Results 171 to 180 of about 701,063 (234)

Ganoderic acid A improves osteoarthritis by regulating RANKL/OPG ratio

Chemical Biology & Drug Design, 2022
Ganoderma mushrooms have been used to treat rheumatoid arthritis (RA) in East Asia. Whether Ganoderic acid A (GAA), the natural product extracted from Ganoderma, could be utilized to alleviate osteoarthritis (OA) is investigated in this study ...
Wenxiao Wu, K. Song, Guangdong Chen, Ning Liu, Tongjun Cao   +4 more
semanticscholar   +3 more sources

Ganoderic Acid A: A Potential Natural Neuroprotective Agent for Neurological Disorders: A Review.

International Journal of Medicinal Mushrooms
Ganoderic acid A (GAA) is one of the major triterpenoids in Ganoderma lucidum (GL). Accumulating evidence has indicated that GAA demonstrates multiple pharmacological effects and exhibits treatment potential for various neurological disorders.
Feifei Ma, Jing Wang, Wenming Jiang, Jiahao Luo, Rui Yang, Liying Zhang, Chunchao Han   +6 more
semanticscholar   +3 more sources

A Study on the Effect of Ganoderic Acid A on Nociceptive and Inflammatory Mice Models

Pharmacognosy Magazine
Background Inflammatory illnesses and severe tissue injuries are frequently accompanied by pain. A widespread global health issue that has a significant negative impact on people’s quality of life everywhere is inflammation and the pain it causes ...
Haizhou Yu, Qiaojian Tao, Xianjing Zeng, Jinfeng Zhou   +3 more
semanticscholar   +2 more sources

Ganoderic acid A alleviate psoriasis by inhibiting GSDMD-mediated pyroptosis.

Tissue and Cell
Chenggen Xiao, Junchen Chen, Xingchen Zhou, Hong Liu   +3 more
semanticscholar   +2 more sources

Protective effect of Ganoderic acid A on adjuvant-induced arthritis

Immunology Letters, 2020
The purpose of the experiment was to explore the effect of Ganoderic acid A (GAA) on adjuvant-induced arthritis in rats. In this study, the rat model of collagen-induced rheumatoid arthritis (CIA) was established with type II collagen plus Freund's complete adjuvant. Arthritis index, joint pathology, toe swelling, hemorheology, synovial cell apoptosis,
Tao, Cao, Chuanfeng, Tang, Lezhen, Xue, Mingzhu, Cui, Dan, Wang   +4 more
openaire   +2 more sources

Ganoderic Acid A Inhibits Bleomycin-Induced Lung Fibrosis in Mice

Pharmacology, 2020
<b><i>Background:</i></b> To study the protective effects of ganoderic acid A (GAA) on bleomycin (BLM)-induced pulmonary fibrosis. <b><i>Methods:</i></b> ICR mice were intratracheally instilled with BLM to induce pulmonary fibrosis on day 0.
Gaoyan, Wen, Tian, Li, Hua, He, Xianmei, Zhou, Jia, Zhu   +4 more
openaire   +2 more sources

Ganoderic acid A: an in-depth review of pharmacological effects and molecular docking analysis.

Journal of Ethnopharmacology
Ganoderic acid A (GAA, C30H44O7) is one of the most abundant and active components of Ganoderic acids (GAs). GAs are highly oxidized tetracyclic triterpenoid compounds mainly derived from Ganoderma lucidum (Curtis) P. Karst (Chinese: ). GAA is primarily isolated from the fruiting body of Ganoderma lucidum.
Qi Sui, Chengkai Zhu, Sha Shi, Jiaqi Xu, Jingnan Zhang, Ao Wang, Peng Chen, Guang Liang, Yi Zhang   +8 more
semanticscholar   +3 more sources

Ganoderic acid A from Ganoderma lucidum protects against alcoholic liver injury through ameliorating the lipid metabolism and modulating the intestinal microbial composition.

Food & Function, 2022
Alcoholic liver injury is mainly caused by long-term excessive alcohol consumption and has become a global public threat to human health. It is well known that Ganoderma lucidum has excellent beneficial effects on liver function and lipid metabolism. The
Xu-Cong Lv, Qi Wu, Yingjia Cao, Yi-Chen Lin, Wei-ling Guo, P. Rao, Yan-Yan Zhang, Youting Chen, Lian-zhong Ai, Li Ni   +9 more
semanticscholar   +1 more source

A new ganoderic acid from Ganoderma lucidum mycelia

Journal of Asian Natural Products Research, 2010
A new ganoderic acid (GA), 7-O-ethyl ganoderic acid O (GA-O) (1), together with two known compounds, GA-T (2) and GA-Me (3), was isolated and purified from fermented mycelia of Ganoderma lucidum. The structure of the new triterpenoid was elucidated on the basis of the interpretation of extensive spectroscopic data (HR-MS, IR, UV, 1D and 2D NMR) as 3 ...
Jia-Le, Wang, Ying-Bo, Li, Ru-Ming, Liu, Jian-Jiang, Zhong   +3 more
openaire   +2 more sources

Ganoderic acid, lanostanoid triterpene: a key player in apoptosis

Investigational New Drugs, 2017
Cancer is a multifactorial disease, causing behavioral and metabolic alterations, leading to uncontrolled cell proliferation with collateral weakening of immune system. Crucial balance between cell proliferation and cell death determines the fate of a cell, which might progress towards survival or apoptosis.
Balraj Singh, Gill, , Navgeet, Richa, Mehra, Vicky, Kumar, Sanjeev, Kumar   +4 more
openaire   +2 more sources