Results 171 to 180 of about 217,542 (316)

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Biochemical and immunochemical analysis of the arrangement of connexin43 in rat heart gap junction membranes [PDF]

, 1990
Dale W. Laird, J P Revel
openalex   +1 more source

Visualization of Gap Junction-Mediated Astrocyte Coupling in Acute Mouse Brain Slices. [PDF]

Bio Protoc
Kompier NF, Siemonsmeier G, Meyer N, Kettenmann H, Rathjen FG.   +4 more
europepmc   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Reconstitution of native-type noncrystalline lens fiber gap junctions from isolated hemichannels. [PDF]

, 1994
J. Kistler, Kenneth N. Goldie, Paul J. Donaldson, Andreas Engel   +3 more
openalex   +1 more source

Acute ischaemia and gap junction modulation modify propagation patterns across Purkinje-myocardial junctions. [PDF]

Front Physiol
Jabbour RJ, Behradfar E, Debney M, Nygren A, Hartley A, Efimov I, Hocini M, Peters NS, Ng FS, Vigmond EJ.   +9 more
europepmc   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

An Extensive Gap Junction Neural Network Modulates <i>Caenorhabditis elegans</i> Aversive Behavior. [PDF]

Genes (Basel)
Sojka SE, Ezak MJ, Polk EA, Bischer AP, Neyland KE, Wojtovich AP, Ferkey DM.   +6 more
europepmc   +1 more source

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Gap junctions and tissue business: problems and strategies for developing specific functional reagents [PDF]

, 1993
Daniel A. Goodenough, Linda S. Musil
openalex   +1 more source