Results 51 to 60 of about 1,721,078 (258)
Gap Junctions Regulate Seizure Activity – But in Unexpected Ways
, 2013 Seizures are a poorly understood neurophysiological state epitomized by hypersynchronous excitatory brain activity. This chapter will explore the experimental and theoretical basis for the involvement of gap junctions in the generation of seizure ...
Voss, LJ +3 more
core +1 more source
AGE-BSA down-regulates endothelial connexin43 gap junctions
BMC Cell Biology, 2011 Background Advanced glycation end products generated in the circulation of diabetic patients were reported to affect the function of vascular wall. We examined the effects of advanced glycation end products-bovine serum albumin (AGE-BSA) on endothelial ...
Wang Hsueh-Hsiao +6 more
doaj +1 more source
Understanding the Molecular and Cell Biological Mechanisms of Electrical Synapse Formation
Frontiers in Neuroanatomy, 2020 In this review article, we will describe the recent advances made towards understanding the molecular and cell biological mechanisms of electrical synapse formation. New evidence indicates that electrical synapses, which are gap junctions between neurons,
E. Anne Martin +2 more
doaj +1 more source
Gap Junctions Contribute to the Regulation of Walking-Like Activity in the Adult Mudpuppy (Necturus Maculatus). [PDF]
PLoS ONE, 2016 Although gap junctions are widely expressed in the developing central nervous system, the role of electrical coupling of neurons and glial cells via gap junctions in the spinal cord in adults is largely unknown.
Igor Lavrov +4 more
doaj +1 more source
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Molecular and functional characterization of gap junctions in the avian inner ear. [PDF]
, 2006 To analyze the fundamental role of gap junctions in the vertebrate inner ear, we examined molecular and functional characteristics of gap junctional communication (GJC) in the auditory and vestibular system of the chicken.
Nickel, R, Becker, D, Forge, A
core
, 2013 SummaryIn vertebrates and invertebrates, signaling among neurons is most commonly mediated by chemical synapses. At these synapses neurotransmitter released by presynaptic neurons is detected by receptors on the postsynaptic neurons, leading to an influx
Stopfer, Mark, Shimizu, Kazumichi
core +1 more source
Modelling the effect of gap junctions on tissue-level cardiac electrophysiology [PDF]
Electronic Proceedings in Theoretical Computer Science, 2012 When modelling tissue-level cardiac electrophysiology, continuum approximations to the discrete cell-level equations are used to maintain computational tractability.
Doug Bruce +2 more
doaj +1 more source