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Comprehensive Physiology, 2012
AbstractGap junctions are essential to the function of multicellular animals, which require a high degree of coordination between cells. In vertebrates, gap junctions comprise connexins and currently 21 connexins are known in humans. The functions of gap junctions are highly diverse and include exchange of metabolites and electrical signals between ...
Nielsen, Morten Schak +5 more
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AbstractGap junctions are essential to the function of multicellular animals, which require a high degree of coordination between cells. In vertebrates, gap junctions comprise connexins and currently 21 connexins are known in humans. The functions of gap junctions are highly diverse and include exchange of metabolites and electrical signals between ...
Nielsen, Morten Schak +5 more
+6 more sources
Annual Review of Physiology, 1981
The formation of low resistance pathways is one of the most common forms of cellular interaction. Since its discovery between neurons (40) this form of cell-to-cell communication has been documented widely in both excitable and nonexcitable cells.
E L, Hertzberg +2 more
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The formation of low resistance pathways is one of the most common forms of cellular interaction. Since its discovery between neurons (40) this form of cell-to-cell communication has been documented widely in both excitable and nonexcitable cells.
E L, Hertzberg +2 more
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Journal of Cell Science, 1977
ABSTRACT Both glycerol and glutaraldehyde, the two most commonly used chemical aids in freeze-fracture studies, have been shown individually to affect the structure of certain membranes as observed in freeze-fracture replicas. The present investigation studied the effect of glycerol on the gap junctions found in a number of tissues from ...
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ABSTRACT Both glycerol and glutaraldehyde, the two most commonly used chemical aids in freeze-fracture studies, have been shown individually to affect the structure of certain membranes as observed in freeze-fracture replicas. The present investigation studied the effect of glycerol on the gap junctions found in a number of tissues from ...
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Journal of Cell Science, 1988
ABSTRACT Gap junctions are intercellular structures that link cells and allow them to exchange ions and small metabolites without recourse to the extracellular space (for reviews and early references, see Goodenough, 1979; Loewen-stein, 1981).
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ABSTRACT Gap junctions are intercellular structures that link cells and allow them to exchange ions and small metabolites without recourse to the extracellular space (for reviews and early references, see Goodenough, 1979; Loewen-stein, 1981).
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2023
Gap junctions, comprising connexin proteins, create conduits directly coupling the cytoplasms of adjacent cells. Expressed in essentially all tissues, dynamic gap junction structures enable the exchange of small molecules including ions and second messengers, and are central to maintenance of homeostasis and synchronized excitability. With such diverse
Michael J, Zeitz, James W, Smyth
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Gap junctions, comprising connexin proteins, create conduits directly coupling the cytoplasms of adjacent cells. Expressed in essentially all tissues, dynamic gap junction structures enable the exchange of small molecules including ions and second messengers, and are central to maintenance of homeostasis and synchronized excitability. With such diverse
Michael J, Zeitz, James W, Smyth
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Annual Review of Physiology, 1985
Gap junctions [also called nexus (15) or maculae communicantes (102)] repre sent transcellular channels that permit the exchange of small molecules and ions between neighboring cells (28, 33, 74, 75, 82, 86, 89, 103). They differ from other membrane channels in a number of respects: they provide a pathway between cells rather than across one cell ...
Revel, J.-P. +2 more
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Gap junctions [also called nexus (15) or maculae communicantes (102)] repre sent transcellular channels that permit the exchange of small molecules and ions between neighboring cells (28, 33, 74, 75, 82, 86, 89, 103). They differ from other membrane channels in a number of respects: they provide a pathway between cells rather than across one cell ...
Revel, J.-P. +2 more
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Seminars in Cell Biology, 1992
Gap junction channels, now known to be formed of connexins, connect the interiors of apposed cells. These channels can be opened and closed by various physiological stimuli and experimental treatments. They are permeable to ions and neutral molecules up to a size of about 1 kDa or 1.5 nm diameter, including second messengers and metabolites.
M V, Bennett, V K, Verselis
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Gap junction channels, now known to be formed of connexins, connect the interiors of apposed cells. These channels can be opened and closed by various physiological stimuli and experimental treatments. They are permeable to ions and neutral molecules up to a size of about 1 kDa or 1.5 nm diameter, including second messengers and metabolites.
M V, Bennett, V K, Verselis
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Gap junctional communication during neuromuscular junction formation
Neuron, 1991We have tested whether gap junctions form between nerve and muscle during their initial contact, before establishing the chemical synapse. Embryonic Xenopus stage 18-20 myotomes and neural tubes were permeabilized with DMSO to load appropriate reagents, dissociated, and cocultured.
F, Allen, A, Warner
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Nonredundant Gap Junction Functions
Physiology, 2003The need for molecular heterogeneity of gap junction channel proteins in vivo has been enigmatic. Recently, functional replacement of one channel gene with another in mice and flies has revealed that cellular health depends not simply on gap junction communication but also requires the correct type of intercellular channel subunit.
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