Results 181 to 190 of about 24,180 (354)

Ligilactobacillus Murinus and Lactobacillus Johnsonii Suppress Macrophage Pyroptosis in Atherosclerosis through Butyrate‐GPR109A‐GSDMD Axis

Advanced Science, Volume 12, Issue 38, October 13, 2025.
Oral aspirin administration induces intestinal expansion of Lactobacillus murinus and Lactobacillus johnsonii, which suppresses the progression of atherosclerosis. This microbial expansion significantly enhances butyrate production by providing lactate as a metabolic substrate, thereby fostering the growth of butyrate‐producing bacteria. Butyrate plays
Rui Hua, Ning Ding, Yiming Hua, Xiaoke Wang, Yu Xu, Xiangrui Qiao, Xue Shi, Ting Bai, Ying Xiong, Xiaozhen Zhuo, Chong Fan, Juan Zhou, Yue Wu, Junhui Liu, Zuyi Yuan, Ting Li   +15 more
wiley   +1 more source

Gasdermins: a dual role in pyroptosis and tumor immunity

Frontiers in Immunology
The gasdermin (GSDM) protein family plays a pivotal role in pyroptosis, a process critical to the body’s immune response, particularly in combatting bacterial infections, impeding tumor invasion, and contributing to the pathogenesis of various ...
Jiayi Yang, Jiayi Yang, Jiayi Yang, Jingting Jiang, Jingting Jiang, Jingting Jiang   +5 more
doaj   +1 more source

Intracellular Delivery of an Antibody Targeting Gasdermin-B Reduces HER2 Breast Cancer Aggressiveness [PDF]

, 2019
Ángela Molina-Crespo, Ana Cadete, David Sarrió, Manuel Gámez-Chiachio, Lidia Martínez, Kinlin Chao, Olivera Ana, Andrea Gonella, Eva Díaz, José Palacios, Pradeep K. Dhal, Magnus Besev, Macarena Rodríguez‐Serrano, Laura García‐Bermejo, Juan Carlos Triviño, Amparo Cano, Marcos García-Fuentes, Osnat Herzberg, Dolores Torres, Marı́a José Alonso, Gema Moreno‐Bueno   +20 more
openalex   +1 more source

IL1β Promotes Immune Suppression in the Tumor Microenvironment Independent of the Inflammasome and Gasdermin D [PDF]

, 2020
Máté Kiss, Lieselotte Vande Walle, Pedro Saavedra, Els Lebegge, Helena Van Damme, Aleksandar Murgaski, Jun Qian, Manuel Ehling, Samantha Pretto, Evangelia Bolli, Jiri Keirsse, Pauline M. R. Bardet, Sana M. Arnouk, Yvon Elkrim, Maryse Schmoetten, Jan Brughmans, Ayla Debraekeleer, Amelie Fossoul, Louis Boon, Geert Raes, Geert Loo, Diether Lambrechts, Massimiliano Mazzone, Alain Beschin, Andy Wullaert, Mohamed Lamkanfi, Jo A. Van Ginderachter, Damya Laoui   +27 more
openalex   +1 more source

Autophagic Degradation of Gasdermin D Protects against Nucleus Pulposus Cell Pyroptosis and Retards Intervertebral Disc Degeneration In Vivo [PDF]

, 2021
Zhiwei Liao, Suyun Li, Rong Liu, Xiaobo Feng, Yunsong Shi, Kun Wang, Shuai Li, Yukun Zhang, Xinghuo Wu, Yang Cao   +9 more
openalex   +1 more source

Cardiovascular Disease Meets Cancer: Exploring the Epidemiology in China and Homotherapy Targeting Intersectional Mechanisms

Advanced Science, Volume 12, Issue 37, October 6, 2025.
Cardiovascular disease (CVD) and cancer are leading causes of death worldwide, with overlapping risk factors and pathophysiological mechanisms. This review explores shared pathways, including metabolic dysregulation, chronic inflammation, and gut microbiome alterations, highlighting dual‐benefit strategies such as lifestyle modifications and repurposed
Shihan Xiang, Yujie Shan, Shihong Xu, Jing Wang, Meng Luo, Jiaojiao Zhou, Qishan Chen   +6 more
wiley   +1 more source

Gasdermin D activity in inflammation and host defense [PDF]

, 2019
Judy Lieberman, Hao Wu, Jonathan C. Kagan   +2 more
openalex   +1 more source

Gasdermin E-derived caspase-3 inhibitors effectively protect mice from acute hepatic failure [PDF]

, 2020
Wanfeng Xu, Quan Zhang, Chujie Ding, Huiyong Sun, Yuan Che, Hai Huang, Yun Wang, Jiawei Wu, Haiping Hao, Lijuan Cao   +9 more
openalex   +1 more source

Critical Role of IL1R2‐ENO1 Interaction in Inhibiting Glycolysis‐Mediated Pyroptosis for Protection Against Lethal Sepsis

Advanced Science, Volume 12, Issue 39, October 20, 2025.
The authors have discovered that intracellular interleukin 1 receptor 2 (IL1R2) negatively regulates pyroptosis and inflammation by inhibiting glycolysis in sepsis. Soluble IL1R2 is released from macrophages undergoing pyroptosis. IL1R2 acts as a novel negative regulator of glycolysis by interacting with enolase 1 (ENO1), thereby inhibiting gasdermin D
Chuyi Tan, Han Ma, Jespar Chen, Gaifeng Ma, Alok Jha, Sipin Tan, Yaxi Zhu, Meidong Liu, Ke Liu, Xianzhong Xiao, Monowar Aziz, Huan Chen, Ping Wang, Huali Zhang   +13 more
wiley   +1 more source

Targeting Hyperglycemic Bone Pre‐Metastatic Niche for Breast Cancer Bone Metastasis Therapy

Advanced Science, Volume 12, Issue 37, October 6, 2025.
This study reveals that breast cancer creates a hyperglycemic pre‐metastatic niche in bone prior to colonization and amplifies glucose metabolism post‐metastasis. To target this mechanism, a biomimetic enzyme‐engineered nanoplatform that disrupts tumor glycolytic pathways, proposing a therapeutic strategy to inhibit breast cancer bone metastasis by ...
Jianxin Ye, Peng Hu, Rui Zhang, Lei Zhou, Zonghua Luo, Yanan Chen, Shengzhe Ruan, Mengyi Zhu, Huaze Ding, Yike Qian, Yan Xing, Tong Meng, Changping Wang, Dianwen Song   +13 more
wiley   +1 more source