Secretin targets interstitial cells of Cajal to regulate intestinal contractions [PDF]
EMBO ReportsSecretin is a gastrointestinal (GI) hormone that slows intestinal motility, an effect thought to be mediated through vagal afferent pathways. In this study we show evidence for a novel function of secretin involving a non-neural mechanism mediated by ...
Allison M Bartlett +3 more
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Structural insights into the secretin complex of a type IVb pilus system [PDF]
Nature CommunicationsThe bundle-forming pilus (BFP) system in enteropathogenic Escherichia coli (EPEC) produces type IVb pili that enable bacterial auto-aggregation, facilitating bacterial adhesion, colonization, and virulence.
Chenchen Pei +8 more
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PilY1 regulates the dynamic architecture of the type IV pilus machine in Pseudomonas aeruginosa [PDF]
Nature CommunicationsType IV pili (T4P) produced by the pathogen Pseudomonas aeruginosa play a pivotal role in adhesion, surface motility, biofilm formation, and infection in humans.
Shuaiqi Guo +5 more
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Origin of secretin receptor precedes the advent of tetrapoda: evidence on the separated origins of secretin and orexin. [PDF]
PLoS ONE, 2011 At present, secretin and its receptor have only been identified in mammals, and the origin of this ligand-receptor pair in early vertebrates is unclear.
Janice K V Tam +7 more
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Molecular Metabolism, 2023 Objective: Obesity is a major global health problem which can be targeted with new mechanistic diverse pharmacological interventions. Here we evaluate a new long-acting secretin receptor agonist as a potential treatment for obesity.
Mona Loeffler +6 more
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A proform of secretin with high secretin‐like bioactivity [PDF]
FEBS Letters, 1985 A variant form of the heptacosapeptide amide secretin, with C‐terminal‐Val‐Gly‐Lys‐Arg instead of valine amide, has been isolated from porcine upper intestinal tissue. Unexpectedly, this triacontapeptide exhibited a substantially higher bioactivity than the heptacosapeptide amide.
Gafvelin, Guro +2 more
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The Potential Role of Gut Peptide Hormones in Autism Spectrum Disorder
Frontiers in Cellular Neuroscience, 2020 Gut peptide hormones are one group of secretory factors produced from gastrointestinal endocrine cells with potent functions in modulating digestive functions.
Xin-Rui Qi, Li Zhang
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MOLECULAR EVOLUTION OF GPCRS: Secretin/secretin receptors [PDF]
Journal of Molecular Endocrinology, 2014 In mammals, secretin is a 27-amino acid peptide that was first studied in 1902 by Bayliss and Starling from the extracts of the jejunal mucosa for its ability to stimulate pancreatic secretion. To date, secretin has only been identified in tetrapods, with the earliest diverged secretin found in frogs.
Chow, BKC, JIN, J, Tam, JKV, Lee, LTO
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Structure-Activity Relationship Studies of N- and C-Terminally Modified Secretin Analogs for the Human Secretin Receptor. [PDF]
PLoS ONE, 2016 The pleiotropic role of human secretin (hSCT) validates its potential use as a therapeutic agent. Nevertheless, the structure of secretin in complex with its receptor is necessary to develop a suitable therapeutic agent. Therefore, in an effort to design
Kailash Singh +8 more
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Pleiotropic Effects of Secretin: A Potential Drug Candidate in the Treatment of Obesity?
Frontiers in Endocrinology, 2021 Secretin is the first hormone that has been discovered, inaugurating the era and the field of endocrinology. Despite the initial focus, the interest in its actions faded away over the decades. However, there is mounting evidence regarding the pleiotropic
Sanna Laurila +6 more
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