Hormonal predictors of the insulin sensitive phenotype in humans [PDF]
Biomolecules & BiomedicineClinical obesity, a chronic condition marked by excessive fat accumulation, often leads to insulin resistance and a heightened risk of comorbidities. This study aimed to identify hormonal predictors of an insulin-sensitive phenotype (ISP) in patients ...
Mohamed Badie Ahmed +10 more
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Effects of GLP-1 and GIP on cholinergic-induced contractility in isolated jejunal muscle from obese patients with and without type 2 diabetes mellitus [PDF]
Frontiers in PhysiologyBackgroundIntestinal dysmotility in type 2 diabetes mellitus (T2DM) may involve impaired cholinergic and incretin-mediated regulation. This study compared cholinergic-induced jejunal contractility and evaluated the effects of Glucagon like peptide-1 (GLP-
Mantas Malinauskas +7 more
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Gastric inhibitory polypeptide receptor antagonist, SKL-14959, suppressed body weight gain on diet-induced obesity mice. [PDF]
Obes Sci Pract, 2018 Gastric inhibitory polypeptide plays a role in glucose and lipid metabolism and is associated with obesity and insulin resistance. The objective of this study is to confirm the anti‐obesity effects of the gastric inhibitory polypeptide receptor ...
Nakamura T +6 more
europepmc +2 more sources
Mechanisms of fat-induced gastric inhibitory polypeptide/glucose-dependent insulinotropic polypeptide secretion from K cells. [PDF]
J Diabetes Investig, 2016 Gastric inhibitory polypeptide/glucose‐dependent insulinotropic polypeptide (GIP) is one of the incretins, which are gastrointestinal hormones released in response to nutrient ingestion and potentiate glucose‐stimulated insulin secretion.
Yamane S, Harada N, Inagaki N.
europepmc +2 more sources
Discovery of gastric inhibitory polypeptide and its subsequent fate: Personal reflections. [PDF]
J Diabetes Investig, 2016 The present review focuses initially on experimental studies that were designed to identify acid inhibitory factors, referred to as ‘enterogastrones,’ that ultimately led to the isolation of gastric inhibitory polypeptide (GIP), a 42‐amino acid ...
Pederson RA, McIntosh CH.
europepmc +2 more sources
Transcriptional analysis of apoptotic cerebellar granule neurons following rescue by gastric inhibitory polypeptide. [PDF]
Int J Mol Sci, 2014 Apoptosis triggered by exogenous or endogenous stimuli is a crucial phenomenon to determine the fate of neurons, both in physiological and in pathological conditions.
Maino B +3 more
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Sensory and motor physiological functions are impaired in gastric inhibitory polypeptide receptor-deficient mice. [PDF]
J Diabetes Investig, 2014 Gastric inhibitory polypeptide (GIP) is an incretin secreted from the gastrointestinal tract after an ingestion of nutrients, and stimulates an insulin secretion from the pancreatic islets. Additionally, GIP has important roles in extrapancreatic tissues:
Okawa T +11 more
europepmc +2 more sources
Radioimmunoassay of Gastric Inhibitory Polypeptide [PDF]
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 1978 Summary A radioimmunoassay for the measurement of gastric inhibitory polypeptide (GIP) in unextracted plasma in man has been developed using a rabbit antiserum raised against porcine GIP. Porcine GIP was employed also as standard and to produce a 125I-labelled tracer.
L M, Morgan, B A, Morris, V, Marks
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Gastric inhibitory polypeptide receptor (GIPR) is a promising target for imaging and therapy in neuroendocrine tumors. [PDF]
Surgery, 2013 Sherman SK +5 more
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