Results 111 to 120 of about 393,906 (290)

Quantum Spin Hall and Quantum Anomalous Hall States Realized in Junction Quantum Wells

, 2014
Both quantum spin Hall and quantum anomalous Hall states are novel states of quantum matter with promising applications. We propose junction quantum wells comprising II-VI, III-V or IV semiconductors as a large class of new materials realizing the ...
Chang, K, Wang, J, Xu, Y, Zhang, HJ, Zhang, SC   +4 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Transport through superconductor/magnetic dot/superconductor structures

, 2001
The coupling of two s-wave superconductors through a small magnetic dot is discussed. Assuming that the dot charging energy is small compared to the superconducting gap, $E_c\ll \Delta$, and that the moment of the dot is classical, we develop a simple ...
Averin, Barash, Barash, Beenakker, Bratus, Bulaevskiĭ, Buzdin, Cron, Cuevas, Cuevas, Fogelström, Fogelström, Furusaki, J.C. Cuevas, Johansson, Klapwijk, Levy Yeyati, Löfwander, M. Andersson, M. Fogelström, Riedel, Ryazanov, Scheer, Scheer, Shiba, Shiba, Tanaka, Tokyyasu, Yip   +28 more
core   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Gap junction-mediated regulation of endothelial cellular stiffness

Scientific Reports, 2017
Endothelial monolayers have shown the ability to signal each other through gap junctions. Gap junction-mediated cell-cell interactions have been implicated in the modulation of endothelial cell functions during vascular inflammation.
Takayuki Okamoto, Eiji Kawamoto, Yoshimi Takagi, Nobuyuki Akita, Tatsuya Hayashi, Eun Jeong Park, Koji Suzuki, Motomu Shimaoka   +7 more
doaj   +1 more source

Coherent Operation of a Gap-tunable Flux Qubit

, 2010
We replace the Josephson junction defining a three-junction flux qubit's properties with a tunable direct current superconducting quantum interference devices (DC-SQUID) in order to tune the qubit gap during the experiment. We observe different gaps as a
Kemp, Alexander, Saito, Shiro, Semba, Kouichi, Zhu, Xiaobo   +3 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Tunneling assisted p-contact free GaN-InGaN green light-emitting diodes

Journal of Information Display
The effects of bottom tunnel junction (TJ) on optoelectronic characteristics of green light-emitting diodes are analyzed numerically. Our proposed LED has enhanced internal quantum efficiency (IQE), radiative recombination rate, and carrier concentration
Jamshad Bashir, Muhammad Usman, Shazma Ali, Laraib Mustafa   +3 more
doaj   +1 more source

Phase diagram of Josephson junction between s and s+- superconductors in dirty limit

, 2012
The s+- state in which order parameter has different signs in different bands is a leading candidate for the superconducting state in the iron based superconductors. We investigate a Josephson junction between s and s+- superconductors within microscopic
Koshelev, A. E.
core   +1 more source