Results 191 to 200 of about 20,660 (301)

Data from IL1β Promotes Immune Suppression in the Tumor Microenvironment Independent of the Inflammasome and Gasdermin D

, 2023
Máté Kiss, Lieselotte Vande Walle, Pedro Saavedra, Els Lebegge, Helena Van Damme, Aleksandar Murgaski, Junbin Qian, Manuel Ehling, Samantha Pretto, Evangelia Bolli, Jiri Keirsse, Pauline M. R. Bardet, Sana M. Arnouk, Yvon Elkrim, Maryse Schmoetten, Jan Brughmans, Ayla Debraekeleer, Amelie Fossoul, Louis Boon, Geert Raes, Geert Loo, Diether Lambrechts, Massimiliano Mazzone, Alain Beschin, Andy Wullaert, Mohamed Lamkanfi, Jo A. Van Ginderachter, Damya Laoui   +27 more
openalex   +1 more source

The NLRP3 Inflammasome: Mechanisms of Activation, Regulation, and Therapeutic Opportunities

MedComm, Volume 7, Issue 3, March 2026.
Diverse diseases converge on NLRP3. We depict a discovery‐to‐clinic track: high‐throughput/phenotypic screens, structure‐guided design, and modality innovation (allosteric inhibitors, interface blockers, degraders) deliver third‐generation, disease‐tailored NLRP3 control.
Chan Zou, Shilong Jiang, Hui Li, Kai Zhao, Dongshen Cao, Guoping Yang   +5 more
wiley   +1 more source

Emestrin-Type Epidithiodiketopiperazines Inhibited Gasdermin D-Mediated Pyroptosis via Caspase-3/7 Activation. [PDF]

MedComm (2020)
Geng B, Lin S, Yim WY, Sun W, Zhang X, Ma C, Zhang Z, Guo Q, Gao J, Zeng H, Tong Q, Wang Y, Fan Z, Hou J, Li M, Zhang Y, Hu Z.   +16 more
europepmc   +1 more source

A new lead to NLRP3 inhibition [PDF]

, 2017
Dixit, Vishva M, Lamkanfi, Mohamed
core   +2 more sources

Additional file 3 of GASDERMIN D-mediated pyroptosis as a therapeutic target in TAU-dependent frontotemporal dementia mouse model

Ignacio Silva-Llanes, Lilia A. Smith, Aaron Abdelkader-Guillén, José Jiménez-Villegas, David Sarrió, Moreno‐Bueno Gema, Isabel Lastres-Becker   +6 more
openalex   +1 more source

Determination of the Roles of H. pylori Outer Membrane Virulence Factors and Pyroptosis-Associated NLRP3, ASC, Caspase-1, Gasdermin D, IL-1β, and IL-18 in Ulcer and Gastritis Pathogenesis [PDF]

Yaren Büyükcolak-Cebeci, Emel Timuçin, Sümeyye Akcelik-Deveci, Nesteren Mansur-Ozen, Tuana Aydinlar, Arzu Tiftikçi, Sinem Öktem Okullu   +6 more
openalex   +1 more source

Supplementary Figures 1-11 from IL1β Promotes Immune Suppression in the Tumor Microenvironment Independent of the Inflammasome and Gasdermin D

, 2023
Máté Kiss, Lieselotte Vande Walle, Pedro Saavedra, Els Lebegge, Helena Van Damme, Aleksandar Murgaski, Junbin Qian, Manuel Ehling, Samantha Pretto, Evangelia Bolli, Jiri Keirsse, Pauline M. R. Bardet, Sana M. Arnouk, Yvon Elkrim, Maryse Schmoetten, Jan Brughmans, Ayla Debraekeleer, Amelie Fossoul, Louis Boon, Geert Raes, Geert Loo, Diether Lambrechts, Massimiliano Mazzone, Alain Beschin, Andy Wullaert, Mohamed Lamkanfi, Jo A. Van Ginderachter, Damya Laoui   +27 more
openalex   +2 more sources

GASDERMIN D-mediated pyroptosis as a therapeutic target in TAU-dependent frontotemporal dementia mouse model. [PDF]

J Biomed Sci
Silva-Llanes I, Smith LA, Abdelkader-Guillén A, Jiménez-Villegas J, Sarrió D, Moreno-Bueno G, Lastres-Becker I.   +6 more
europepmc   +1 more source

Therapeutic Efficacy of the Supersulfide Donor NAC‐S2 in Influenza Virus Pneumonia via Suppression of Excessive Inflammatory Responses

Microbiology and Immunology, Volume 70, Issue 3, Page 148-159, March 2026.
ABSTRACT Influenza pneumonia is characterized by excessive inflammatory responses that contribute to severe lung injury and mortality. Supersulfides, endogenously produced cysteine‐derived persulfides and polysulfides, exert potent antioxidant, anti‐ferroptotic, and anti‐inflammatory activities; however, their therapeutic potential after disease onset ...
Foysal Hossen, Takahisa Kouwaki, Yukio Fujiwara, Hiroyasu Tsutsuki, Tianli Zhang, Chunyu Guo, Azizur Rahman, Yoshihiro Komohara, Hiroyuki Oshiumi, Tomohiro Sawa   +9 more
wiley   +1 more source

Gasdermin D pores hitch a ride: extracellular vesicles spread pyroptosis. [PDF]

Cell Res
Du G, Wu H.
europepmc   +1 more source