Results 61 to 70 of about 20,660 (301)
Biomolecules, 2023 Background: Gasdermin D, a molecule downstream of the nucleotide-binding oligomerization domain-like receptor family pyrin domain containing inflammasome, forms the membrane pore for the secretion of interleukin (IL)-1β and IL-18, and also mediates ...
Jia Guo +8 more
doaj +1 more source
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
Frontiers in Immunology, 2022 Chronic pulmonary inflammation and chronic obstructive pulmonary disease (COPD) are major health issues largely due to air pollution and cigarette smoke (CS) exposure.
Sarah Huot-Marchand +13 more
doaj +1 more source
P2X7 receptor-mediated TG2 externalization: a link to inflammatory arthritis? [PDF]
, 2016 Transglutaminases have important roles in stabilizing extracellular protein assemblies in tissue repair processes but some reaction products can stimulate immune activation, leading to chronic inflammatory conditions or autoimmunity.
Aeschlimann, Daniel, Knauper, Vera
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Apelin-13 promotes expression of pyroptosis related protein in aortic cells in diabetic mice through eNOS/NO pathway [PDF]
Jichu yixue yu linchuang, 2020 Objective To observe the effects and mechanisms of Apelin-13 on expression of pyroptosis related proteins in aorta of diabetic mice. Methods C57/BL mice of eight weeks old were used as control group;kkAy mice of eight weeks old were used as type 2 ...
WANG Yang-jia, ZHANG Jia, LI Bin, ZENG Xiang-jun
doaj
The Role of Gasdermin-D-Mediated Pyroptosis in Organ Injury and Its Therapeutic Implications
Organogenesis, 2023 Gasdermin-D (GSDMD) belongs to the Gasdermin family (GSDM), which are pore-forming effector proteins that facilitate inflammatory cell death, also known as pyroptosis.
Joud Mulla +2 more
doaj +1 more source
Inflammasomes in Host Defense and Autoimmunity [PDF]
, 2016 Inflammasomes are large multi-protein complexes that control host defense and inflammation during infections with pathogens. Their clinical importance however reaches beyond infectious disease, since dysregulated inflammasome activity has also been ...
Broz, Petr
core +2 more sources
Etoposide Treatment of Cancer Cell Lines Results in Nuclear Localisation of Cleaved Gasdermin D
European Journal of BiologyObjective: Overcoming resistance to apoptosis is one of the main goals of cancer treatment. Subversion of apoptosis to pyroptosis, an inflammatory cell death mediated by Gasdermin family members, was previously proposed as an alternative strategy for ...
Soukaina Imlilss +3 more
doaj +1 more source
GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death [PDF]
, 2016 Pyroptosis is a lytic type of cell death that is initiated by inflammatory caspases. These caspases are activated within multi-protein inflammasome complexes that assemble in response to pathogens and endogenous danger signals.
Broz, Petr +9 more
core +1 more source
Advanced Healthcare Materials, EarlyView.Zinc‐containing bioactive glass (ZnBG) promotes diabetic wound healing by regulating macrophage extracellular traps (METs). Specifically, ZnBG reduces oxidative stress and inhibits the PAD4 and NLRP3/caspase‐1/GSDMD signaling pathways, thereby suppressing MET formation.
RuiYang Sun +11 more
wiley +1 more source