Results 41 to 50 of about 15,697 (209)

In situ imaging of bacterial outer membrane projections and associated protein complexes using electron cryo-tomography

eLife, 2021
The ability to produce outer membrane projections in the form of tubular membrane extensions (MEs) and membrane vesicles (MVs) is a widespread phenomenon among diderm bacteria.
Mohammed Kaplan, Georges Chreifi, Lauren Ann Metskas, Janine Liedtke, Cecily R Wood, Catherine M Oikonomou, William J Nicolas, Poorna Subramanian, Lori A Zacharoff, Yuhang Wang, Yi-Wei Chang, Morgan Beeby, Megan J Dobro, Yongtao Zhu, Mark J McBride, Ariane Briegel, Carrie L Shaffer, Grant J Jensen   +17 more
doaj   +1 more source

The mechanism for polar localization of the type IVa pilus machine in Myxococcus xanthus

mBio, 2023
Type IVa pili (T4aP) are important for bacterial motility, adhesion, biofilm formation, and virulence. This versatility is based on their cycles of extension, adhesion, and retraction.
Marco Herfurth, María Pérez-Burgos, Lotte Søgaard-Andersen   +2 more
doaj   +1 more source

Signaling mechanisms of secretin receptor

, 2006
Secretin, a 27-amino acid gastrointestinal peptide, was initially discovered based on its activities in stimulating pancreatic juice. In the past 20 years, secretin was demonstrated to exhibit pleiotropic functions in many different tissues and more ...
Siu, FKY, Lam, IPY, Chu, JYS, Chow, BKC
core   +1 more source

Expression and spatial distribution of secretin and secretin receptor in human cerebellum

, 2005
The expression and spatial distribution of secretin and its receptor in human cerebellum were investigated by in situ hybridization and immunohistochemical techniques.
Chen, L, Chow, BKC, Lee, SMY, Yung, WH
core   +1 more source

Effects of sleep deprivation on sleep and sleep electroencephalogram in secretin-receptor knockout mice

Neuroscience Research
Recent studies has consistently demonstrated a relationship between secretin and autism-like behavior in mice. Therefore, secretin-receptor knockout (SCTR-KO) mice are used to study autism. However, with respect to humans, some studies have reported that
Moridera Aiko, Fujihara Hiroaki, Cherasse Yoan, Mugishima Go, Fujiki Nobuhiro   +4 more
doaj   +1 more source

Structure and dynamics of the active Gs-coupled human secretin receptor

Nature Communications, 2020
The class B secretin GPCR (SecR) has broad physiological effects, with target potential for treatment of metabolic and cardiovascular disease. Here, authors present a cryo-EM structure and biochemical studies of secretin binding to the SecR:Gs complex ...
Maoqing Dong, Giuseppe Deganutti, Sarah J. Piper, Yi-Lynn Liang, Maryam Khoshouei, Matthew J. Belousoff, Kaleeckal G. Harikumar, Christopher A. Reynolds, Alisa Glukhova, Sebastian G. B. Furness, Arthur Christopoulos, Radostin Danev, Denise Wootten, Patrick M. Sexton, Laurence J. Miller   +14 more
doaj   +1 more source

Calcitonin‐like diuretic hormone influences reproduction in adult female Rhodnius prolixus

Insect Science, EarlyView.
Highlights • CT/DH‐like immunoreactivity is present in female reproductive tissues • CT/DH receptor transcripts are expressed in the fat body and ovaries • RNAi knockdown of CT/DH receptors reduces egg number and hatching rate • Rhopr‐CT/DH increases RhoprVg1 and RhoprVgR expression in ovaries in vitro • Rhopr‐CT/DH stimulates oviduct contractions in a
Areej N. Al‐Dailami, Ian Orchard, Angela B. Lange   +2 more
wiley   +1 more source

Novel targets in headache: A narrative review

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background This narrative review summarizes novel applications for the use of calcitonin gene‐related peptide (CGRP)‐targeted therapies that go beyond migraine, the latest updates with respect to targeting pituitary adenylate cyclase‐activating peptide (PACAP) as therapeutic in migraine, as well as exploring other more recently ...
Adriana Della Pietra, Peter J. Goadsby, Carolina Oldoni, Stephen Silberstein, Fred Cohen, Simon Akerman   +5 more
wiley   +1 more source

Cryo-EM structure of the bifunctional secretin complex of Thermus thermophilus

eLife, 2017
Secretins form multimeric channels across the outer membrane of Gram-negative bacteria that mediate the import or export of substrates and/or extrusion of type IV pili.
Edoardo D'Imprima, Ralf Salzer, Ramachandra M Bhaskara, Ricardo Sánchez, Ilona Rose, Lennart Kirchner, Gerhard Hummer, Werner Kühlbrandt, Janet Vonck, Beate Averhoff   +9 more
doaj   +1 more source

Secretin-dependent signals in the ventromedial hypothalamus regulate energy metabolism and bone homeostasis in mice

Nature Communications
Secretin, though originally discovered as a gut-derived hormone, is recently found to be abundantly expressed in the ventromedial hypothalamus, from which the central neural system controls satiety, energy metabolism, and bone homeostasis.
Fengwei Zhang, Wei Qiao, Ji-an Wei, Zhengyi Tao, Congjia Chen, Yefeng Wu, Minghui Lin, Ka Man Carmen Ng, Li Zhang, Kelvin Wai-Kwok Yeung, Billy Kwok Chong Chow   +10 more
doaj   +1 more source