Results 21 to 30 of about 6,819 (187)

Ganoderic Acids Prevent Renal Ischemia Reperfusion Injury by Inhibiting Inflammation and Apoptosis. [PDF]

Int J Mol Sci, 2021
Renal ischemia reperfusion injury (RIRI) is one of the main causes of acute kidney injury (AKI), which can lead to acute renal failure. The development of RIRI is so complicated that it involves many factors such as inflammatory response, oxidative stress and cell apoptosis.
Shao G, He J, Meng J, Ma A, Geng X, Zhang S, Qiu Z, Lin D, Li M, Zhou H, Lin S, Yang B.   +11 more
europepmc   +4 more sources

Glycosylation of Ganoderic Acid G by Bacillus Glycosyltransferases [PDF]

International Journal of Molecular Sciences, 2021
Ganoderma lucidum is a medicinal fungus abundant in triterpenoids, its primary bioactive components. Although numerous Ganoderma triterpenoids have already been identified, rare Ganoderma triterpenoid saponins were recently discovered. To create novel Ganoderma saponins, ganoderic acid G (GAG) was selected for biotransformation using four Bacillus ...
Jiumn-Yih Wu, Hsiou-Yu Ding, Tzi-Yuan Wang, Yun-Rong Zhang, Te-Sheng Chang   +4 more
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Ganoderic Acid A Alleviates OVA-Induced Asthma in Mice [PDF]

Inflammation, 2021
AbstractThe aim of this study is to investigate the effects of ganoderic acid A (GAA) on OVA-induced asthma in mice. Mouse asthma model was established by ovalbumin (OVA) in vitro. Diff-Quik staining was used to observe the total numbers of cells and the number of classification cells in each group, and HE staining was used to observe lung inflammation
Xinhua Lu, Chenyang Xu, Rui Yang, Guojun Zhang   +3 more
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A Review on the Sources, Structures, and Pharmacological Activities of Lucidenic Acids

Molecules, 2023
Ganoderma lucidum has long been used as a multi-purpose plant and functional food. The pharmacological properties of G. lucidum are primarily attributed to its polysaccharides and triterpenoids.
Chengwen Zheng, Panthakarn Rangsinth, Polly H. T. Shiu, Wen Wang, Renkai Li, Jingjing Li, Yiu-Wa Kwan, George P. H. Leung   +7 more
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Improved ganoderic acids production in Ganoderma lucidum by wood decaying components. [PDF]

Sci Rep, 2017
AbstractGanoderma lucidumis a legendary Traditional Chinese Medicine (TCM) over a few thousands of years and one kind of its major active components are Ganoderic acids (GAs). GAs are largely produced in the mushroom primordium and fruiting body but much less in mycelium stage. However, little is known on the underlying regulatory mechanism.
Hu Y, Ahmed S, Li J, Luo B, Gao Z, Zhang Q, Li X, Hu X.   +7 more
europepmc   +4 more sources

Pharmacokinetic, Metabolomic, and Stability Assessment of Ganoderic Acid H Based Triterpenoid Enriched Fraction of Ganoderma lucidum P. Karst

Metabolites, 2022
Ganoderma lucidum P. karst is an edible fungus that is used in traditional medicine and contains triterpenoids as the major phytoconstituents. Ganoderic acids are the most abundant triterpenoids that showed pharmacological activity.
Mohd Hafizur Rehman Ansari, Washim Khan, Rabea Parveen, Sadia Saher, Sayeed Ahmad   +4 more
doaj   +1 more source

Antiproliferative Activity of Mycelium vs. Fruiting Body: Ganoderma subincrustatum and G. weberianum from Sonora, Mexico

Microbiology Research, 2023
The genus Ganoderma has been little studied in arid areas worldwide. Ganoderma subincrustatum and Ganoderma weberianum strains were obtained from the Sonoran Desert, Sonora, Mexico. Ganoderma spp.
Damian López-Peña, Heriberto Torres-Moreno, Max Vidal-Gutiérrez, Ramón Enrique Robles-Zepeda, Aldo Gutiérrez, Martín Esqueda   +5 more
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Ganoderic Acid A Metabolites and Their Metabolic Kinetics [PDF]

Frontiers in Pharmacology, 2017
Ganoderic acid A (GAA), a representative active triterpenoid from Ganoderma lucidum, has been reported to exhibit antinociceptive, antioxidative, cytotoxic, hepatoprotective and anticancer activities. The present study aims (1) to identify GAA metabolites, in vivo by analyzing the bile, plasma and urine after intravenous administration to rats (20 mg ...
Cao, Fang-Rui, Feng, Li, Ye, Lin-Hu, Wang, Li-Sha, Xiao, Bing-Xin, Tao, Xue, Chang, Qi   +6 more
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Biotransformation of Ganoderic Acid A to 3-O-Acetyl Ganoderic Acid A by Soil-isolated Streptomyces sp. [PDF]

Fermentation, 2018
The medicinal fungus Ganoderma lucidum contains many bioactive triterpenoids, ganoderic acid A (GAA) being one of the major ones. The present study explored the microbial biotransformation of GAA, isolating 283 strains of soil actinomycetes and determining their abilities to biotransform GAA with ultra-performance liquid chromatography analysis.
Te-Sheng Chang, Horng-Huey Ko, Tzi-Yuan Wang, Chun-Hsien Lee, Jiumn-Yih Wu   +4 more
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Potential Active Compounds of <i>Ganoderma lucidum</i> and Their Anticancer Effects: A Comprehensive Review. [PDF]

Food Sci Nutr
This paper systematically discusses various active compounds within Ganoderma lucidum and their application in the treatment of tumor diseases. ABSTRACT The incidence and mortality rates of cancer patients continue to rise. Although many physical and chemical therapies, such as targeted tumor treatments, are effective against cancer, they are often ...
Liu Y, Ren S, Sang Q, Cheng X, Bi Y.
europepmc   +2 more sources