Results 151 to 160 of about 22,095 (292)

Oxidative Stress: Molecular Mechanisms, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Oxidative stress occurs when the reactive oxygen species (ROS) production overwhelms the ROS scavenging, which lead to genomic instability, epigenetic regulation, proteostasis imbalance, and lipid peroxidation, subsequently causing the occurrence and development of numerous diseases. ABSTRACT Although the physiological level of reactive oxygen species (
Yi Qin, Chen Qian, Wenhao Li, Qihan Wang, Qifeng Sheng, Zheqing Chen, Wei Zhang, Wenming Li, Gaoran Ge, Zhanjun Yan, Dechun Geng   +10 more
wiley   +1 more source

Caspase-1 activates gasdermin A in non-mammals

eLife
Gasdermins oligomerize to form pores in the cell membrane, causing regulated lytic cell death called pyroptosis. Mammals encode five gasdermins that can trigger pyroptosis: GSDMA, B, C, D, and E.
Zachary Paul Billman, Stephen Bela Kovacs, Bo Wei, Kidong Kang, Ousmane H Cissé, Edward A Miao   +5 more
doaj   +1 more source

Is Ferroptosis the Mechanistic Bridge Connecting Iron Dysregulation to Muscle Wasting and Functional Decline in Aging?

Aging Cell, Volume 25, Issue 2, February 2026.
This work proposes ferroptosis as a mechanistic driver of age‐related muscle dysfunction, whereby iron dyshomeostasis and impaired antioxidant capacity promote lipid peroxidation, and eventually trigger ferroptosis, leading to muscle wasting, and ultimately contributing to weakness and functional decline with aging.
Rola S. Zeidan, Simon Reinhard, Anna Picca, Emanuele Marzetti, Christiaan Leeuwenburgh, James F. Collins, Stephen D. Anton   +6 more
wiley   +1 more source

GSDME in cardiovascular diseases: research system and contemporary progress

Frontiers in Immunology
Despite considerable advancements in treatment technologies in recent years, cardiovascular diseases still pose a significant threat to human health.
Zhenzhen Yang, Zilong Luo, Han Zhang, Han Zhang, Junjie Zong, Junjie Zong, Pinyan Huang, Pinyan Huang, Yuqing Niu, Cheng Zhou, Cheng Zhou, Song Wang, Song Wang, Dan Zhang, Dan Zhang   +14 more
doaj   +1 more source

Neuroprotective effects of sinomenine and metformin in diabetic stroke: Role of NLRP3/caspase‐1 and mitophagy

Experimental Physiology, Volume 111, Issue 2, Page 489-500, 1 February 2026.
Abstract Type 2 diabetes mellitus (T2DM) significantly increases the risk and severity of cerebral ischaemia–reperfusion (IR) injury, yet effective neuroprotective treatments for diabetic stroke remain limited. This study explored whether a combination of sinomenine and metformin could offer enhanced neuroprotection in diabetic rats subjected to ...
Wendi Li, Yiying Fan, Shaik Althaf Hussain   +2 more
wiley   +1 more source

The CCL11‐CCR3 Axis Regulates the Aggravation of Neuroinflammation in Astrocytic Necroptosis After Cerebral Ischemia

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
Schematic diagram of the triggering mechanism of necroptosis after cerebral ischemia. First, CCL11 targetedly binds to CCR3 on the surface of astrocytes and upregulates the expression of CCR3. After CCR3 activation, it triggers the transcriptional activation of necroptosis.
Han Yin, Xinmin Zhang, Meng Li, Yunzhe Liu, Yingying Zhang, Yao Zhang, Hui Ci, Kun Li, ShanShan Yang, Guangyou Wang, Tongshuai Zhang   +10 more
wiley   +1 more source

Role of gasdermins in chronic kidney disease

Frontiers in Immunology
Gasdermins (GSDMs), functioning as membrane perforating proteins, can be activated by canonical inflammasomes, noncanonical inflammasomes, as well as non-inflammasomes, leading to cell pyroptosis and the subsequent release of inflammatory mediators.
Hanchao Gao, Ting Xie, Yunyi Li, Zigan Xu, Zhuoheng Song, Huixia Yu, Hongming Zhou, Weilong Li, Chen Yun, Baozhang Guan, Shaodong Luan, Lianghong Yin   +11 more
openaire   +3 more sources

Mechanistic Insights into Gasdermin Pore Formation and Regulation in Pyroptosis

, 2021
Chengliang Wang, Jianbin Ruan
openalex   +2 more sources

The expression profile of Gasdermin C-related genes predicts the prognosis and immunotherapy response of pancreatic adenocarcinoma. [PDF]

, 2023
Xiang-Hou Xia, Wenjuan Yin, Jiefei Mao, Peng Liu, Chen-Dong Qin, Jiejie Hu, Siyuan Liu, Canming Wang, Dehong Zou, Hongjian Yang, Yang Yu, Jian Huang   +11 more
openalex  

Gasdermin D Protects Mouse Podocytes Against High-Glucose-Induced Inflammation and Apoptosis via the C-Jun N-Terminal Kinase (JNK) Pathway

, 2021
Huifang Li, Kunxiao Zhao, Ying Li
openalex   +1 more source