Results 161 to 170 of about 24,180 (354)

Unlocking the potential of pyroptosis in tumor immunotherapy: a new horizon in cancer treatment

Frontiers in Immunology
BackgroundThe interaction between pyroptosis—a form of programmed cell death—and tumor immunity represents a burgeoning field of interest. Pyroptosis exhibits a dual role in cancer: it can both promote tumor development and counteract it by activating ...
Qinan Yin, Qinan Yin, Si-Yuan Song, Yuan Bian, Yuan Bian, Yiping Wang, Anchen Deng, Jianzhen Lv, Yi Wang, Yi Wang   +9 more
doaj   +1 more source

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages [PDF]

, 2017
Charles L. Evavold, Jianbin Ruan, Yunhao Tan, Shiyu Xia, Hao Wu, Jonathan C. Kagan   +5 more
openalex   +1 more source

Caspase-1 activates gasdermin A in non-mammals

eLife
Gasdermins oligomerize to form pores in the cell membrane, causing regulated lytic cell death called pyroptosis. Mammals encode five gasdermins that can trigger pyroptosis: GSDMA, B, C, D, and E.
Zachary Paul Billman, Stephen Bela Kovacs, Bo Wei, Kidong Kang, Ousmane H Cissé, Edward A Miao   +5 more
doaj   +1 more source

Monitoring gasdermin pore formation in vitro

, 2019
The gasdermin (GSDM) family consists of gasdermin A (GSDMA), B (GSDMB), C (GSDMC), D (GSDMD), E or DNFA5 (GSDME), and DFNB59 in human. Expressed in the skin, gastrointestinal tract, and various immune cells, GSDMs mediate homeostasis and inflammation upon activation by caspases and unknown proteases.
Jianbin Ruan, Jianbin Ruan, Shiyu Xia, Hao Wu, Hao Wu   +4 more
openaire   +4 more sources

Role of RIPK1/RIPK3/MLKL signalling pathway in sepsis‐associated acute kidney injury

Experimental Physiology, EarlyView.
Abstract Sepsis‐associated acute kidney injury (SA‐AKI) is a common clinical syndrome in critically ill patients, and its high mortality rate is closely related to complex pathological mechanisms. Existing studies have shown that the pathophysiological process of SA‐AKI involves complex multi‐mechanism interactions, including an uncontrolled systemic ...
Huijun Yin, Jingyi Wang, Huirong Han
wiley   +1 more source

Expression characteristics of dual‐specificity phosphatase 2 and hypoxia‐inducible factor‐1α in acute kidney injury and preliminary study of the effect of dual‐specificity phosphatase 2 on HK‐2 cells

Experimental Physiology, EarlyView.
ABSTRACT Acute kidney injury (AKI) is a global health problem with significant long‐term harm if the prognosis is poor. Dual‐specificity phosphatase 2 (DUSP2) is involved in key regulatory pathways in several disease processes, but its function in renal pathophysiology is unclear.
Xueqian Chu, Songmin Xue, Lanyan Lin, Xuan Huang, Sisi Chen, Wulaer Adeli, Zulibiya Tuohetiyaer, Suhua Li, Chen Lu   +8 more
wiley   +1 more source

Neuroprotective effects of sinomenine and metformin in diabetic stroke: Role of NLRP3/caspase‐1 and mitophagy

Experimental Physiology, EarlyView.
Abstract Type 2 diabetes mellitus (T2DM) significantly increases the risk and severity of cerebral ischaemia–reperfusion (IR) injury, yet effective neuroprotective treatments for diabetic stroke remain limited. This study explored whether a combination of sinomenine and metformin could offer enhanced neuroprotection in diabetic rats subjected to ...
Wendi Li, Yiying Fan, Shaik Althaf Hussain   +2 more
wiley   +1 more source

Jefferson Digital Commons quarterly report: April-June 2019 [PDF]

, 2018
This quarterly report includes: Articles CREATE Day Presentations Dissertations From the Archives Grand Rounds and Lectures House Staff Quality Improvement and Patient Safety Posters JCIPE Student Hotspotting Posters Journals and Newsletters MPH ...
Copeland, LIBT, James, Duinkerken, MSI, Kelsey   +1 more
core   +2 more sources

Microparticulate Caspase 1 Regulates Gasdermin D and Pulmonary Vascular Endothelial Cell Injury [PDF]

, 2018
Srabani Mitra, Matthew C. Exline, Fabien Habyarimana, Mikhail A. Gavrilin, Paul J. Baker, Seth L. Masters, Mark D. Wewers, Anasuya Sarkar   +7 more
openalex   +1 more source

Separase Inhibition Enhances Gefitinib Sensitivity of Lung Cancer via PTBP1/TAK1/RIPK1‐Mediated PANoptosis

MedComm, Volume 6, Issue 11, November 2025.
Inhibiting separase with the specific inhibitor Sepin‐1 has been found to effectively enhance gefitinib‐induced cytotoxic in lung cancer cell. Mechanically, separase inhibitor Sepin‐1 plus gefitinib decreases the expression of PTBP1 and TAK1 to trigger RIPK1‐dependent PANoptosis. ABSTRACT Gefitinib is the most frequently employed anti‐lung cancer drug,
Zhouyangfan Peng, Liangpeng Xie, Sufang Zhou, Yapei Li   +3 more
wiley   +1 more source