Results 121 to 130 of about 142,570 (302)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Junction (Gap, Tight, Adherens) Pathways Mechanistic Genes.
, 2012 Junction (Gap, Tight, Adherens) Pathways Mechanistic Genes.
Sangeeta Khare (141487) +11 more
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Pannexin channels are not gap junction hemichannels
, 2011 Pannexins, a class of membrane channels, bear significant sequence homology with the invertebrate gap junction proteins, innexins, and more distant similarities in their membrane topologies and pharmacological sensitivities with the gap junction proteins,
Dahl, Gerhard +25 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Role of Gap Junction in Atrial Fibrillation Pathophysiology
Majalah Kardiologi Indonesia, 2013 Initiation of atrial fibrillation (AF) occurred when there is a combination of triggering factors (mainly originated from thoracic veins) and arrhytmogenic substrate, such as : reduction of effective refractory period (ERP), increase in refractory ...
doaj +1 more source
Gap junction expression and the effects of gap junction inhibitors in
, 2013 In this study, gap junction expression and the effects of estrogen deficiency and gap junction inhibitors were investigated in overactive bladder models which were created by bladder outlet obstruction. In our study, we created four groups as control, ovariectomy, bladder outlet obstruction (BOO), and ovariectomy + BOO.
Babaoglu, M +6 more
openaire +2 more sources
Gap junction implementation in multicellular 1-D cable.
, 2018 (A) three cells is connected by gap junction. (B) Evoked AP (V0) at cell 0 (R0), propagated AP (V1) at Cell 1 via one gap junction (R1), and propagated AP (V2) via two gap junctions (R2).
Keith L. Brain (190706) +2 more
core +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
New cellular mechanisms of gap junction degradation and recycling.
, 2015 International audienceConnexins (Cx), the constitutive proteins of gap junctions, are key actors of many physiological processes. Therefore alterations of Cx expression and degradation lead to the development of physiopathological disorders.
Georges Pointis +11 more
core +1 more source