Gastric inhibitory polypeptide receptor antagonism suppresses intramuscular adipose tissue accumulation and ameliorates sarcopenia [PDF]
Journal of Cachexia, Sarcopenia and Muscle, 2023 Background Intramuscular adipose tissue (IMAT) formation derived from muscle fibro‐adipogenic progenitors (FAPs) has been recognized as a pathological feature of sarcopenia.
Yuya Takahashi +10 more
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Effects of Mind-Regulation Acupuncture Therapy on Serum Ghrelin, Gastric Inhibitory Polypeptide, Leptin, and Insulin Levels in Breast Cancer Survivors with Cancer-Related Fatigue: A Randomized Controlled Trial [PDF]
International Journal of General Medicine, 2023 Jinxia Li,1 Jingjun Xie,2 Xiaoqing Guo,1 Ruiyang Fu,1 Yaling Wang,1 Xinjun Guan1 1Huzhou Hospital of Traditional Chinese Medicine, Affiliated to Zhejiang Chinese Medical University, Huzhou, Zhejiang, 313000, People’s Republic of China; 2The First People ...
Li J, Xie J, Guo X, Fu R, Wang Y, Guan X
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Association of gastric inhibitory polypeptide receptor (GIPR) gene polymorphism with type 2 diabetes mellitus in iranian patients [PDF]
BMC Medical Genomics, 2023 Introduction Gastric inhibitory polypeptide receptor (GIPR) encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was demonstrated to stimulate insulin secretion. Relation of GIPR gene variation to impaired insulin response
Saiedeh Erfanian +3 more
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Free fatty acid receptors, G protein‐coupled receptor 120 and G protein‐coupled receptor 40, are essential for oil‐induced gastric inhibitory polypeptide secretion [PDF]
Journal of Diabetes Investigation, 2019 Aims/Introduction Incretin hormone glucose‐dependent insulinotropic polypeptide/gastric inhibitory polypeptide (GIP) plays a key role in high‐fat diet‐induced obesity and insulin resistance.
Akiko Sankoda +8 more
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Gastric inhibitory polypeptide (GIP) is selectively decreased in the roux-limb of dietary obese mice after RYGB surgery. [PDF]
PLoS ONE, 2015 Gastric inhibitory polypeptide (GIP, glucose-dependent insulinotropic polypeptide) is expressed by intestinal K cells to regulate glucose-induced insulin secretion. The impact of Roux-en Y bypass (RYGB) surgery on blood GIP is highly contraversial.
Jiaqiang Zhou +4 more
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Gastric inhibitory polypeptide/glucose‐dependent insulinotropic polypeptide signaling in adipose tissue [PDF]
Journal of Diabetes Investigation, 2019 GIPR signaling in adipose tissue plays an important role in HFD‐induced insulin resistance and hepatic steatosis in vivo, with no direct effect on fat accumulation, through IL‐6 ...
Shunsuke Yamane, Norio Harada
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Gastric inhibitory polypeptide receptor methylation in newly diagnosed, drug-naïve patients with type 2 diabetes: a case-control study. [PDF]
PLoS ONE, 2013 GIP action in type 2 diabetic (T2D) patients is altered. We hypothesized that methylation changes could be present in GIP receptor of T2D patients.
Silvia Canivell +9 more
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Investigating the role of melanocortinergic, glutamatergic and neuropeptide Y systems on hypophagia caused by gastric inhibitory polypeptide (GIP) in broilers [PDF]
Poultry Science: Appetite control and the metabolic rate of energy expenditure are under the influence of a broad suite of biochemical messengers, which include peptide-based signals, hormonal agents, and neurotransmitters.
Maryam Lotfi Gharaie +3 more
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Combined treatment with a gastric inhibitory polypeptide receptor antagonist and a peptidyl peptidase-4 inhibitor improves metabolic abnormalities in diabetic mice [PDF]
Journal of International Medical Research, 2021 Objectives Dipeptidyl peptidase-4 inhibition and gastric inhibitory polypeptide (GIP) receptor antagonism have therapeutic effects in type 2 diabetes mellitus. We assessed the effects of sitagliptin and Pro 3 (GIP) in a mouse model of diabetes.
Fei Yang +3 more
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Integrative gene-metabolite network analysis of GLP-1 receptor agonists and related incretin pathways in cardiometabolic health [PDF]
npj Systems Biology and ApplicationsGlucagon-like peptide-1 (GLP-1) is a hormone known for its critical functions in managing blood sugar and offering cardiovascular benefits. Our study focuses on Glucagon Like Peptide 1 Receptor (GLP1R) agonists that act beyond glycemic control in ...
Zofia Wicik +7 more
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