Results 141 to 150 of about 87,868 (301)

Loss and reappearance of gap junctions in regenerating liver [PDF]

, 1978
Changes in intercellular junctional morphology associated with rat liver regeneration were examined in a freeze-fracture study. After a two-thirds partial hepatectomy, both gap junctions and zonulae occludentes were drastically altered.
Yee, A. G., Revel, J.-P.
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Impact of spin-orbit coupling and Zeeman interaction on the multiple Andreev reflections subharmonic gap structure in nanoscopic Josephson junctions

Scientific Reports
Multiple Andreev reflections in voltage-biased Josephson junctions give rise to the subharmonic gap structure in the conductance, which is widely used to characterize transport properties and estimate the induced gap in the junctions.
Dibyendu Kuiri, Jorge Huamani Correa, Andrzej Biborski, Michał Piotr Nowak   +3 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Sources of Calcium at Connexin 36 Gap Junctions in the Retina. [PDF]

eNeuro, 2023
Lee YH, Kothmann WW, Lin YP, Chuang AZ, Diamond JS, O'Brien J.   +5 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Cx37 abhängige Calciumsignalausbreitung durch myoendotheliale Gap Junctions [PDF]

, 2015
Eine effektive Regulation der Gewebedurchblutung erfordert eine Koordination der Reaktion einzelner Gefäßzellen bzw. verschiedener Gefäßabschnitte.
Pintsch, Monika
core  

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Cytoplasmic Surface infrastructures of Gap Junctions in Bovine Lens Fibers [PDF]

, 1993
Purpose. To examine the cytoplasmic surface infrastructures of lens fiber gap junctions, where the cytoplasmic domains of connexons were expected to be exposed. Methods. Bovine lens fiber gap junctions, both in situ and in the form of isolated membranes,
Hiroshi Iida, Yosaburo Shibata, Akio Kuraoka, Tatsuhiko Hatae   +3 more
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Gap junctions in brain glial cells and development [PDF]

, 1995
International audienceIn mammalian brain, glia are likely the most abundant and widespread cell population connected by gap junctions. Here, we summarize recent findings concerning the distribution, expression, and regulation of gap junction proteins in ...
Giaume, C., Venance, L.
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