Results 141 to 150 of about 1,758,994 (174)

Nanostrategies for Therapeutic and Diagnostic Targeting of Gastrin-Releasing Peptide Receptor

International Journal of Molecular Sciences, 2023
Advances in nanomedicine bring the attention of researchers to the molecular targets that can play a major role in the development of novel therapeutic and diagnostic modalities for cancer management.
Agnieszka Piastowska-Ciesielska, Urszula Karczmarczyk, Piotr Ulanski   +2 more
exaly   +2 more sources

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Modified PROMISE criteria for standardized interpretation of gastrin-releasing peptide receptor (GRPR)-targeted PET

European Journal of Nuclear Medicine and Molecular Imaging, 2023
There are image interpretation criteria to standardize reporting prostate-specific membrane antigen (PSMA)-targeted positron emission tomography (PET). As up to 10% of prostate cancer (PC) do not express PSMA, other targets such as gastrin-releasing peptide receptor (GRPR) are evaluated.
Heying Duan, Guido A. Davidzon, Farshad Moradi, Tie Liang, Hong Song, Andrei Iagaru   +5 more
openaire   +2 more sources

Imaging gastrin-releasing peptide receptors (GRPRs) in prostate cancer

Clinical and Translational Imaging, 2018
Despite significant advances in detection and treatment, prostate cancer (PC) remains the most common malignancy and a major cause of cancer death in men worldwide. Imaging is critically important for the diagnosis, staging, and management of men with prostate cancer (PC).
Baratto, Lucia, Laudicella, Riccardo, Picchio, Maria, Baldari, Sergio, Iagaru, Andrei   +4 more
openaire   +1 more source

Immunohistochemical analysis of gastrin-releasing peptide receptor (GRPR) and possible regulation by estrogen receptor βcx in human prostate carcinoma.

Neoplasma, 2012
Gastrin-releasing peptide (GRP) belongs to the family of bombesin-like peptides. GRP was demonstrated to stimulate the proliferation and invasiveness of androgen-independent prostate carcinoma. GRP mediates its action through the membrane-bound receptor, GRP receptor (GRPR), which is characterized by a high-affinity binding for both GRP and bombesin ...

exaly   +4 more sources

Exclusion of the gastrin-releasing peptide receptor (GRPR) locus as a candidate gene for Rett syndrome

American Journal of Medical Genetics, 1998
The gene for the gastrin-releasing peptide receptor (GRPR) has been mapped to a candidate region for Rett syndrome (RTT) on the short arm of the X chromosome. The recent report of a translocation that disrupted the gene in an individual with mental retardation and autistic behavior prompted us to examine GRPR as a possible locus for RTT.
G, Heidary, L L, Hampton, N C, Schanen, M J, Rivkin, B T, Darras, J, Battey, U, Francke   +6 more
openaire   +2 more sources

Gastrin-releasing peptide receptor signaling in the integration of stress and memory

Neurobiology of Learning and Memory, 2014
Neuropeptides act as signaling molecules that regulate a range of aspects of brain function. Gastrin-releasing peptide (GRP) is a 27-amino acid mammalian neuropeptide, homolog of the amphibian peptide bombesin.
Rafael Roesler, Zul Merali, Gilberto Schwartsmann   +2 more
exaly   +2 more sources

Synthesis, preclinical, and initial clinical evaluation of integrin αVβ3 and gastrin-releasing peptide receptor (GRPR) dual-targeting radiotracer [68Ga]Ga-RGD-RM26-03

European Journal of Nuclear Medicine and Molecular Imaging
Integrin receptor αvβ3 and gastrin-releasing peptide receptor (GRPR) expression of tumors could be detected using PET imaging with radiolabeled Arg-Gly-Asp (RGD) and the antagonistic bombesin analog RM26, respectively. The purpose of this study was to investigate the dual receptor-targeting property of the heterodimer RGD-RM26-03 (denoted as LNC1015 ...
Rongxi Wang, Jingjing Zhang, Qingyao Shang   +2 more
exaly   +3 more sources

Monomeric and Dimeric ⁶⁸Ga-Labeled Bombesin Analogues for Positron Emission Tomography (PET) Imaging of Tumors Expressing Gastrin-Releasing Peptide Receptors (GRPrs)

Journal of Medicinal Chemistry, 2018
The GRPr, highly expressed in prostate PCa and breast cancer BCa, is a promising target for the development of new PET radiotracers. The chelator HBED-CC ( N, N'-bis[2-hydroxy-5-(carboxyethyl)benzyl]ethylenediamine- N, N'-diacetic acid) was coupled to the bombesin peptides: HBED-C-BN(2-14) 1, HBED-CC-PEG2-[d-Tyr6,β-Ala11,Thi13,Nle14]-BN(6-14) 2, HBED ...
Christos Liolios, Benjamin Buchmuller, Ulrike Bauder-Wüst, Martin Schäfer, Karin Leotta, Uwe Haberkorn, Matthias Eder, Klaus Kopka   +7 more
openaire   +3 more sources

Single vial cold kits optimized for preparation of gastrin releasing peptide receptor (GRPR)-radioantagonist 68Ga-RM2 using three different 68Ge/68Ga generators

Journal of Pharmaceutical and Biomedical Analysis, 2019
68Ga-RM2 is a gastrin releasing peptide receptor (GRPR) antagonist PET (positron emission tomography) radiotracer which is being investigated in clinical trials as a potential prostate cancer imaging agent. Simple, one-step kit formulation of 68Ga-RM2 would facilitate multicentre trials and allow easier integration in hospital radiopharmacy.
Kusum, Vats, Rohit, Sharma, Mythili, Kameswaran, Drishty, Satpati, Ashutosh, Dash   +4 more
openaire   +2 more sources

Detection rate of gastrin-releasing peptide receptor (GRPr) targeted tracers for positron emission tomography (PET) imaging in primary prostate cancer: a systematic review and meta-analysis

Annals of Nuclear Medicine
The gastrin-releasing peptide receptor (GRPr) has gained recognition as a promising target for both diagnostic and therapeutic applications in a variety of human cancers. This study aims to explore the primary tumor detection capabilities of [68Ga] Ga-GRPr PET imaging, specifically in newly diagnosed intra-prostatic prostate cancer lesions (PCa ...
Atakan Orscelik, Gökçe Belge Bilgin, Brian J Burkett   +2 more
exaly   +3 more sources