameliorated 5-FU induced cognitive impairment via preventing mitochondrial impairment and enhancing neuronal survival and growth.
Abudumijiti Abulizi +12 more
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Mitochondrial pyruvate carrier influences ganoderic acid biosynthesis in Ganoderma lucidum
Applied Microbiology and Biotechnology, 2023Mitochondrial pyruvate carriers (MPCs), located in the inner membrane of mitochondria, are essential carriers for pyruvate to enter mitochondria. MPCs regulate a wide range of intracellular metabolic processes, such as glycolysis, the tricarboxylic acid cycle (TCA cycle), fatty acid metabolism, and amino acid metabolism.
Juhong Chen +8 more
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Biotechnological production and application of ganoderic acids
Applied Microbiology and Biotechnology, 2010Ganoderic acids (GAs), a kind of highly oxygenated lanostane-type triterpenoids, are important bioactive constituents of the famous medicinal mushroom Ganoderma lucidum. They have received wide attention in recent years due to extraordinarily pharmacological functions. Submerged fermentation of G.
Jun-Wei, Xu +2 more
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Ganoderic acid DM: Anti-androgenic osteoclastogenesis inhibitor
Bioorganic & Medicinal Chemistry Letters, 2009Prostate cancer is the most common cancer in men in Western countries, with a high incidence of bone metastasis. Ganoderic acid DM, with 5alpha-reductase inhibitory and androgen receptor (AR) binding activity, isolated from the ethanol extracts of Ganoderma lucidum, can inhibit prostate cancer cell growth and block osteoclastogenesis.
Jie, Liu +5 more
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Ganoderic Acid and Lucidenic Acid (Triterpenoid)
2014Ganoderma species is known as a functional mushroom used in many Asian countries. Triterpenoids, ganoderic acids, and lucidenic acids have been isolated from Ganoderma species (Ganodermataceae family), such as Ganoderma lucidum. Triterpenoids have been investigated for their biological activities, including antibacterial, antiviral, antitumor ...
Chin-Lin, Hsu, Gow-Chin, Yen
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Ganoderic Acid A Inhibits Bleomycin-Induced Lung Fibrosis in Mice
Pharmacology, 2020<b><i>Background:</i></b> To study the protective effects of ganoderic acid A (GAA) on bleomycin (BLM)-induced pulmonary fibrosis. <b><i>Methods:</i></b> ICR mice were intratracheally instilled with BLM to induce pulmonary fibrosis on day 0.
Gaoyan, Wen +4 more
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