Results 181 to 190 of about 10,827 (210)

Ganoderic acid, lanostanoid triterpene: a key player in apoptosis

Investigational New Drugs, 2017
Cancer is a multifactorial disease, causing behavioral and metabolic alterations, leading to uncontrolled cell proliferation with collateral weakening of immune system. Crucial balance between cell proliferation and cell death determines the fate of a cell, which might progress towards survival or apoptosis.
Balraj Singh, Gill, , Navgeet, Richa, Mehra, Vicky, Kumar, Sanjeev, Kumar   +4 more
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Protective effect of Ganoderic acid A on adjuvant-induced arthritis

Immunology Letters, 2020
The purpose of the experiment was to explore the effect of Ganoderic acid A (GAA) on adjuvant-induced arthritis in rats. In this study, the rat model of collagen-induced rheumatoid arthritis (CIA) was established with type II collagen plus Freund's complete adjuvant. Arthritis index, joint pathology, toe swelling, hemorheology, synovial cell apoptosis,
Tao, Cao, Chuanfeng, Tang, Lezhen, Xue, Mingzhu, Cui, Dan, Wang   +4 more
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ChemInform Abstract: Ganoderic Acid DM: Antiandrogenic Osteoclastogenesis Inhibitor.

ChemInform, 2009
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Jie Liu, Jun Shiono, Kuniyoshi Shimizu, Akiko Kukita, Toshio Kukita, Ryuichiro Kondo   +5 more
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Ganoderic acid A against cyclophosphamide‐induced hepatic toxicity in mice

Journal of Biochemical and Molecular Toxicology, 2018
AbstractThis study clarified the protective effect of ganoderic acid A (GAA) on cyclophosphamide (CP)‐induced hepatotoxicity in mice. Hepatic injury mice were induced by a single intraperitoneal injection of CP (200 mg/kg). The results showed that the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum and liver of ...
Xu Lixin, Yan Lijun, Huang Songping
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Preparative isolation of ganoderic acid S, ganoderic acid T and ganoderol B from Ganoderma lucidum mycelia by high‐speed counter‐current chromatography

Biomedical Chromatography, 2018
AbstractGanoderic acid S, ganoderic acid T and ganoderal B are the main bioactive triterpenes of Ganoderma lucidum. In this study, mycelia of G. lucidum were obtained by two‐stage fermentation and then extracted by ethanol and petroleum ether sequentially to obtain crude triterpenes. The crude sample was further purified by recycling high‐speed counter‐
Na Feng, Yutian Wei, Jie Feng, Qingjiu Tang, Zhong Zhang, Jingsong Zhang, Wei Han   +6 more
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[Pharmacokinetics of ganoderic acids].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2019
Ganoderic acid(GA) is one of main bioactive components produced by Ganoderma lucidum,which a traditional Chinese herbal medicine and a kind of tracyclic triterpene lanosterol derivatives with highly oxidized structure. It has a variety of important pharmacological activities,such as anticancer,immunoregulation,anti-oxidation,anti-diabetes and anti-HIV.
Fei-Fei, Zhang, Ru-Ming, Liu
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Antioxidant potential of ganoderic acid in Notch-1 protein in neuroblastoma

Molecular and Cellular Biochemistry, 2018
Neuroblastoma is a childhood tumor arising from developing a sympathetic nervous system and causes around 10% of pediatric tumors. Despite advancement in the use of sophisticated techniques in molecular biology, neuroblastoma patient's survivability rate is very less.
Balraj Singh, Gill, , Navgeet, Sanjeev, Kumar   +2 more
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Regulation of osteoclastogenesis by ganoderic acid DM isolated from Ganoderma lucidum

European Journal of Pharmacology, 2009
The preventative effects of the ethanol extracts of Ganoderma lucidum against the ovariectomized (Ovx)-induced deterioration of bone density in 11-week-old female Sprague Dawley (SD) rats were investigated. The results showed that the G. lucidum-treated Ovx rats showed improved bone density compared with the Ovx rats.
Ichiko, Miyamoto, Jie, Liu, Kuniyoshi, Shimizu, Masao, Sato, Akiko, Kukita, Toshio, Kukita, Ryuichiro, Kondo   +6 more
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Ethylene promotes mycelial growth and ganoderic acid biosynthesis in Ganoderma lucidum

Biotechnology Letters, 2016
To investigate the effects of ethylene, in the form of ethephon (2-chloroethylphosphonic acid), on mycelial growth and ganoderic acid (GA) accumulation in the higher basidiomycete Ganoderma lucidum.Treatment with both 10 and 15 mM ethephon enhanced the growth of G. lucidum on solid CYM plates and in CYM liquid medium.
Guang, Zhang, Ang, Ren, Fengli, Wu, Hanshou, Yu, Liang, Shi, Mingwen, Zhao   +5 more
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Extraction and isolation of ganoderic acid Σ from Ganoderma lucidum

Tetrahedron Letters, 2016
Abstract A new lanostane triterpene was extracted from Ganoderma lucidum using cellulose-dissolving ionic liquids. The structure of the isolated compound was elucidated by spectroscopic analysis, including NMR, MS, and a modified Mosher’s method. The newly isolated lanostane natural product was named ganoderic acid Σ .
Chihiro Murata, Quang Thuong Tran, Shingo Onda, Toyonobu Usuki   +3 more
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