Results 151 to 160 of about 1,758,994 (174)

Comparative cell uptake study of FITC-/177Lu-labeled RM26 monomer, dimer and trimer on PC-3: improving binding affinity of gastrin releasing peptide receptor (GRPR) antagonist via bivalency/trivalency

Journal of Radioanalytical and Nuclear Chemistry, 2019
The gastrin releasing peptide receptors (GRPRs) overexpress in various tumors, which provided the opportunity for GRPR targeted tumor radiological diagnosis and therapy. In recent reports, the GPPR antagonists presented superior specific targeting affinity over the agonists.
Liangang Zhuo, Xia Yang, Wei Liao, Jing Wang, Hailin Wang, Minli Lv, Guanquan Wang, Hu Song, Yue Feng, Yue Chen, Hongyuan Wei, Yuchuan Yang, Peng Zhao   +12 more
openaire   +1 more source

Radiochemical investigations of ¹⁷⁷Lu‐DOTA‐8‐Aoc‐BBN[7‐14]NH₂: A new gastrin releasing peptide receptor (GRPr) targeting radiopharma ceutical

Journal of Labelled Compounds and Radiopharmaceuticals, 2001
AbstractThe new conjugate, 177Lu‐DOTA‐8‐Aoc‐BBN[7–14]NH2, was prepared in high yield (≥95%) upon addition of 177LuCl3 to an aqueous solution (Ammonium Acetate) of DOTA‐8‐Aoc‐BBN[7–14]NH2. The 177Lu‐DOTA‐8‐Aoc‐BBN[7–14]NH2‐conjugate is stable over a wide range of pHs and does not undergo in vitro decomposition for ≤24h.
Charles J. Smith, Timothy J. Hoffman, Donald L. Hayes, Nellie K. Owen, Gary L. Sieckman, Wynn A. Volkert   +5 more
openaire   +1 more source

Abstract CT290: Trial in progress: Evaluation of the safety, tolerability, whole-body distribution, radiation dosimetry and antitumor activity of 177Lu-NeoB in patients with advanced solid tumors expressing gastrin-releasing peptide receptor (GRPR)

Cancer Research
Abstract Introduction: Many common cancers such as breast, lung, and prostate, plus several less common malignancies such as gastrointestinal stromal tumors (GIST) and glioblastoma (GBM) express or are associated with the Gastrin-Releasing Peptide Receptor (GRPR).
Erik Mittra, Andrei Iagaru, Astrid Van der Veldt, Luigi Aloj, Jeffrey Wong, Loic Djaileb, Dhrubajyoti Pathak, Yongmin Liu, Lilja Solnes   +8 more
openaire   +1 more source

NeoRay phase IIa results: A study of [ ¹⁷⁷ Lu]Lu-NeoB ( ¹⁷⁷ Lu-NeoB) in pts with advanced solid tumors overexpressing gastrin-releasing peptide receptor (GRPR).

Journal of Clinical Oncology
3095 Background: GRPR is overexpressed in many solid tumors. NeoB binds to GRPR with high affinity and can be radiolabeled for theranostics. NeoRay is the first-in-human study of 177 Lu-NeoB in pts with advanced ...
Erik Mittra, Lilja B. Solnes, Loic Djaileb, Astrid Aplonia Maria Van Der Veldt, Jordi Rodon Ahnert, Jeffrey Y.C. Wong, Andrei Iagaru, Maria Vieito Villar, Ravi Patel, Michael C. Heinrich, Simon Pacey, Steven P. Rowe, Tessa Brabander, Sanjit Tewari, Christopher T. Chen, Ines Lorenzo, Aida Sabate-Llobera, Daniela Baldoni, Yongmin Liu, Luigi Aloj   +19 more
openaire   +1 more source

Gastrin-Releasing Peptide Receptor (GRPR)

2016
Alessia Parascandolo, Maria Domenica Castellone   +1 more
openaire   +1 more source

Molecular basis of the selectivity of the gastrin-releasing peptide receptor (GRPR) for the neurotransmitter, GRP

Gastroenterology, 2001
K TOKITA, S HOCART, D COY, R JENSEN
openaire   +1 more source

Elucidation of receptor domains of gastrin-releasing peptide receptor (GRPR) determining high selectivity for peptide antagonists

Gastroenterology, 1998
T. Katsuno, T.K. Pradhan, S.A. Mantey, P.J. Donohue, J.F. Battey, D.H. Coy, R.T. Jensen   +6 more
openaire   +1 more source

RADIOLABELED COMPOUNDS FOR IN VIVO IMAGING OF GASTRIN-RELEASING PEPTIDE RECEPTOR (GRPR) AND TREATMENT OF GRPR-RELATED DISORDERS

2023
ZHANG CHENGCHENG, LIN KUO-SHYAN, BÉNARD FRANÇOIS, WANG LEI, ZHANG ZHENGXING, BRATANOVIC IVICA   +5 more
openaire   +3 more sources

Different highly selective gastrin-releasing peptide receptor (GRPR) peptide antagonists interact with different receptor domains

Gastroenterology, 2000
Kenji Tokita, Tatsuro Katsuno, Muriel Llinares, Jean Martinez, Robert T. Jensen   +4 more
openaire   +1 more source

Caco-2 cell remodeling is regulated by transient up-regulation of gastrin-releasing peptide (GRP) and its receptor (GRPR)

Gastroenterology, 2003
Sarah Glover, Kristin Keller, Richard V. Benya   +2 more
openaire   +1 more source