Results 221 to 230 of about 160,008 (264)

Efficacy and safety of fruquintinib combined with albumin‐bound paclitaxel as second‐line therapy for advanced gastric cancer following failure of PD‐1 inhibitor‐containing treatment (TACTIC GC‐01): A phase II single‐arm study

International Journal of Cancer, EarlyView.
What's New? Anti‐angiogenic drugs have shown promising efficacy as a second‐line treatment for advanced gastric cancer. However, it remains unclear how alterations in the tumor microenvironment following first‐line immunotherapy may impact tumor angiogenesis and influence subsequent therapeutic outcomes. This single‐arm study prospectively explored the
Xiaoting Ma, Kai Ou, Xiu Liu, Biyang Cao, Wenwei Yang, Jingyu Lu, Letian Zhang, Qi Wang, Lizhen Gao, Zhichao Jiang, Yongkun Sun, Lin Yang   +11 more
wiley   +1 more source

Pathophysiological mechanisms of functional dyspepsia: a narrative review. [PDF]

Front Med (Lausanne)
Wang L, Shi Y, Li Y, Wang X, Xu L, Zhang Y.   +5 more
europepmc   +1 more source

Cancer pattern in Bhutan (2014–2022): Findings from population‐based cancer registry—A pathway to monitor cancer control activities

International Journal of Cancer, EarlyView.
What's New? The establishment in 2014 of the population‐based cancer registry (PBCR) of Bhutan created new opportunities for understanding national cancer trends, which previously were anticipated from data in neighbouring countries. This study presents the first nine‐year summary of cancer patterns in Bhutan, derived from PBCR data. From 2014 to 2022,
Phub Tshering, Ugyen Tshomo, Meera Chetri, Sumitra Suberi, Yangdon Yangdon, Laigden Dzed, Tshewang Lhadon, Sonali Bagal, Sharyu Mhamane, Atul Budukh   +9 more
wiley   +1 more source

Immunotherapy in advanced gastroesophageal cancers: A meta‐analysis of sex‐based outcomes in overall survival

International Journal of Cancer, EarlyView.
What's New? Immune checkpoint inhibitors (ICIs) improve survival in advanced gastroesophageal cancer (GEC), but their benefits may differ by sex. Little is known, however about the impact of sex‐related immune differences on ICI efficacy. In this meta‐analysis, sex‐specific outcomes of ICI therapy were evaluated in advanced GEC, encompassing both ...
Michael Masetti, Fausto Petrelli, Filippo Pietrantonio, Sylvie Lorenzen, Alberto Giovanni Leone   +4 more
wiley   +1 more source

Gut sensing of food ingredients and interoception-mediated regulation of feeding and glucose metabolism. [PDF]

Physiol Rep
Iba K, Kitano R, Iwasaki Y.
europepmc   +1 more source

Goitre epidemiology; thyroid volume, iodine excretion, thyroglobulin and thyrotropin in Germany and Sweden [PDF]

, 1985
Friedrich, H. J., Gutekunst, R., Hasenpunsch, U., Scriba, Peter Christian, Smolarek, H., Stubbe, P., Wood, W. G.   +6 more
core  

A multilevel perspective on MSH6‐associated Lynch syndrome: Integrating molecular, biological, and clinical insights

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by a germline pathogenic variant in one of the mismatch repair (MMR) genes. Among these, MSH6‐associated LS represents a distinct subtype with unique molecular and clinical characteristics.
Salwa Ben Yahia, Anne‐Sophie van der Werf‐'t Lam, Madalina Cabuta, Maartje Nielsen, Noah C. Helderman   +4 more
wiley   +1 more source

[Gastrointestinal hormones].

Medizinische Klinik, 1977
  +6 more sources

Host–microbiota interaction drives 5‐hydroxyindole‐3‐acetic acid production to promote linear growth in infant mice

iMetaOmics, EarlyView.
This study discovered that Lactiplantibacillus plantarum Hi188 promoted linear growth in postweaning mice. Transcriptomic analysis, untargeted metabolomics, and in vitro experiments showed that the elevated levels of 5‐hydroxyindole‐3‐acetic acid (5‐HIAA) activated the hepatic aryl hydrocarbon receptor (AhR) and subsequently promoted insulin‐like ...
Yongmei Yang, Jing Yang, Weiyao Zhang, Linghao Zhou, Chenxu Zhu, Xuguang Zhang, Yuejian Mao, Meiling Zhang   +7 more
wiley   +1 more source

Oleoylethanolamide regulates intestinal stem cell activity and villus size via PPARα signaling pathway

iMetaOmics, EarlyView.
First use of a natural swine model with lipid metabolism to directly link lipid differences to a quantifiable intestinal villus height phenotype. Identified the phospholipid‐derived oleoylethanolamide, rather than canonical fatty acids, as the endogenous primary ligand that activates peroxisome proliferator‐activated receptors α (PPARα) to enlarge ...
Qianqian Wang, Lanmei Yin, Zhaobin Wang, Jun Li, Xianglin Zeng, Qiye Wang, Jianzhong Li, Kang Xu, Huansheng Yang, Yulong Yin   +9 more
wiley   +1 more source