Results 41 to 50 of about 65,820 (233)

Effect of Dexmedetomidine-Assisted Intravenous Anesthesia on Gastrointestinal Motility in Colon Cancer Patients After Open Colectomy

Frontiers in Surgery, 2022
BackgroundTo explore the effect of dexmedetomidine (Dex)-assisted intravenous anesthesia on gastrointestinal motility in patients with colon cancer (CC) after open colectomy.MethodsA total of 102 patients with CC, undergoing open colectomy in our ...
Chaopeng Ou, Shiyang Kang, Ruifeng Xue, Jielan Lai, Yingjun Zhang   +4 more
doaj   +1 more source

Therapeutic effects of Bombax ceiba flower aqueous extracts against loperamide-induced constipation in mice

Pharmaceutical Biology, 2023
Context Bombax ceiba Linnaeus (Bombacaceae) is known as silk cotton tree, the flowers of which are used in many medicinal applications.Objective To investigate the therapeutic effect of B.
Liuping Wang, Shiyuan Xie, Xuan Jiang, Caini Xu, Youqiong Wang, Jianfang Feng, Bin Yang   +6 more
doaj   +1 more source

Effect of Intraduodenal Bile and Taurodeoxycholate on Exocrine Pancreatic Secretion and on Plasma Levels of Vasoactive Intestinal Polypeptide and Somatostatin in Man [PDF]

, 1994
Intraduodenal (i.d.) application of bile or Na-taurodeoxycholate (TDC) dose dependently enhances basal exocrine pancreatic secretion. The hydrokinetic effect is mediated at least in part by secretin.
Fiedler, Fritz, Lehnert, Peter, Riepl, Rudolf L., Teufel, Johannes   +3 more
core   +1 more source

Gastrin signaling in cardiovascular pathophysiology: From molecular crosstalk to clinical implications

Clinical and Experimental Hypertension
As a gastrointestinal hormone, gastrin stimulates gastric acid secretion and intestinal mucosal nutrition. Evidence links it closely to coronary heart disease, ischemia‒reperfusion injury and hypertension.
Chunmei Xu, Zhuxin Li, Yongchun Zeng, Hao Luo, Xuewei Xia   +4 more
doaj   +1 more source

Case report: Fundic gland polyps caused by long-term omeprazole use in a Maltese dog

Frontiers in Veterinary Science, 2023
Long-term use of proton-pump inhibitors can induce fundic gland polyps in the human stomach. However, this phenomenon has not been described in the veterinary literature.
Haemin Lee, Sanggu Kim, Dohee Lee, Yeon Chae, Taesik Yun, Mhan-Pyo Yang, Byeong-Teck Kang, Soochong Kim, Hakhyun Kim   +8 more
doaj   +1 more source

Effect of N-Terminal Peptide Modifications on In Vitro and In Vivo Properties of ¹⁷⁷Lu-Labeled Peptide Analogs Targeting CCK2R

Pharmaceutics, 2023
The therapeutic potential of minigastrin (MG) analogs for the treatment of cholecystokinin-2 receptor (CCK2R)-expressing cancers is limited by poor in vivo stability or unfavorable accumulation in non-target tissues. Increased stability against metabolic
Anton Amadeus Hörmann, Maximilian Klingler, Christine Rangger, Christian Mair, Lieke Joosten, Gerben M. Franssen, Peter Laverman, Elisabeth von Guggenberg   +7 more
doaj   +1 more source

Effects of Ostertagia circumcincta larvae and adult parasites on abomasal and intestinal tissues in sheep : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Physiology [PDF]

, 1994
Ostertagia circumcincta parasites infect the abomasum of sheep causing damage to the abomasal tissues and significant production losses to the sheep farming industry.
Hodgkinson, Suzanne Marie
core  

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

bak deletion stimulates gastric epithelial proliferation and enhances Helicobacter felis-induced gastric atrophy and dysplasia in mice [PDF]

, 2015
Helicobacter infection causes a chronic superficial gastritis that in some cases progresses via atrophic gastritis to adenocarcinoma. Proapoptotic bak has been shown to regulate radiation-induced apoptosis in the stomach and colon and also susceptibility
Abuderman, A A, Burkitt, M D, Duckworth, C A, O'Reilly, L A, Pritchard, D M, Williams, J M   +5 more
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source