Results 81 to 90 of about 488,720 (294)

GM‐CSF Promotes Neutrophil PD‐L1 Expression Through the VEGFR‐2/STAT6/CSF2 Signaling Axis in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
VEGFR‐2 signaling in OSCC activates Src–STAT6‐dependent CSF2 transcription, driving tumor‐derived GM‐CSF secretion. GM‐CSF programs neutrophils to express PD‐L1 through STAT5–mTOR/S6K signaling, suppressing cytotoxic CD8+ T cells. This pathway reveals a tumor–neutrophil immune checkpoint circuit that limits anti‐PD‐1 responsiveness in OSCC.
Fangxing Zhu, Yuanhe You, Yiyi Zhang, Yibin Dai, Xinyu Zhou, Yong Fu, Xi Lu, Yingying Huang, Zhihang Zhou, Ronghui Xia, Wutong Ju, Zhaoqi Yuan, Laiping Zhong, Tongchao Zhao   +13 more
wiley   +1 more source

Designing dairy desserts for weight management: Structure, physical properties and in vitro gastric digestion [PDF]

, 2017
[EN] The first aim of this study was to observe the effect of adding dairy proteins and reducing the cream content in order to obtain healthier dairy desserts for use in weight management.
Quiles Chuliá, Mª Desamparados, Hernando Hernando, Mª Isabel, Borreani, Jennifer Alexandra Audrey, Llorca Martínez, Mª Empar   +3 more
core   +1 more source

METTL7A Downregulation Drives SLC1A5‐Mediated Glutamine Competition to Promote Tumor Proliferation and Suppress CD8+ T Cell Immunity in Gastric Cancer

Advanced Science, EarlyView.
GC cells enhance glutamine accumulation by upregulating SLC1A5 expression. This upregulation not only boosts GC cell proliferation, but also outcompetes CD8+ T cells for glutamine and suppresses their antitumor immunity. Mechanistically, METTL7A deficiency in GC induces SLC1A5 overexpression via an m6A‐dependent pathway and N‐glycosylation ...
Mingjun Sun, Shuwei Dang, Dazhi Zhou, Lixian Ding, Xun Sun, Wei Suo, Jirui Niu, Qingzhu Yang, Zhicheng Zhang, Yanyan Sun, Jinxing Li, Zhongsheng Chen, Tao Ban, Yingji Wang, Tianzhu Li, Ming Liu, Guodong Li   +16 more
wiley   +1 more source

Digestive Action of Human Gastric Juice.

Experimental Biology and Medicine, 1956
Summary1. The digestive capacity of human gastric juice, adjusted to pH 1.6-1.7, has been measured by perfusion of the cat's esophagus. 2. The gastric secretions of patients with duodenal ulcer, patients in the early postoperative period, and acutely ill patients showed significantly increased necrotizing effects on the esophagus as compared with ...
J F, PERRY, E G, YONEHIRO, P M, YA, H D, ROOT, O H, WANGENSTEEN   +4 more
openaire   +2 more sources

Digestion of Raw and Roasted Almonds in Simulated Gastric Environment [PDF]

, 2009
Knowledge of digestion kinetics of solid foods in human stomach, as affected by food processing methods, is critical in establishing processing conditions at the manufacturing stage to achieve desirable release of nutrients in the gastrointestinal tract.
R. Paul Singh, Kong, Fanbin, Fanbin Kong, Singh, R. Paul   +3 more
core   +1 more source

Lanthanum Carbonate Nanosheets Based Colloidal Hydrogel for Modulating Innate & Adaptive Tumor Immunotherapy by Augmented Cellular Pyroptosis

Advanced Science, EarlyView.
The Gela/decitabine/La2(CO3)3 colloidal (GDLC) hydrogel developed here could reverse the epigenetic silencing of the GSDME gene by the synergistic interaction between DAC and La3+, while concurrently activating caspase‐3, thus facilitating pyroptosis induction under the tumor microenvironment.
Yang Hong, Haitao Wu, Weitao Wang, Xuan Zhang, Qian Chen, Yaoyu Hu, Zhengbao Zha   +6 more
wiley   +1 more source

Investigation into IgG/IgE binding capacity and gut microbiota of digestion products derived from glycated ovalbumin

Food Science and Human Wellness
Gut microbiota plays an important role in food allergy. The immunoglobulin G (IgG)/immunoglobulin E (IgE) binding capacity and human gut microbiota changes of digestion products derived from glycated ovalbumin (OVA) were investigated.
Jihua Mao, Yanhong Shao, Hui Wang, Jun Liu, Zongcai Tu   +4 more
doaj   +1 more source

Antioxidant indices and amino acid composition of phenolic containing Lima beans (Phaseolus lunatus) after simulated human gastrointestinal digestion

International Journal of Food Studies, 2019
The present investigation was designed to characterize the phenolic profile of Lima beans (Phaseolus Lunatus) and also to evaluate the antioxidant indices: total phenolic content (TPC), total flavonoid content (TFC), ferric reducing antioxidant power ...
Sule O. Salawu, Oluwaseun M. Folorunso, Akintunde A. Akindahunsi, Aline A. Boligon   +3 more
doaj   +1 more source

Comparison of clinicopathological features and treatment of gastric adenocarcinoma between Australia and South Korea

, 2012
Many differences in clinicopathological features of gastric cancer and its treatment have been reported between the East and the West however such a comparison using Australian data is still lacking. Gastric cancers seen in Australia differ significantly
Kwon, Sebastianus, Merrett, Neil D. (R14270), Thomson, Iain, Kong, Seong-Ho, Barbour, Andrew, Smithers, Bernard M., Han, Dong-Seok, Yang, Han-Kwang, Chen, Yufei, Chang, David K., Lee, Kyung-Goo, Lee, Hyuk-Joon   +11 more
core  

Supplementary material: Structural changes during gastric digestion in piglets of milk from different species

, 2022
Supplemental figures from manuscript JDS.2021-21388 by Roy et al. entitled "Structural changes during gastric digestion in piglets of milk from different species" published in the Journal of Dairy Science.
Siqi Li (2283472), Natascha Stroebinger (11928554), Carlos A. Montoya (9100454), Aiqian Ye (6790619), Harjinder Singh (634211), Debashree Roy (11928512), Paul J. Moughan (12053063), Suzanne M. Hodgkinson (11866618), Anant C. Dave (12053066)   +8 more
core   +1 more source