Results 91 to 100 of about 15,677 (174)

Retrotransposon-Mediated Fgf5go-Utr Mutant Mice with Long Pelage Hair [PDF]

, 2011
We found 6 spontaneous mutant mice with long pelage hair in our ICR breeding colony. The abnormal trait was restricted to long hair in these mice, which we named moja. They were fertile and showed the same growth and behavior as wild-type mice.
IIJIMA Saori, KAJIWARA Noriko, KUNITA Satoshi, MIZUNO Seiya, OKANO Tomoko, SUGIYAMA Fumihiro, YAGAMI Ken-ichi, 八神 健一, 國田 智, 杉山 文博   +9 more
core   +1 more source

Caspase-1 activates gasdermin A in non-mammals

eLife
Gasdermins oligomerize to form pores in the cell membrane, causing regulated lytic cell death called pyroptosis. Mammals encode five gasdermins that can trigger pyroptosis: GSDMA, B, C, D, and E.
Zachary Paul Billman, Stephen Bela Kovacs, Bo Wei, Kidong Kang, Ousmane H Cissé, Edward A Miao   +5 more
doaj   +1 more source

In vivoresponse of GsdmA3Dfl/+ mice to topically applied fish oil - effects on cellular markers and macrophages [PDF]

, 2016
Psoriasis is an incurable autoimmune disease characterized by patches of abnormal red, itchy and scaly skin. This work examined the modulation of inflammation, hyperproliferation and immune cell markers following topical application of fish oil (FO) in ...
Heard, Charles, Porter, Rebecca, Zulfakar, Mohd Hanif   +2 more
core   +1 more source

MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition [PDF]

, 2019
The nucleotide-binding-domain (NBD)-and leucine-rich repeat (LRR)-containing (NLR) family, pyrin-domain-containing 3 (NLRP3) inflammasome drives pathological inflammation in a suite of autoimmune, metabolic, malignant, and neurodegenerative diseases ...
Demon, Dieter, Fossoul, Amelie, Kayagaki, Nobuhiko, Konvalinka, Jan, Kostka, Libor, Lamkanfi, Mohamed, Lee, Bettina L, Pham, Victoria C, Sacha, Pavel, Simon, Petr, Staben, Steven T, Stivala, Craig E, Stowe, Irma B, Subrt, Vladimir, Van Hauwermeiren, Filip, Vande Walle, Lieselotte, Viana Saavedra, Pedro Henrique, Yamazoe, Sayumi   +17 more
core   +1 more source

Chemical chaperone TUDCA prevents apoptosis and improves survival during polymicrobial sepsis in mice [PDF]

, 2016
Sepsis-induced lymphopenia is a major cause of morbidities in intensive care units and in populations with chronic conditions such as renal failure, diabetes, HIV and alcohol abuse.
Allison, Cody, Doerflinger, Marcel, Glab, Jason, Hotchkiss, Richard S, Jose, Irvin, Lin, Ann, Nedeva, Christina, O’Reilly, Lorraine, Pellegrini, Marc, Puthalakath, Hamsa   +9 more
core   +2 more sources

Genes and Pathways Regulating Decline in Lung Function and Airway Remodeling in Asthma. [PDF]

, 2019
Asthma is a common disorder of the airways characterized by airway inflammation and by decline in lung function and airway remodeling in a subset of asthmatics.
Broide, David H, Hur, Gyu Young
core  

CARD9 negatively regulates NLRP3-induced IL-1β production on Salmonella infection of macrophages. [PDF]

, 2016
Interleukin-1β (IL-1β) is a proinflammatory cytokine required for host control of bacterial infections, and its production must be tightly regulated to prevent excessive inflammation.
Bryant, Clare E, P Monie, Tom, Pereira, Milton, Tourlomousis, Panagiotis, Wright, John   +4 more
core   +2 more sources

Deciphering the complex signalling systems that regulate intestinal epithelial cell death processes and shedding [PDF]

, 2017
Intestinal epithelial cells play a fundamental role in maintaining homeostasis. Shedding of intestinal cells in a controlled manner is critical to maintenance of barrier function.
Agace, Albert, Anon, Arnold, Assi, Barker, Begnaud, Boehm, Brand, Brugués, Capaldo, Chen, Cheung, Du, Dunn, Dürer, Edelblum, Eisenhoffer, Elmore, Ericsson, Farooqui, George, Gilbert, Gu, Guan, Gudipaty, Günther, Günther, Günther, Heller, Hodge, Hughes, Kaemmerer, Kiesslich, Kim, Kocgozlu, Koch, Kofoed, Kuipers, Kumar, Le, Lhocine, Lindemans, Marchiando, Melendez, Nava, Niculescu, Parker, Patnaik, Pentecost, Pentecost, Peterson, Pruteanu, Rankin, Rauch, Ravasio, Sagulenko, Sellin, Smith, Solaymani-Mohammadi, Taylor, Ubelmann, Van Itallie, VanDussen, Wang, Wang, Wang, Watson, Williams, Wong   +69 more
core   +2 more sources

Proinflammatory GSDMD activation in live macrophages and DLBCL cells marks cognate interactions and better prognosis

Blood Advances
: Pyroptosis is a form of programmed cell death characterized by the cleavage of the gasdermin (GSDM) family proteins that form pores in the plasma membrane, cell rupture, and the release of proinflammatory cytokines.
Xue Kong, Zijun Y. Xu-Monette, Zhenming Xu, Eric D. Hsi, Xiaoxian Zhao, Hui Yan, Harry Nunns, Kelly Au, Carlo Visco, Alexandar Tzankov, Karen Dybkaer, Shuna Yao, Dehong Wu, Chang Wang, Alexander M. Xu, Zenggang Pan, Benjamin M. Parsons, April Chiu, Wayne Tam, Santiago Montes-Moreno, Fenghuang Zhan, Leon Bernal-Mizrachi, Youli Zu, Shanxiang Zhang, Michael B. Møller, Weina Chen, Qingyan Au, Akil Merchant, Govind Bhagat, Yong Li, Ken H. Young   +30 more
doaj   +1 more source

Ubiquitin-independent degradation of Bim blocks macrophage pyroptosis in sepsis-related tissue injury

Cell Death and Disease
Pyroptosis, a typical inflammatory cell death mode, has been increasingly demonstrated to have therapeutic value in inflammatory diseases such as sepsis. However, the mechanisms and therapeutic targets of sepsis remain elusive.
Peilin Shi, Yingying Du, Yunyan Zhang, Bo Yang, Qiujing Guan, Yiming Jing, Hao Tang, Jianguo Tang, Chunhui Yang, Xiaoli Ge, Shihui Shen, Lei Li, Chunrong Wu   +12 more
doaj   +1 more source