High uric acid exacerbates nonalcoholic steatohepatitis through NLRP3 inflammasome and gasdermin D-mediated pyroptosis. [PDF]
J Biol ChemXu Z +7 more
europepmc +1 more source
The N-terminal domain of gasdermin D induces liver fibrosis by reprogrammed lipid metabolism. [PDF]
Animal Model Exp MedWang X +10 more
europepmc +1 more source
Disulfiram inhibits Gasdermin D pores formation and improves insulin-dependent glucose uptake and glucose homeostasis in skeletal muscle of obesity-induced insulin-resistant mice. [PDF]
Sci RepCadagan C +8 more
europepmc +1 more source
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The recognition of pathogen- or damage- associated molecular patterns (PAMPs/DAMPs) signals a series of coordinated responses as part of innate immunity or host cell defense during infection. The inflammasome is an assemblage of multiprotein complexes in the cytosol that activate inflammatory caspases and release pro-inflammatory mediators. This review
Abosede Salami +2 more
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Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance The inflammasomes are signaling platforms that promote the activation of inflammatory caspases such as caspases-1, -4, -5, and -11, which cleave gasdermin D (GSDMD) to induce pyroptotic cell death. The mechanisms of GSDMD recognition by inflammatory caspases remain poorly understood.
Yinghua Chen +2 more
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Gasdermin D opens the way for NETs
Nature Reviews Rheumatology, 2018Gasdermin D is a pore-forming protein that can cause pyroptosis, a form of inflammatory cell death. New research indicates that the pores generated by gasdermin D can also promote the formation of neutrophil extracellular traps, potentially opening new therapeutic avenues for the treatment of inflammatory diseases.
Lotte Spel, Fabio Martinon
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Gasdermin D and pyroptosis in acute kidney injury
Kidney International, 2019Cell death is a pathophysiological component of acute tubular necrosis and acute kidney injury. Regulated necrosis, however, comes in several different forms. Although necroptosis and ferroptosis have been recently characterized in acute kidney injury, pyroptosis has not been assessed in detail. In this issue of Kidney International, Miao and Yin et al.
Wulf, Tonnus, Andreas, Linkermann
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Versatility of gasdermin D beyond pyroptosis
Trends in Cell BiologyGasdermin D (GSDMD) has garnered significant attention primarily for the pore-forming role of its p30 N-terminal fragment (NT-p30) generated during pyroptosis, a proinflammatory form of cell death. However, emerging evidence suggests that the formation of GSDMD-NT pores is reversible, and the activation of GSDMD does not necessarily lead to pyroptosis.
Tianming Zhao, Zhexu Chi, Di Wang
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Targeting the gasdermin D as a strategy for ischemic stroke therapy
Biochemical Pharmacology, 2021Stroke is a major cause of death and disability worldwide that triggers a variety of neuropathological conditions, leading to the initiation of several pro-inflammatory mediators and neuronal damage. Neuroinflammation has been considered the potential therapeutic target and contributes to the pathology of ischemia and reperfusion.
Jiabing Wang +3 more
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Gasdermin D Cleavage Assay Following Inflammasome Activation
2022Gasdermin D (GSDMD) is a recently identified pore-forming protein that is crucial for the execution of pyroptosis, a highly inflammatory form of cell death. GSDMD contains an N-terminal and a C-terminal domain that are separated by a proteolysis-sensitive linker.
Louisa Janice, Kamajaya, Dave, Boucher
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