Results 211 to 220 of about 24,180 (354)
Editorial: Gasdermins in the defense against pathogens
Frontiers in Immunology, 2023 Eckhart, Leopold, Chen, Ruochan
openaire +3 more sources
Tubular Injury in Diabetic Kidney Disease: Early Diagnosis and Intervention Strategies
Diabetes/Metabolism Research and Reviews, Volume 41, Issue 7, October 2025.ABSTRACT Diabetic kidney disease (DKD) is the most severe complication of diabetes mellitus and has poor prognosis, often progressing to end‐stage renal disease, causing substantial morbidity and mortality globally. While the pathogenesis of DKD has been extensively characterised, including glomerular hyperfiltration, podocyte injury, and ...
Yi Lv +7 more
wiley +1 more source
Pyolysin of Trueperella pyogenes Induces Pyroptosis and IL-1β Release in Murine Macrophages Through Potassium/NLRP3/Caspase-1/Gasdermin D Pathway [PDF]
, 2022 Hongmin Liang +4 more
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Gasdermin D pore structure reveals preferential release of mature interleukin-1
Nature, 2021 S. Xia +12 more
semanticscholar +1 more source
Novel pyroptosis-independent functions of gasdermins
Signal Transduction and Targeted Therapy, 2022 Ziran Qin, Fangfang Zhou, Long Zhang
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ESC Heart Failure, Volume 12, Issue 5, Page 3601-3613, October 2025.Abstract Aims Targeting inflammasomes in heart failure (HF) might represent a novel therapeutic option. Nevertheless, previous studies focused only on myocardial inflammasome alterations, and data are scarce regarding their regulation and role in HF‐associated multiorgan dysfunction.
Dávid Nagy +12 more
wiley +1 more source
Journal of Biochemical and Molecular Toxicology, Volume 39, Issue 10, October 2025.TIPE2 directly interacted with the E3 ubiquitin ligase FBW1A and positively regulated its expression. TIPE2/FBW1A complex could regulate ubiquitination degradation of C1qbp and then inhibit NLRP3 inflammasome activation to suppress oxidative stress and inflammation in bronchial epithelial cells, thus improved respiratory function and pulmonary tissue ...
Wei Li +6 more
wiley +1 more source
Gasdermin D pore-forming activity is redox-sensitive
Cell Reports, 2023 Pascal Devant +8 more
semanticscholar +1 more source
MedComm, Volume 6, Issue 10, October 2025.This review comprehensively examines the regulatory mechanisms and physiological roles of guanine nucleotide exchange factors (GEFs) and their small GTPase substrates, highlighting their significance in cellular processes and disease pathogenesis.
Zexing Lin +15 more
wiley +1 more source