Results 41 to 50 of about 11,202 (179)
The mechanism for polar localization of the type IVa pilus machine in Myxococcus xanthus
mBio, 2023 Type IVa pili (T4aP) are important for bacterial motility, adhesion, biofilm formation, and virulence. This versatility is based on their cycles of extension, adhesion, and retraction.
Marco Herfurth +2 more
doaj +1 more source
Advances in GPCRs Associated With Wnt Signaling Within the Auditory System
Medicine Bulletin, EarlyView.ABSTRACT G protein‐coupled receptors (GPCRs) that interact with the Wnt signaling pathway are pivotal for auditory system homeostasis, as they orchestrate inner ear development, hair cell (HC) regeneration, and hearing preservation. Frizzled (FZD) receptors, the core Wnt‐related GPCRs, bind Wnt ligands and co‐receptors (e.g., LRP5/6) to activate both ...
Liang Wang +3 more
wiley +1 more source
Structure and dynamics of the active Gs-coupled human secretin receptor
Nature Communications, 2020 The class B secretin GPCR (SecR) has broad physiological effects, with target potential for treatment of metabolic and cardiovascular disease. Here, authors present a cryo-EM structure and biochemical studies of secretin binding to the SecR:Gs complex ...
Maoqing Dong +14 more
doaj +1 more source
Movement Disorders Clinical Practice, EarlyView.Abstract Background Non‐motor symptoms, especially autonomic dysfunction, are major contributors to disability and decreased quality of life in Parkinson's disease (PD). Despite being common and having a wide range of clinical facets, exocrine gland dysfunction is still not well recognized and managed.
Renato P. Munhoz +2 more
wiley +1 more source
Pediatric Investigation, EarlyView.This evidence map of 63 studies (n = 6158) showed growth hormone therapy in children with growth hormone deficiency has neutral glucose effects, mixed lipid outcomes, potential benefits for bone mineral density, bone mineral content, and parathyroid hormone, but generally no impact on thyroid function, body composition, or body mass index.
Wei Wu +6 more
wiley +1 more source
Current Cell/Organoid and Animal Models for Primary Sclerosing Cholangitis
Portal Hypertension &Cirrhosis, EarlyView.Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with limited therapeutic options and a marked risk of progression to biliary fibrosis, cirrhosis, and malignancy. Progress in PSC research has been hindered by the lack of models that faithfully recapitulate the complex biliary microenvironment and disease heterogeneity ...
Qigu Yao +4 more
wiley +1 more source
Neuroscience ResearchRecent studies has consistently demonstrated a relationship between secretin and autism-like behavior in mice. Therefore, secretin-receptor knockout (SCTR-KO) mice are used to study autism. However, with respect to humans, some studies have reported that
Moridera Aiko +4 more
doaj +1 more source
Effect of Oral Administration of Intact Casein on Gastrointestinal Hormone Secretion and Pancreatic α-Amylase Activity in Korean Native Steer [PDF]
Asian-Australasian Journal of Animal Sciences, 2013 Three Korean native steers (779±24 kg) fitted with duodenal cannulas were used in a 3×3 Latin square design to investigate the influence of oral administration of soluble proteins, intact casein (IC) and acid hydrolyzed casein (AHC), on gastrointestinal ...
S. B. Lee +9 more
doaj +1 more source
Calcitonin‐like diuretic hormone influences reproduction in adult female Rhodnius prolixus
Insect Science, EarlyView.Highlights • CT/DH‐like immunoreactivity is present in female reproductive tissues • CT/DH receptor transcripts are expressed in the fat body and ovaries • RNAi knockdown of CT/DH receptors reduces egg number and hatching rate • Rhopr‐CT/DH increases RhoprVg1 and RhoprVgR expression in ovaries in vitro • Rhopr‐CT/DH stimulates oviduct contractions in a
Areej N. Al‐Dailami +2 more
wiley +1 more source
Cryo-EM structure of the bifunctional secretin complex of Thermus thermophilus
eLife, 2017 Secretins form multimeric channels across the outer membrane of Gram-negative bacteria that mediate the import or export of substrates and/or extrusion of type IV pili.
Edoardo D'Imprima +9 more
doaj +1 more source