ATP deficiency triggers ganoderic acids accumulation via fatty acid β-oxidation pathway in Ganoderma lucidum [PDF]
Microbial Cell FactoriesBackground Ganoderic acids (GAs), recognized as significant triterpenoid bioactive components in Ganoderma lucidum, exhibit a broad spectrum of pharmacological activities, including immunomodulation, anti-cancer, and anti-aging properties.
Weidong Liu +7 more
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A methyltransferase LaeA regulates ganoderic acid biosynthesis in Ganoderma lingzhi
Frontiers in Microbiology, 2022 The methyltransferase LaeA is a global regulator involved in the biosynthesis of secondary metabolites by ascomycete fungi. However, little is known of its regulatory role in basidiomycete fungi.
Qin Luo, Na Li, Jun-Wei Xu
doaj +3 more sources
Application of Electronic tongue and HPLC in rapid determination of functional triterpenes and origins of Ganoderma lucidum [PDF]
Frontiers in NutritionIntroductionGanoderma lucidum is one well known functional food resource. The triterpenes, such as Ganoderic acid A and Ganoderic acid D, as well as the sensory characteristics could reflect the quality of G. lucidum.MethodsIn order to find rapid methods
Jing Tian +16 more
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Pharmacokinetics of ganoderic acids a and f after oral administration of ling zhi preparation in healthy male volunteers. [PDF]
Evid Based Complement Alternat Med, 2012 The objectives of this paper were to evaluate the pharmacokinetics of ganoderic acids A and F after a single oral dose of the water extract of MG2-strain Ling Zhi (MG2FB-WE) and to assess the influence of food on the pharmacokinetics in 12 healthy male ...
Teekachunhatean S +5 more
europepmc +5 more sources
Decoding and reprogramming of the biosynthetic networks of mushroom-derived bioactive type II ganoderic acids in yeast [PDF]
Cell DiscoveryMushroom’s specialized secondary metabolites possess important pharmacological activities, but their biosynthetic pathway elucidation is extremely challenging, not to mention reprogramming of their biosynthetic networks to target metabolites.
Qin Wang +12 more
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Hydrogen sulfide maintains mitochondrial homeostasis and regulates ganoderic acids biosynthesis by SQR under heat stress in Ganoderma lucidum [PDF]
Redox BiologyHydrogen sulfide (H2S) has recently been recognized as an important gaseous transmitter with multiple physiological effects in various species. Previous studies have shown that H2S alleviated heat-induced ganoderic acids (GAs) biosynthesis, an important ...
Jiaolei Shangguan +9 more
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Unveiling triterpenoid superiority in a newly developed Ganoderma lucidum variety through untargeted metabolomics approach [PDF]
Frontiers in NutritionThe fruiting bodies of Ganoderma lucidum are renowned for their therapeutic properties, primarily due to their triterpenoid content. Variability in G. lucidum strains may influence the composition and abundance of triterpenoids.
Zhibin Pan +5 more
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Ganoderic acid B’s influence towards the therapeutic window of trifluoperazine (TFP) [PDF]
African Health Sciences, 2015 Background: Ganoderic acid B is an important bioactive ingredient isolated from Ganoderma lucidum, and exhibits various pharmacological activities.Aims: To investigate the influence of Ganoderic acid B towards the therapeutic window of trifluoperazine ...
Guo, J, Liu, T, Liu, X, Ni, C
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Can Ganoderma Triterpenoids Exert Immunogenic Cell Death in Human Cancer Cells? A Systematic Review and Protein Network Analysis [PDF]
PharmaceuticalsBackground: Permanent cancer resolution requires a complete immunological response with generation of memory against malignant cells. Immunogenic cell death (ICD) achieves this by coupling cell death with the emission of damage-associated molecular ...
Jorge C. Ramírez-Gutiérrez +4 more
doaj +2 more sources
Current Techniques for the Cultivation of Ganoderma lucidum for the Production of Biomass, Ganoderic Acid and Polysaccharides [PDF]
Food Technology and Biotechnology, 2003 Ganoderma lucidum is a medicinal mushroom that has been used in the Orient for more than 2000 years. Due to the long time required for basidiocarp formation, attention has recently been given to the use of submerged fermentation for the production of ...
Ricardo Wagner +4 more
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