Results 101 to 110 of about 15,677 (174)

Jefferson Digital Commons quarterly report: April-June 2019 [PDF]

, 2018
This quarterly report includes: Articles CREATE Day Presentations Dissertations From the Archives Grand Rounds and Lectures House Staff Quality Improvement and Patient Safety Posters JCIPE Student Hotspotting Posters Journals and Newsletters MPH ...
Copeland, LIBT, James, Duinkerken, MSI, Kelsey   +1 more
core   +2 more sources

Nucleic acid sensors and programmed cell death [PDF]

, 2020
Liverpool, Layal, Maelfait, Jonathan, Rehwinkel, Jan   +2 more
core   +2 more sources

Engineering a drug-inducible pyroptosis platform enables precise tumor suppression in colorectal cancer

Synthetic and Systems Biotechnology
Colorectal cancer remains a leading cause of cancer-related mortality, with long-term survival rates hindered by chemoresistance and an immunosuppressive tumor microenvironment.
Xiang Yao, Yu Wei, Yuan Gao, Lei Li, Junchi Liu, Wenmin Zhou, Tao Yan, Letian Gong, Yang Zhou, Ganglong Gao   +9 more
doaj   +1 more source

The role of gasdermin-mediated mitochondrial RNA release in amplifying secondary immune response during microbial infection

Frontiers in Immunology
Cytoplasmic RNA serves as a typical damage-associated molecular pattern (DAMP) signal; yet the mechanisms governing its release and role in inflammatory tissue damage remain poorly understood.
Uzair Afaq, Muhammad Suhaib Qudus, Siyu Liu, Kailang Wu, Yu Chen, Mingfu Tian, Jianguo Wu, Jianguo Wu, Jianguo Wu   +8 more
doaj   +1 more source

NLRP3 and beyond: inflammasomes as central cellular hub and emerging therapeutic target in inflammation and disease

Frontiers in Immunology
The NLRP3 inflammasome is a key cytosolic sensor in the innate immune system, activated by diverse danger signals such as metabolic stress, infections, and structural cellular disruptions.
María Virginia Pinzón-Fernández, Jhan S. Saavedra-Torres, Jhan S. Saavedra-Torres, Nelson Adolfo López Garzón, Jessica S. Pachon-Bueno, Francisco Javier Tamayo-Giraldo, María Camila Rojas Gomez, Marlon Arias-Intriago, Alice Gaibor-Pazmiño, Andrés López-Cortés, Juan S. Izquierdo-Condoy   +10 more
doaj   +1 more source

cGAS activation converges with intracellular acidification to promote STING aggregation and pyroptosis in tumor models

The Journal of Clinical Investigation
The cyclic GMP-AMP synthase (cGAS)/stimulator of IFN genes (STING) pathway is intimately associated with antitumoral immunity; however, the direct involvement of this pathway in tumor cell demise remains elusive. Here, we identified a compound, dodecyl 6-
Li Xiao, Yuan-li Ai, Xiang-yu Mi, Han Liang, Xiang Zhi, Liu-zheng Wu, Qi-tao Chen, Tong Gou, Chao Chen, Bo Zhou, Wen-bin Hong, Lu-ming Yao, Jun-jie Chen, Xianming Deng, Fu-nan Li, Qiao Wu, Hang-zi Chen   +16 more
doaj   +1 more source

Effects of surface-exposed sialic acid and LOS outer core on the ability of native Neisseria meningitidis outer membrane vesicles (nOMVs) to induce cytokine expression and pyroptotic pathways in THP-1-derived macrophages

Scientific Reports
Native outer membrane vesicles (nOMVs) are involved in meningococcal pathogenesis and are used for vaccine production. In this study, macrophages derived from the human monocytic cell line THP-1 were exposed to nOMVs from serogroup B N.
Silvia Caterina Resta, Adelfia Talà, Antonio Baccante, Giovanni Saudino, Pasquale Petruccelli, Vito Di Cioccio, Cecilia Bucci, Pietro Alifano   +7 more
doaj   +1 more source

Caspase-4/11 promotes hyperlipidemia and chronic kidney disease–accelerated vascular inflammation by enhancing trained immunity

JCI Insight
To determine whether hyperlipidemia and chronic kidney disease (CKD) have a synergy in accelerating vascular inflammation via trained immunity (TI), we performed aortic pathological analysis and RNA-Seq of high-fat diet–fed (HFD-fed) 5/6 nephrectomy CKD (
Yu Sun, Yifan Lu, Lu Liu, Fatma Saaoud, Ying Shao, Keman Xu, Charles Drummer IV, Ramon Cueto, Huimin Shan, Xiaohua Jiang, Huaqing Zhao, Hong Wang, Xiaofeng Yang   +12 more
doaj   +1 more source

IL2RG knockout mitigates polycystic ovary syndrome pathogenesis by transitioning pyroptosis to apoptosis through the GSDME pathway

Journal of Ovarian Research
Background Polycystic ovary syndrome (PCOS) is a common endocrine disorder with significant impacts on women’s reproductive health. Interleukin (IL)-2 receptor subunit gamma (IL2RG), a common receptor for IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21, has been
Sailing Chen, Han Lu, Yingfen Ying, Haitao Xi, Jingyi Zheng, Chaochao Gong, Shaowei Wang, Yunbin Tang, Junzhao Zhao, Ren-shan Ge, Xiaoheng Li   +10 more
doaj   +1 more source

Antibodies Targeting Gasdermin E as a Potential Therapeutic Option for Psoriasis - A Pilot Study on a Mouse Model. [PDF]

Psoriasis (Auckl)
Nowowiejska-Purpurowicz J, Hermanowicz JM, Pawlak D, Flisiak I, Lipinski T.   +4 more
europepmc   +1 more source