Results 231 to 240 of about 393,906 (290)

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Innexin expression and localization in the Drosophila antenna indicate gap junction or hemichannel involvement in antennal chemosensory sensilla. [PDF]

Cell Tissue Res
Prelic S, Keesey IW, Lavista-Llanos S, Hansson BS, Wicher D.   +4 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Integrative analyses identified gap junction beta-2 as a prognostic biomarker and therapeutic target for breast cancer. [PDF]

Cancer Innov
Zhang D, Li L, Ma F.
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Gap-junction-mediated bioelectric signaling required for slow muscle development and function in zebrafish. [PDF]

Curr Biol
Lukowicz-Bedford RM, Eisen JS, Miller AC.   +2 more
europepmc   +1 more source

Regulation of serum reproductive hormones, gap junction proteins, and cytokine profiles in laying hens fed varying levels of expanded black soldier fly meal. [PDF]

Poult Sci
Tajudeen H, Hosseindoust A, Mun JY, Ha SH, Park SR, Silvestre PN, Kim MJ, Kim JS.   +7 more
europepmc   +1 more source

Modeling of auditory neuropathy spectrum disorders associated with the TEME43 variant reveals impaired gap junction function of iPSC-derived glia-like support cells. [PDF]

Front Mol Neurosci
Kang X, Ma L, Wen J, Gong W, Liu X, Hu Y, Feng Z, Jing Q, Cai Y, Li S, Cai X, Yuan K, Feng Y.   +12 more
europepmc   +1 more source

Electrocardiographic Effects of Bupropion Toxicity Suggesting Dysfunction of the Gap Junction or Connexin 43. [PDF]

Cureus
Bruss P, Hartle R, Astacio J, Chauhdri AF.   +3 more
europepmc   +1 more source

Connexin Gap Junction Channels and Hemichannels: Insights from High-Resolution Structures. [PDF]

Biology (Basel)
Jagielnicki M, Kucharska I, Bennett BC, Harris AL, Yeager M.   +4 more
europepmc   +1 more source