Results 91 to 100 of about 22,095 (292)

STING deficiency promotes motor recovery in mice following brachial plexus root avulsion

Animal Models and Experimental Medicine, EarlyView.
STING deficiency can increase the body weight, promote motor recovery, decrease MN death, inhibit pyroptosis and neuroinflammation, increase remyelination, and reduce the atrophy of the biceps brachii in mice with BPRA. Abstract Background Brachial plexus root avulsion (BPRA), a well‐known form of peripheral nerve injury, results in motor function loss
Yu Peng, Ying Zhang, Shenhui Yang, Lu He, Shuangxi Chen   +4 more
wiley   +1 more source

Triggering Pyroptosis in Cancer

Biomolecules
Pyroptosis is an inflammatory programmed cell death recently identified as a crucial cellular process in various diseases, including cancers. Unlike other forms of cell death, canonical pyroptosis involves the specific cleavage of gasdermin by caspase-1,
Daniel E. Johnson, Zhibin Cui
doaj   +1 more source

Lung eQTLs to Help Reveal the Molecular Underpinnings of Asthma [PDF]

, 2012
Genome-wide association studies (GWAS) have identified loci reproducibly associated with pulmonary diseases; however, the molecular mechanism underlying these associations are largely unknown.
Bosse, Yohan, Brandsma, Corry-Anke, Couture, Christian, Curtis, Sean P., Daley, Denise, Derry, Jonathan M., Elliott, W. Mark, Hackett, Tillie L., Hao, Ke, Hogg, James C., Koppelman, Gerard, Kulkarni, Amit, Lamontagne, Maxime, Laviolette, Michel, Malkov, Vladislav, Nicholson, Donald W., Nickle, David C., Opiteck, Greg J., Pare, Peter D., Postma, Dirkje S., Reicin, Alise S., Sandford, Andrew, Sin, Don D., Suver, Christine, Timens, Wim, Tsou, Jeffrey A., van den Berge, Maarten, Vessey, Rupert, Zhang, Chunsheng   +28 more
core   +4 more sources

A cooperative release of mitochondrial DNA from platelets and neutrophils drives an interferon signature in systemic sclerosis

Arthritis &Rheumatology, Accepted Article.
Objective Mitochondria are organelles with a hypomethylated circular genome. Mitochondrial DNA (mtDNA) in the systemic circulation has been implicated in inflammation. This study investigates the role of circulating DNA in systemic sclerosis (SSc) and the cellular mechanisms governing its release.
Stavros Giaglis, André N. Tiaden, Simone Häner‐Massimi, Diego Kyburz, Cedric André, Anton Glück, Enrico Ferrero, Stuart Hawtin, Tobias Junt, Ulrich A. Walker   +9 more
wiley   +1 more source

Zebrafish in Inflammasome Research

Cells, 2019
Inflammasomes are cytosolic multiprotein complexes that regulate inflammatory responses to danger stimuli and infection, and their dysregulation is associated with an increasing number of autoinflammatory diseases.
Gabriel Forn-Cuní, Annemarie H. Meijer, Monica Varela   +2 more
doaj   +1 more source

Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. [PDF]

, 2011
Asthma is a common disease with a complex risk architecture including both genetic and environmental factors. We performed a meta-analysis of North American genome-wide association studies of asthma in 5,416 individuals with asthma (cases) including ...
Abel, Rebekah A, Adkinson, N Franklin, Ampleford, Elizabeth J, Avila, Lydiana, Avila, Pedro C, Barnes, Kathleen C, Baurley, James W, Beaty, Terri H, Bleecker, Eugene R, Burchard, Esteban G, Busse, William W, Calhoun, William J, Capurso, Daniel, Castro, Mario, Celedón, Juan C, Chapela, Rocio, Childhood Asthma Management Program (CAMP), Childhood Asthma Research and Education (CARE) Network, Children's Health Study (CHS) and HARBORS study, Chiu, Grace Y, Chung, Kian Fan, Conti, David V, Deichmann, Klaus A, del Rio-Navarro, Blanca, Diette, Gregory B, Dunston, Georgia M, Eng, Celeste, Ezurum, Serpil C, Faruque, Mezbah U, Ford, Jean G, Galanter, Joshua, Gauderman, W James, Genetic Research on Asthma in African Diaspora (GRAAD) Study, Genetics of Asthma in Latino Americans (GALA) Study, Study of Genes-Environment and Admixture in Latino Americans (GALA2) and Study of African Americans, Asthma, Genes & Environments (SAGE), Gern, James E, Gignoux, Christopher R, Gilliland, Frank D, Graves, Penelope E, Hancock, Dana B, Hansel, Nadia N, Heinzmann, Andrea, Hernandez, Ryan D, Himes, Blanca E, Hu, Donglei, Huntsman, Scott, Israel, Elliott, Lemanske, Robert F, Levin, Albert M, Li, Xia, Li, Xingnan, Liang, Liming, London, Stephanie J, Mantese, Vito J, Martinez, Fernando D, Mathias, Rasika A, Mexico City Childhood Asthma Study (MCAAS), Meyers, Deborah A, Myers, Rachel A, Nicolae, Dan L, Ober, Carole, Raby, Benjamin A, Rafaels, Nicholas, Rodriguez-Cintron, William, Rodriquez-Santana, Jose R, Romieu, Isabelle, Ross, Kevin D, Roth, Lindsey A, Ruczinski, Ingo, Salam, Muhammad T, Shi, Min, Sienra-Monge, Juan J, Soto-Quiros, Manuel, Stern, Debra A, Study of Asthma Phenotypes and Pharmacogenomic Interactions by Race-Ethnicity (SAPPHIRE), Togias, Alkis, Torgerson, Dara G, Van Den Berg, David J, Vora, Hita, Watson, Harold R, Weiss, Scott T, Wenzel, Sally E, Williams, L Keoki   +81 more
core   +2 more sources

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source

REAGENT or RESOURCE from USP48 Stabilizes Gasdermin E to Promote Pyroptosis in Cancer [PDF]

, 2023
Yidan Ren, Maoxiao Feng, Xiaodong Hao, Xiaoyan Liu, Juan Li, Peilong Li, Jie Gao, Qiuchen Qi, Lutao Du, Chuanxin Wang, Qin Wang, Yunshan Wang   +11 more
openalex   +1 more source

Cardamonin Commands the Colonic Metabolite Columbianetin Acetate to Compete Against LPS in Binding HMGB1 in the Kidney, Preventing Lipopolysaccharide‐Induced Renal Tubular Pyroptosis

Food Frontiers, EarlyView.
Cardamonin upregulate sd the intestinal metabolite columbianetin acetate, which competitively bound HMGB1 to prevent LPS‐induced renal tubular cell pyroptosis (the figure is created with BioRender). ABSTRACT Sepsis‐associated acute kidney injury (SA‐AKI) results in high mortality due to the lack of effective interventions. The current study reports the
Zihui Zhou, Xuechun Sun, Jian Zhou, Huali Meng, Pengfei Fan, Yufeng Chu, Hao Wu   +6 more
wiley   +1 more source

Caspase-5: Structure, Pro-Inflammatory Activity and Evolution

Biomolecules
Caspase-5 is a protease that induces inflammation in response to lipopolysaccharide (LPS), a component of the cell envelope of Gram-negative bacteria. The expression level of the CASP5 gene is very low in the basal state, but strongly increases in the ...
Leopold Eckhart, Heinz Fischer
doaj   +1 more source