Results 181 to 190 of about 217,542 (316)

Structure of the connexin-43 gap junction channel in a putative closed state. [PDF]

Elife, 2023
Qi C, Acosta Gutierrez S, Lavriha P, Othman A, Lopez-Pigozzi D, Bayraktar E, Schuster D, Picotti P, Zamboni N, Bortolozzi M, Gervasio FL, Korkhov VM.   +11 more
europepmc   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Immunological evidence for gap junction polypeptide in plant cells.

, 1987
Scott J. Meiners, Melvin Schindler
openalex   +1 more source

The innexin 7 gap junction protein contributes to synchronized activity in the <i>Drosophila</i> antennal lobe and regulates olfactory function. [PDF]

Front Neural Circuits
Fuenzalida-Uribe N, Hidalgo S, Silva B, Gandhi S, Vo D, Zamani P, Holmes TC, Sayin S, Grunwald Kadow IC, Hadjieconomou D, O'Dowd DK, Campusano JM.   +11 more
europepmc   +1 more source

Mitochondrial Connexins and Mitochondrial Contact Sites with Gap Junction Structure. [PDF]

Int J Mol Sci, 2023
Cetin-Ferra S, Francis SC, Cooper AT, Neikirk K, Marshall AG, Hinton A, Murray SA.   +6 more
europepmc   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

Transcription of the gene for the gap junctional protein connexin43 and expression of functional cell-to-cell channels are regulated by cAMP. [PDF]

, 1992
Parmender P. Mehta, Masashi Yamamoto, B. Rose   +2 more
openalex   +1 more source

Developmental Changes in Gap Junction Expression in Rat Adrenal Medullary Chromaffin Cells. [PDF]

Acta Histochem Cytochem
Nakashima T, Wang KY, Matsuoka H, Ogawa K, Endo Y, Harada K, Inoue M.   +6 more
europepmc   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Gap junction intercellular communications regulates activation of SARM1 and protects against axonal degeneration. [PDF]

Cell Death Dis
Zhu WJ, Liu J, Li WH, Zhao ZY, Huang C, Yang JY, Lee HC, Zhao YJ.   +7 more
europepmc   +1 more source